Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFX6G8)

• Drug Name: Nelfinavir mesylate Drug Info
• Synonyms: Nelfin; Nelfinavir (Mesylate); Nelfinavir Mesylate [USAN]; Nelfinavir Methanesulfonate; Nelfinavir mesilate; Nelfinavir mesylate; Nelfinavir mesylate hydrate; Nelfinavir; NELFINAVIR MESYLATE AG1343; Nelfinavir [INN:BAN]; (3S-(2(2S*,3S*),3alpha,4abeta,8abeta))-N-(1,1-Dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-3-isoquinolinecarboxamide; 159989-64-7; 1UN; 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE; C32H45N3O4S; CHEBI:7496; HO3OGH5D7I; NLF; UNII-HO3OGH5D7I; 98D603VP8V; C32H45N3O4S.CH4O3S; CHEBI:7497; CHEMBL1205; DSSTox_CID_10777; DSSTox_GSID_33736; DSSTox_RID_79093; HSDB 7159; MFCD00931436; Nelfinavir methanesulfonate hydrate; UNII-98D603VP8V
• Cross-matching ID:
  PubChem CID: 64142
  ChEBI ID: CHEBI:7497
  CAS Number: CAS 159989-65-8
  TTD Drug ID: DMFX6G8
  INTEDE Drug ID: DR1138

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[10]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[13]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[15]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[16]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[10]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[1]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[42]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[43]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[44]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[45]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[46]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[47]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[22]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[24]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[25]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[20]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[48]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[49]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[50]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[54]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[26]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[28]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[20]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[20]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[20]
Metronidazole	DMTIVEN	Abscess		Approved	[29]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[37]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[38]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[56]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[57]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[64]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[65]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[7]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[66]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[66]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[67]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[66]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[68]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[7]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[69]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[7]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[70]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[71]
Fructose	DM43AN2	Vomiting	MD90	Approved	[72]
Ketoprofen	DMRKXPT	Bursitis		Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[74]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[75]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[76]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[81]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[82]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[84]
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[86]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[87]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[72]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[89]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[90]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[91]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[92]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[93]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[98]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[100]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[4]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[84]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[106]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[107]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[107]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[107]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[111]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[117]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Selenium	DM25CGV	N. A.	N. A.	Approved	[120]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[92]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[121]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[122]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[125]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[4]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[128]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[129]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[140]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[135]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[145]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[146]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[147]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[145]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[152]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[147]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[154]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[120]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[171]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[179]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[142]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[72]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[4]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[4]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[4]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[193]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[196]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[197]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[198]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[199]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[200]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[202]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[203]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[204]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[186]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[209]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[212]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[213]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[214]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[215]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[216]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[217]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[218]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[217]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[217]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[219]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[217]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[74]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[182]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[224]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[225]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[226]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[227]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[228]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[231]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[232]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[4]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[4]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[233]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[234]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[4]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[4]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[237]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[243]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[147]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[250]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[154]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[251]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[251]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[252]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[72]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[253]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[254]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[257]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[258]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[259]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[260]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[261]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[262]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[263]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[264]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[265]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[266]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[267]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[265]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[268]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[272]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[273]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[274]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[275]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[276]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[276]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[277]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[278]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[279]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[282]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[274]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[2]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[3]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Gene/Protein Processing	[4]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[5]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Regulation of Drug Effects	[6]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Drug Response	[6]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[7]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[4]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Gene/Protein Processing	[4]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[8]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Gene/Protein Processing	[8]

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