Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNI3U2)

Drug Name
ZIMELIDINE Drug Info
Synonyms
Prestwick0_000092; Prestwick1_000092; 56775-88-3; AC1L26VA; NCIStruc1_001846; NCIStruc2_001359; SPBio_001983; 2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-; CTK1F3832; OYPPVKRFBIWMSX-UHFFFAOYSA-N; DB04832; NCI60_002580; FT-0675907; N,N-dimethyl-3-(4-bromophenyl)-3-(pyrid-3-yl)allylamine; N,N-dimethyl-3-(4-bromophenyl)-3-(3-pyridyl)-allylamine; (Z)-3-[1-(p-Bromophenyl)-3-(dimethylamino)propenyl]pyridine; 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-3-ylprop-2-en-1-amine
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Withdrawn from market [1]
Major depressive disorder 6A70.3 Withdrawn from market [2]
Cross-matching ID
PubChem CID
5365247
ChEBI ID
CHEMBL92824
CAS Number
CAS 56775-88-3
TTD Drug ID
DMNI3U2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Serotonin transporter (SERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [7]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [9]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [10]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [11]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [12]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [13]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [9]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [9]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [9]
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Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [4]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [5]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [15]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [5]
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Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [15]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [4]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [19]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [20]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [4]
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Drug(s) Affected By Inhibin beta E chain (INHBE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [4]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [15]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [21]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [5]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [22]
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Drug(s) Affected By Acid ceramidase (ASAH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [4]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [23]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [5]
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Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [4]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [4]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [5]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [4]
Haloperidol DM96SE0 Delirium Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Clozapine DMFC71L Schizophrenia 6A20 Approved [4]
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Drug(s) Affected By Protein DEPP1 (DEPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [4]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [5]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [28]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [5]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [5]
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Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [5]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [33]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [15]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [34]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [37]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [5]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
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Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [4]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [15]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [5]
Fluoxetine DM3PD2C Bipolar depression Approved [5]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [4]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [39]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [40]
Haloperidol DM96SE0 Delirium Approved [5]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [42]
Methysergide DM1EF73 Migraine 8A80 Approved [6]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [46]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Gene/Protein Processing [4]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Gene/Protein Processing [4]
AP-1 complex subunit sigma-1A (AP1S1) OTQ2H8DN AP1S1_HUMAN Gene/Protein Processing [5]
Fibronectin type III domain-containing protein 4 (FNDC4) OTOQK0WK FNDC4_HUMAN Gene/Protein Processing [4]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Gene/Protein Processing [4]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Gene/Protein Processing [5]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Gene/Protein Processing [4]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Gene/Protein Processing [5]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [6]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Gene/Protein Processing [4]

References

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