Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9EQC0)

• Drug Name: Oxidized glutathione Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[1]
Bacterial infection	1A00-1C4Z	Investigative	[2]

• Cross-matching ID:
  PubChem CID: 65359
  ChEBI ID: CHEMBL1372
  CAS Number: CAS 27025-41-8
  TTD Drug ID: DM9EQC0

Molecule-Related Drug Atlas

Drug(s) Targeting Glutathione reductase (GR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[8]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[8]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[8]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[8]
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[8]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[9]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[9]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[9]
1-(2'-chlorophenyl)penta-1,4-dien-3-one	DMKTZSY	Discovery agent	N.A.	Investigative	[10]
Trans-(R(S))-2-Hydroxy-1-phenylethyl nitrate	DMXC98D	Discovery agent	N.A.	Investigative	[11]

Drug(s) Affected By Gamma-crystallin D (CRYGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[13]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[15]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[16]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[19]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[20]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[21]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[22]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[26]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Bortezomib	DMNO38U	Leukemia		Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutathione reductase (GR)	TTEP6RV	GSHR_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Regulation of Drug Effects	[4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[5]
Gamma-crystallin D (CRYGD)	OTW29JC4	CRGD_HUMAN	Post-Translational Modifications	[6]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Regulation of Drug Effects	[7]

References

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