Details of the Drug-Related molecule(s) Interaction Atlas

L-thyroxine Drug Info

DL-Thyroxin; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxin; L-thyroxine; Laevothyroxinum; Laevothyroxinum (acid); Levothyroxin; Levothyroxinum (acid); T4 (Hormone); Tetraiodothyronine; Tetramet; Thyratabs; Thyrax; Thyreoideum; Thyroxinal; Thyroxine (VAN); Thyroxine (l); Thyroxine I 125; Thyroxine iodine; levothyroxine; thyroxin; thyroxine; (-)-Thyroxine; 3,3',5,5'-Tetraiodo-L-thyronine; 3,5,3',5'-Tetraiodo-L-thyronine; 3,5,3',5'-Tetraiodothyronine; 51-48-9; L-T4; t4

Cross-matching ID

PubChem CID

5819

ChEBI ID

CHEMBL1624

CAS Number

CAS 51-48-9

TTD Drug ID

DM83HWL

INTEDE Drug ID

DR1950

General Information of Drug (ID: DM83HWL)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[11]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[14]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[15]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[16]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[17]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[18]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[19]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[6]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[6]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[21]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[22]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[6]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[6]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[6]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[23]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[24]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[30]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[31]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[35]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[26]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[36]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[37]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[39]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[40]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
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Drug(s) Affected By Thyroxine-binding globulin (SERPINA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprolide	DM5XPIJ	Plasma cell myeloma	2A83.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[56]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[59]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[63]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[64]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[56]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[67]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[69]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[75]
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Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
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Drug(s) Affected By Sulfotransferase 4A1 (SULT4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[86]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[8]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[8]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[89]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[90]
Mononitrophenol	DM4QO9G	N. A.	N. A.	Investigative	[8]
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Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[94]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[95]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[94]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[49]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[96]
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Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[101]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[94]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[103]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Substrate	[1]
Thyroxine 5-deiodinase (DIO3)	DET89OV	IOD3_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[3]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[4]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[5]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[5]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[6]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Gene/Protein Processing	[7]
Sulfotransferase 4A1 (SULT4A1)	OT7AL3KJ	ST4A1_HUMAN	Regulation of Drug Effects	[8]
Thyroxine-binding globulin (SERPINA7)	OTUYVTSU	THBG_HUMAN	Protein Interaction/Cellular Processes	[9]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Gene/Protein Processing	[5]
Transthyretin	OTAFXQRA	TTHY_HUMAN	Protein Interaction/Cellular Processes	[10]

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