Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFX6G8)

Drug Name
Nelfinavir mesylate Drug Info
Synonyms
Nelfin; Nelfinavir (Mesylate); Nelfinavir Mesylate [USAN]; Nelfinavir Methanesulfonate; Nelfinavir mesilate; Nelfinavir mesylate; Nelfinavir mesylate hydrate; Nelfinavir; NELFINAVIR MESYLATE AG1343; Nelfinavir [INN:BAN]; (3S-(2(2S*,3S*),3alpha,4abeta,8abeta))-N-(1,1-Dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-3-isoquinolinecarboxamide; 159989-64-7; 1UN; 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE; C32H45N3O4S; CHEBI:7496; HO3OGH5D7I; NLF; UNII-HO3OGH5D7I; 98D603VP8V; C32H45N3O4S.CH4O3S; CHEBI:7497; CHEMBL1205; DSSTox_CID_10777; DSSTox_GSID_33736; DSSTox_RID_79093; HSDB 7159; MFCD00931436; Nelfinavir methanesulfonate hydrate; UNII-98D603VP8V
Cross-matching ID
PubChem CID
64142
ChEBI ID
CHEMBL7497
CAS Number
CAS 159989-65-8
TTD Drug ID
DMFX6G8
INTEDE Drug ID
DR1138

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [11]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [12]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [13]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [14]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [15]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [16]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [17]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [18]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [12]
Verapamil DMA7PEW Angina pectoris BA40 Approved [1]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [22]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [29]
Verapamil DMA7PEW Angina pectoris BA40 Approved [30]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [22]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [22]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [22]
Metronidazole DMTIVEN Abscess Approved [31]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [32]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [29]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [39]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [40]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [6]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [41]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [41]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [42]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [6]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [41]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [43]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [44]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [6]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [46]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [47]
Diazepam DM08E9O Alcohol withdrawal Approved [48]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [49]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [50]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [51]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [61]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [61]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [61]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [7]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [65]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [66]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [70]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [73]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [75]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [76]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [77]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [75]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [83]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [77]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [85]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [95]
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Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [102]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [103]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [70]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [71]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [107]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
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Drug(s) Affected By Inhibin beta E chain (INHBE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [111]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [112]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [111]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Fluoxetine DM3PD2C Bipolar depression Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [113]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [114]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [111]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
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Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
Cerulenin DM6N4PR Weight loss MG43.5 Approved [120]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [77]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [130]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [131]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [85]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [132]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [132]
Gefitinib DM15F0X Colon adenocarcinoma Approved [133]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [46]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [134]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [135]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [137]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [138]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [139]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [140]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [141]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [142]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [143]
Cepharanthine DM9Y5JB N. A. N. A. Approved [144]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [145]
Clozapine DMFC71L Schizophrenia 6A20 Approved [146]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [147]
Trifluoperazine DMKBYWI Anxiety Approved [148]
Olanzapine DMPFN6Y Bipolar depression Approved [146]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [1]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [2]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [3]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Drug Response [5]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [6]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [5]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [7]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Gene/Protein Processing [7]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Gene/Protein Processing [8]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Protein Interaction/Cellular Processes [9]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [8]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Post-Translational Modifications [10]

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15 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
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22 Drug Interactions Flockhart Table
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