Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGBT68)

• Drug Name: Chlorphrifos oxon Drug Info
• Synonyms: Diethyl 3,5,6-trichloropyridin-2-yl phosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 21804
  ChEBI ID: CHEMBL444970
  CAS Number: CAS 5598-15-2
  TTD Drug ID: DMGBT68

Molecule-Related Drug Atlas

Drug(s) Targeting Fatty acid amide hydrolase (FAAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[10]
Thiopental	DMGP8AX	Anaesthesia	9A78.6	Approved	[11]
JNJ-42165279	DM72GZO	Anxiety disorder	6B00-6B0Z	Phase 2	[12]
SSR411298	DMGTB2Q	Major depressive disorder	6A70.3	Phase 2	[13]
IW-6118	DMP42W1	Inflammation	1A00-CA43.1	Phase 2	[14]
PF-04457845	DMPRYU1	Liver disease	DB90-BD99	Phase 2	[15]
IPI-940	DMEIM5G	Pain	MG30-MG3Z	Phase 1	[16]
PMID29053063-Compound-11d	DMDRK68	N. A.	N. A.	Patented	[17]
Piperazine carbamic compound 1	DMZSYU4	N. A.	N. A.	Patented	[17]
Piperazine carbamic compound 2	DMMQ0ZO	N. A.	N. A.	Patented	[17]

Drug(s) Targeting Acetylcholinesterase (AChE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[18]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[19]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[20]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[21]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[22]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[23]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[24]
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[25]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[26]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[27]

Drug(s) Targeting Cannabinoid receptor 1 (CB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[29]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[30]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[31]
Tebipenem	DMVSX6O	Urinary tract infection	GC08	Phase 3	[32]
Conatumumab	DM2UOSN	Colorectal cancer	2B91.Z	Phase 2	[33]
GW-42004	DMY3KSU	Lipid metabolism disorder	5C52.Z	Phase 2	[34]
SR-147778	DMNAECP	Obesity	5B81	Phase 2	[35]
Nimacimab	DM21Z68	Diabetic nephropathy	GB61.Z	Phase 2	[36]
AEF0117	DMQ1GH4	Marijuana use disorder	6C41	Phase 2	[37]

Drug(s) Affected By Fatty-acid amide hydrolase 1 (FAAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[44]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[45]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[46]
ASP-8477	DMBZQS7	Neuropathic pain	8E43.0	Phase 2	[47]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[54]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[62]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[63]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[64]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]

Drug(s) Affected By Serotransferrin (TF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[72]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[74]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[75]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[76]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[77]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[78]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[79]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[81]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[82]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[83]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[81]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[84]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[90]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[91]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[101]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[102]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[103]

Drug(s) Affected By Neutral cholesterol ester hydrolase 1 (NCEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[110]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[110]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[53]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[42]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[119]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[120]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[120]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[121]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[58]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[122]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[126]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[127]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 8 (CHD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[128]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[131]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[132]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[131]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[133]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[134]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[58]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[135]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[136]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[137]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[138]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[139]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[2]
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Inhibitor	[1]
Fatty acid amide hydrolase (FAAH)	TTDP1UC	NOUNIPROTAC	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Gene/Protein Processing	[3]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Drug Response	[4]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[5]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[3]
Chromodomain-helicase-DNA-binding protein 8 (CHD8)	OTS7A6AF	CHD8_HUMAN	Drug Response	[6]
DNA replication licensing factor MCM2 (MCM2)	OTGGORIQ	MCM2_HUMAN	Gene/Protein Processing	[7]
Fatty-acid amide hydrolase 1 (FAAH)	OT9DX3N1	FAAH1_HUMAN	Gene/Protein Processing	[3]
Glutamate decarboxylase 1 (GAD1)	OT52Z39J	DCE1_HUMAN	Protein Interaction/Cellular Processes	[8]
Neutral cholesterol ester hydrolase 1 (NCEH1)	OTZ66CKX	NCEH1_HUMAN	Gene/Protein Processing	[7]
Patatin-like phospholipase domain-containing protein 6 (PNPLA6)	OTT5T45Q	PLPL6_HUMAN	Gene/Protein Processing	[9]

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