Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMHU8G)

Drug Name
chlordane Drug Info
Synonyms Chlorindan; chlordan
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5993
ChEBI ID
CHEBI:34623
CAS Number
CAS 57-74-9
TTD Drug ID
DMMHU8G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen-related receptor-alpha (ESRRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rimexolone DMTAREC Arthritis FA20 Approved [8]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [9]
D-5519 DM9FAJM Asthma CA23 Phase 3 [10]
Dexamethasone palmitate DMCMT4V Choroidal neovascularization 9B76 Phase 1/2 [11]
RPR-106541 DMRGC5B Asthma CA23 Discontinued in Phase 2 [12]
Rofleponide DM6OSPQ Allergic rhinitis CA08.0 Discontinued in Phase 2 [13]
AD-121 DMB8XJM Rheumatoid arthritis FA20 Discontinued in Phase 1/2 [8]
GW-250495 DMWJZAP Asthma CA23 Discontinued in Phase 1 [8]
PLD-177 DMPHUBO Allergic rhinitis CA08.0 Terminated [8]
Steroid hormone conjugates DMOJM08 Cachexia MG20 Terminated [14]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [18]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [19]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [19]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [20]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [21]
Capsaicin DMGMF6V Back pain ME84.Z Approved [22]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [23]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [24]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [25]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [26]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [27]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [28]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [29]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [30]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [31]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [32]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [33]
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Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [34]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [35]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [34]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Dolutegravir DMCZGRE Human immunodeficiency virus infection 1C62 Approved [39]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [34]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [40]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [41]
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Drug(s) Affected By Retinoic acid receptor beta (RARB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [48]
Folic Acid DMEMBJC Colorectal carcinoma Approved [49]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [50]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [42]
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Drug(s) Affected By Retinoic acid receptor gamma (RARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [51]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [52]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [53]
Ethanol DMDRQZU Chronic pain MG30 Approved [48]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [54]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [56]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [59]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [60]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [65]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Fluoxetine DM3PD2C Bipolar depression Approved [62]
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Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [68]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [69]
Trospium chloride DM32XZT Discovery agent N.A. Approved [70]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [71]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [72]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [76]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [73]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [79]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [80]
Cepharanthine DM9Y5JB N. A. N. A. Approved [81]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [82]
Clozapine DMFC71L Schizophrenia 6A20 Approved [83]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [84]
Trifluoperazine DMKBYWI Anxiety Approved [85]
Olanzapine DMPFN6Y Bipolar depression Approved [83]
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Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [86]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [89]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [90]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
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Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [93]
Sulfinpyrazone DMEV954 Gout FA25 Approved [94]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [95]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [91]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [99]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [102]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [102]
Gefitinib DM15F0X Colon adenocarcinoma Approved [103]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [104]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [105]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [106]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [109]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [110]
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Drug(s) Affected By Retrotransposon-like protein 1 (RTL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [111]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [112]
UNC0379 DMD1E4J Hepatocellular carcinoma 2C12.02 Preclinical [113]
Drug(s) Affected By Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [118]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [116]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [119]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [120]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [120]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [121]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [123]
Etidronic acid DM1XHYJ Bone Paget disease Approved [120]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [120]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [120]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [124]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [125]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [126]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [130]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [132]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [129]
Estrone DM5T6US Acne vulgaris ED80 Approved [134]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [135]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [136]
Gefitinib DM15F0X Colon adenocarcinoma Approved [137]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [138]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [139]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [140]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [142]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Artemether DM48QOT Malaria 1F40-1F45 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [89]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [149]
Estrone DM5T6US Acne vulgaris ED80 Approved [150]
Leflunomide DMR8ONJ Arthritis FA20 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
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Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Gefitinib DM15F0X Colon adenocarcinoma Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [153]
Estrone DM5T6US Acne vulgaris ED80 Approved [154]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [155]
Testosterone DM7HUNW Hot flushes GA30 Approved [156]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [157]
Mestranol DMG3F94 Contraception QA21 Approved [158]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [159]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen-related receptor-alpha (ESRRA) TTPNQAC ERR1_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [3]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Gene/Protein Processing [4]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [4]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [4]
Cytochrome P450 26A1 (CYP26A1) OTL1DFWV CP26A_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [6]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [6]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [7]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Gene/Protein Processing [7]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Gene/Protein Processing [4]

References

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3 Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108.
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6 A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem Pharmacol. 2004 Dec 15;68(12):2347-58.
7 Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect. 2004 Apr;112(5):524-31. doi: 10.1289/ehp.6649.
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9 Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6.
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15 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
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19 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
20 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
21 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
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23 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
24 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
25 Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
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33 Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36.
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35 Beta-Carotene conversion into vitamin A in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3562-9.
36 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
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38 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
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40 Estrogen receptor alpha (ER)-mediated coregulator binding and gene expression discriminates the toxic ER agonist diethylstilbestrol (DES) from the endogenous ER agonist 17-estradiol (E2). Cell Biol Toxicol. 2020 Oct;36(5):417-435. doi: 10.1007/s10565-020-09516-6. Epub 2020 Feb 22.
41 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
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