Details of the Drug-Related molecule(s) Interaction Atlas

Pazopanib Drug Info

Pazopanib; Pazopanib (GW-786034); 444731-52-6; 5-((4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide; 5-(4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide; 5-[[4-[(2,3-dimethylindazol-6-yl)-methyl-amino]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide; 790713-33-6; 7RN5DR86CK; CHEBI:71219; DSSTox_CID_28659; DSSTox_GSID_48733; DSSTox_RID_82929; GW 78603; GW 786034; GW-786034; GW786034; MFCD11616589; NCGC00188865-01; UNII-7RN5DR86CK

Cross-matching ID

PubChem CID

10113978

ChEBI ID

CHEMBL477772

CAS Number

CAS 444731-52-6

TTD Drug ID

DMF57DM

INTEDE Drug ID

DR1248

General Information of Drug (ID: DMF57DM)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[10]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[13]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[15]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[16]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[10]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[17]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[18]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[15]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[24]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[25]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[26]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[13]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[30]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[31]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[33]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[34]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[36]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[39]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[35]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[40]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[41]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[3]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[42]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[42]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[43]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[3]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[42]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[7]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[3]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[44]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[3]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[46]
Methysergide	DM1EF73	Migraine	8A80	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[52]
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Drug(s) Affected By Myeloblastin (PRTN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[60]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[61]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[63]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[68]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[69]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[72]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[63]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[73]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[74]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[66]
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Drug(s) Affected By HLA class I histocompatibility antigen protein P5 (HCP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[78]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[79]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[80]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)^{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[1]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[2]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[1]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[3]
HLA class I histocompatibility antigen protein P5 (HCP5)	OTV0YRI8	HCP5_HUMAN	Drug Response	[4]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[5]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[5]
Myeloblastin (PRTN3)	OT72MHP7	PRTN3_HUMAN	Gene/Protein Processing	[6]
Phosphatidylcholine translocator ABCB4 (ABCB4)	OTE6PY83	MDR3_HUMAN	Gene/Protein Processing	[7]
UDP-glucuronosyltransferase 1A1	OTH1C8OJ	UD11_HUMAN	Drug Response	[8]

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