Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDWU1S)

Drug Name
Rubitecan Drug Info
Synonyms
9-Nitrocamptothecin; 91421-42-0; Orathecin; 9-nitro-20(S)-camptothecin; Camptogen; 9-NC; RFS 2000; RFS-2000; UNII-H19C446XXB; Nitrocamptothecin; H19C446XXB; CHEBI:90225; C20H15N3O6; (S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NCGC00167969-01; (s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4h,12h)-dione; 9NC; Q-100889; (4s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione; Inhaled Orathecin; L9NC; Rubitecan (inhaled); Aerosolized liposomal 9 nitro-20 (S) camptothecin; Rubitecan (inhaled), SuperGen; 9-Nitro-20(S)-camptothecin; 9-Nitrocamptothecin (9-NC)
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Phase 3 [1]
Cross-matching ID
PubChem CID
472335
ChEBI ID
CHEBI:90225
CAS Number
CAS 91421-42-0
TTD Drug ID
DMDWU1S
VARIDT Drug ID
DR01438

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase I (TOP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [6]
Topotecan DMP6G8T Central nervous system neoplasm Approved [6]
B-Lactams DMR8YD6 Bacterial infection 1A00-1C4Z Approved [7]
Belotecan hydrocholoride DM3SRJZ Small-cell lung cancer 2C25.Y Approved [8]
Topetecan DMAE6LK Small-cell lung cancer 2C25.Y Approved [9]
Karenitecin DMCRGY4 Lung cancer 2C25.0 Phase 3 [10]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [11]
Exatecan DMCA7FN Solid tumour/cancer 2A00-2F9Z Phase 3 [12]
Edotecarin DM3ZL7D Gastric adenocarcinoma 2B72 Phase 3 [13]
Etirinotecan pegol DMQHX1Y Breast cancer 2C60-2C65 Phase 3 [14]
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Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Folic Acid DMEMBJC Colorectal carcinoma Approved [16]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [17]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [3]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [19]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [20]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [21]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [22]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [3]
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Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [30]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [37]
Paclitaxel DMLB81S Breast carcinoma Approved [38]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [43]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [46]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Verapamil DMA7PEW Angina pectoris BA40 Approved [49]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [59]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [60]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [63]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Fluoxetine DM3PD2C Bipolar depression Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [71]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Gefitinib DM15F0X Colon adenocarcinoma Approved [74]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Etretinate DM2CZFA Keratosis ED56 Approved [76]
Prednisone DM2HG4X Acute asthma CA23 Approved [77]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [64]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [78]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [81]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [37]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [82]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [85]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [86]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [87]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [88]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Prednisone DM2HG4X Acute asthma CA23 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [90]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Fluoxetine DM3PD2C Bipolar depression Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [95]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [50]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Meloxicam DM2AR7L Arthritis FA20 Approved [99]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [100]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [101]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [43]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Verapamil DMA7PEW Angina pectoris BA40 Approved [49]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [102]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [97]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Meloxicam DM2AR7L Arthritis FA20 Approved [104]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [64]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [107]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Gefitinib DM15F0X Colon adenocarcinoma Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [59]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
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Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [111]
Sulfinpyrazone DMEV954 Gout FA25 Approved [112]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [113]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [117]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [118]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [120]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase I (TOP1) TTGTQHC TOP1_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Gene/Protein Processing [4]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [4]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [4]

References

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2 Rubitecan. Expert Opin Investig Drugs. 2006 Jan;15(1):71-9.
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11 Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.
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13 Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36.
14 Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models. Cancer Chemother Pharmacol. 2014 Dec;74(6):1125-37.
15 Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
16 Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50.
17 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
18 The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9.
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21 Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6.
22 Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.
23 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
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25 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
26 Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. Life Sci. 2005 Sep 2;77(16):2059-70. doi: 10.1016/j.lfs.2005.04.021.
27 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
28 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
29 Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. Clin Cancer Res. 2004 May 1;10(9):3179-88. doi: 10.1158/1078-0432.ccr-03-0309.
30 Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249.
31 Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
32 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
33 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
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35 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
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38 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
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40 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
41 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
42 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
43 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
44 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
45 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
46 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
47 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
48 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
49 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
50 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
51 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
52 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
53 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
54 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
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