Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGTSCP)

Drug Name
JWH-015 Drug Info
Synonyms
JWH-015; 155471-08-2; JWH 015; UNII-W4FL204T10; (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone; JWH015; (2-methyl-1-propylindol-3-yl)-naphthalen-1-ylmethanone; CHEMBL306764; W4FL204T10; MFCD02094630; (2-methyl-1-propyl-1H-indol-3-yl)(naphthalen-1-yl)methanone; JHW 015; SR-01000597570; (2-Methyl-1-propylindol-3-yl)(naphthalen-1-yl)methanone; NCGC00025117-01; Tocris-1341; PubChem19328; MLS002153392; SCHEMBL497044; GTPL5558; AC1N784D; BDBM21282; CHEBI:92318; DTXSID60165902; AOB5643; MolPort-003-983-602
Indication
Disease Entry ICD 11 Status REF
Organ transplant rejection NE84 Patented [1]
Cross-matching ID
PubChem CID
4273754
ChEBI ID
CHEBI:92318
CAS Number
CAS 155471-08-2
TTD Drug ID
DMGTSCP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cannabinoid receptor 2 (CB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [2]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [8]
GW-42004 DMY3KSU Lipid metabolism disorder 5C52.Z Phase 2 [9]
KHK-6188 DMF6CTI Neuropathic pain 8E43.0 Phase 2 [10]
LY-2828360 DMO8IEZ Pain MG30-MG3Z Phase 2 [10]
APD371 DM3XT5V Crohn disease DD70 Phase 2 [11]
S-777469 DMZGNOJ Atopic dermatitis EA80 Phase 2 [12]
842166X DMOV0AP Pain MG30-MG3Z Phase 2 [13]
Beta-caryophyllene DM7583A Pain MG30-MG3Z Phase 2 [14]
Vicasinabin DMF16CU Diabetic retinopathy 9B71.0 Phase 2 [15]
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Drug(s) Affected By Cannabinoid receptor 2 (CNR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [16]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [20]
Menthol DMG2KW7 Back pain ME84.Z Approved [21]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [22]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [23]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [24]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [25]
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Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [28]
Fructose DM43AN2 Vomiting MD90 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [33]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [34]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [35]
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Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [5]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ethanol DMDRQZU Chronic pain MG30 Approved [5]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [42]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [48]
Prednisone DM2HG4X Acute asthma CA23 Approved [49]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [52]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [48]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [53]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [54]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [55]
Prednisone DM2HG4X Acute asthma CA23 Approved [56]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [58]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [59]
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Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [62]
Selenium DM25CGV N. A. N. A. Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [65]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [5]
Testosterone DM7HUNW Hot flushes GA30 Approved [66]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [31]
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Drug(s) Affected By Interleukin-11 (IL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Leflunomide DMR8ONJ Arthritis FA20 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ethanol DMDRQZU Chronic pain MG30 Approved [75]
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Drug(s) Affected By Cannabinoid receptor 1 (CNR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Menthol DMG2KW7 Back pain ME84.Z Approved [21]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [80]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [81]
Norepinephrine DMOUC09 Alopecia ED70 Approved [82]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [83]
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Drug(s) Affected By Mu-type opioid receptor (OPRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alvimopan DMHR8KW Gastrointestinal disease DE2Z Approved [84]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [85]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [89]
Oliceridine DM6MDCF Acute pain MG31 Approved [85]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [23]
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Drug(s) Affected By Eotaxin (CCL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prednisone DM2HG4X Acute asthma CA23 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [91]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [92]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Ethanol DMDRQZU Chronic pain MG30 Approved [5]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [93]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [94]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [95]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [96]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cannabinoid receptor 2 (CB2) TTMSFAW CNR2_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Gene/Protein Processing [3]
Cannabinoid receptor 2 (CNR2) OTYP9P43 CNR2_HUMAN Protein Interaction/Cellular Processes [4]
Eotaxin (CCL11) OT3BIFPK CCL11_HUMAN Gene/Protein Processing [5]
Interleukin-11 (IL11) OTXHN86R IL11_HUMAN Gene/Protein Processing [5]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Gene/Protein Processing [3]
Macrophage colony-stimulating factor 1 (CSF1) OT68M7RD CSF1_HUMAN Gene/Protein Processing [5]
Mu-type opioid receptor (OPRM1) OT16AAT8 OPRM_HUMAN Gene/Protein Processing [6]
Platelet-derived growth factor subunit B (PDGFB) OTMFMFC3 PDGFB_HUMAN Gene/Protein Processing [5]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Gene/Protein Processing [7]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Gene/Protein Processing [5]

References

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73 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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