Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG6Q45)

Drug Name
TDZD-8 Drug Info
Synonyms
327036-89-5; 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; GSK-3beta Inhibitor I; TDZD 8; 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-; MFCD04973552; NP 01139; AK-48153; 4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione; 1,2,4-Thiadiazolidine-3,5-dione,2-methyl-4-(phenylmethyl)-; GSK-3 Inhibitor I; SCHEMBL139834; GTPL5977; CHEMBL284861; BDBM7781; CTK4G9152; ZINC27361; AOB6176; EX-A109; DTXSID30399590; JDSJDASOXWCHPN-UHFFFAOYSA-N; MolPort-003-844-896; HMS3229G12; A Inhibitor I, TDZD-8
Indication
Disease Entry ICD 11 Status REF
Malignant glioma 2A00.0 Patented [1]
Cross-matching ID
PubChem CID
4124851
ChEBI ID
CHEMBL284861
CAS Number
CAS 327036-89-5
TTD Drug ID
DMG6Q45

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AMO-02 DMJRU3A Myotonic dystrophy 8C71.0 Phase 2/3 [5]
LY2090314 DMTBFE4 Acute myeloid leukaemia 2A60 Phase 2 [1]
Lithium DMZ3OU6 Bipolar disorder 6A60 Phase 2 [6]
Tideglusib DME4LA1 Alzheimer disease 8A20 Phase 2 [7]
9-ING-41 DM57TY3 Myelofibrosis 2A20.2 Phase 2 [8]
Neu-120 DMXKOUC Parkinson disease 8A00.0 Phase 1/2 [9]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [10]
CHIR-99021 DMB8MNU Allergic inflammation 4A80-4A85 Patented [11]
AR-A014418 DMUPN01 Ovarian cancer 2C73 Patented [12]
PMID26161698-Compound-18 DM6JVR5 N. A. N. A. Patented [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Glycogen synthase kinase-3 alpha (GSK-3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
LY2090314 DMTBFE4 Acute myeloid leukaemia 2A60 Phase 2 [1]
Lithium DMZ3OU6 Bipolar disorder 6A60 Phase 2 [6]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [1]
CHIR-99021 DMB8MNU Allergic inflammation 4A80-4A85 Patented [1]
AR-A014418 DMUPN01 Ovarian cancer 2C73 Patented [1]
PMID27828716-Compound-21 DMO1NAR N. A. N. A. Patented [1]
Thiadiazolidindione derivative 2 DM5AUL0 N. A. N. A. Patented [1]
PMID27828716-Compound-18 DMNR6KL N. A. N. A. Patented [1]
PMID27828716-Compound-BIO-acetoxime DMUM5L6 Malignant glioma 2A00.0 Patented [1]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [18]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [20]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [21]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [16]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [26]
Paclitaxel DMLB81S Breast carcinoma Approved [27]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [18]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [39]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Gefitinib DM15F0X Colon adenocarcinoma Approved [44]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Etretinate DM2CZFA Keratosis ED56 Approved [47]
Prednisone DM2HG4X Acute asthma CA23 Approved [48]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [49]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [50]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [57]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [58]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [55]
Ethacrynic acid DM60QMR Edema MG29 Approved [59]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Sorbitol DMAN0DE Constipation DD91.1 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division control protein 6 homolog (CDC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycogen synthase kinase-3 alpha (GSK-3A) TTRZQE3 GSK3A_HUMAN Inhibitor [1]
Glycogen synthase kinase-3 beta (GSK-3B) TTRSMW9 GSK3B_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Post-Translational Modifications [4]

References

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9 Company report (Neurim Pharmaceuticals)
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50 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
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59 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
60 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
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67 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
68 Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. J Cell Biochem. 2010 Dec 15;111(6):1546-55. doi: 10.1002/jcb.22886.