Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTW3R8)

Drug Name
Sulfadiazine Drug Info
Synonyms
Adiazin; Adiazine; CocoDiazine; Codiazine; Cremodiazine; Cremotres; Debenal; Deltazina; Diazin; Diazolone; Diazovit; Diazyl; Eskadiazine; Liquadiazine; Microsulfon; Neazine; Neotrizine; Palatrize; Piridisir; Pirimal; Pyrimal; Quadetts; Quadramoid; Sanodiazine; Solfadiazina; Spofadrizine; Sterazine; Sulfadiazene; Sulfadiazin; Sulfadiazina; Sulfadiazinum; Sulfanilamidopyrimidine; Sulfapirimidin; Sulfapyrimidin; Sulfapyrimidine; Sulfatryl; Sulfazine; Sulfolex; Sulfonsol; Sulfose; Sulphadiazine; Terfonyl; Theradiazine; Trifonamide; Trisem; Truozine; Honey diazine; Solfadiazina [DCIT]; Sulfapyrimidin [German]; Sulfonamides Duplex; Sulphadiazine E; Triple Sulfas; Zinc Sulfadiazine; A 306; RP 2616; A-306; Coco-Diazine; Lantrisul (TN); Lipo-Diazine; Lipo-Levazine; Metha-Meridiazine; Neotrizine (TN); Pecta-Diazine; RBPI21 & Sulfa; Sulfadiazina [INN-Spanish]; Sulfadiazine (TN); Sulfadiazine, Zinc; Sulfadiazinum [INN-Latin]; Sulfaloid (TN); Sulfonamides Duplex (TN); Sulfose (TN); Terfonyl (TN); Tri-Sulfameth; Triple Sulfa (TN); Triple Sulfas (TN); Triple Sulfoid (TN); Trisulfapyrimidine, oral suspension; A-306 (VAN); CRL-8131 & Sulfadiazine; Di-Azo-Mul; Mixture of sulfadiazine, sulfamerazine, and sulfamethazine; Pecta-diazine, suspension; S. N. 112; S.N. 112; Sulfadiazine [USAN:INN:JAN]; Thi-Di-Mer; N(1)-2-pyrimidinylsulfanilamide; N(1)-2-pyrimidylsulfanilamide; N(sup 1)-2-Pyrimidinylsulfanilamide; N(sup1)-2-Pyrimidinylsulfanilamide; N(sup1)-2-Pyrimidylsulfanilamide; N-(2-Pyrimidinyl)sulfanilamide; Recombinant bactericidal/permeability-increasing protein & Sulfadiazine; Sulfa-Triple #2 (TN); Sulfadiazine (JAN/USP/INN); N1-(Pyrimidin-2-yl)sulfanilamide; Sulfanilamide, N1-2-pyrimidinyl-(8CI); Adiazin, Adiazine, Debenal, Liquadiazine, Microsulfon, Sulfazine, Sulfolex, Sulfadiazine; 2-Sulfanilamido-pyrimidine; 2-Sulfanilamidopyrimidin; 2-Sulfanilamidopyrimidin [German]; 2-Sulfanilamidopyrimidine; 2-Sulfanilylaminopyrimidine; 2-Sulfapyrimidine; 4-AMINO-N-2-PYRIMIDINYLBENZENESULFONAMIDE; 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide; 4-Amino-N-2-pyrimidinyl-benzenesulfonamide; SDZ
Indication
Disease Entry ICD 11 Status REF
Rheumatic fever 1B40-1B42 Approved [1]
Skin ulcer ME60.Z Approved [2]
Ulcerative colitis DD71 Approved [2]
Chorioretinitis Investigative [2]
Congenital toxoplasmosis Investigative [2]
Therapeutic Class
Antiinfective Agents
Cross-matching ID
PubChem CID
5215
ChEBI ID
CHEBI:9328
CAS Number
CAS 68-35-9
TTD Drug ID
DMTW3R8
INTEDE Drug ID
DR1509
ACDINA Drug ID
D00642

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [9]
Doripenem DM9UCJK Cholecystitis Approved [10]
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [11]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [12]
Sulfisoxazole DMXLT8C Acute otitis media AB00 Approved [13]
Sulfapyridine DMIUYFH Dermatitis herpetiformis EB44 Approved [14]
Gramicidin D DMPT74U Bacterial infection 1A00-1C4Z Approved [15]
Oritavancin DM28D05 Bacterial infection 1A00-1C4Z Approved [10]
Faropenem DMX7A5V Gram-positive bacterial infection 1B74-1G40 Approved [10]
Daptomycin DMFDQ3I Bacterial infection 1A00-1C4Z Approved [16]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
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Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [27]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [28]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [29]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [30]
Mesalazine DMOL5IU Diverticulitis Approved [31]
Allopurinol DMLPAOB Gout FA25 Approved [32]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [33]
Clonazepam DMTO13J Absence epilepsy Approved [34]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [35]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [40]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Estrone DM5T6US Acne vulgaris ED80 Approved [42]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [43]
Ethanol DMDRQZU Chronic pain MG30 Approved [44]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [48]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [49]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [46]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [50]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [68]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [67]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [68]
Sulfinpyrazone DMEV954 Gout FA25 Approved [69]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [67]
Zafirlukast DMHNQOG Asthma CA23 Approved [67]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [67]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [70]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [71]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [4]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [55]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [57]
Estrone DM5T6US Acne vulgaris ED80 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [62]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [63]
Capsaicin DMGMF6V Back pain ME84.Z Approved [64]
Zafirlukast DMHNQOG Asthma CA23 Approved [65]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [62]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [66]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [63]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [62]
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Drug(s) Affected By Lactoperoxidase (LPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [8]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [8]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [8]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [8]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [74]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [8]
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Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [75]
Fluoxetine DM3PD2C Bipolar depression Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [78]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [8]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Aripiprazole DM3NUMH Bipolar I disorder Approved [81]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [85]
Gefitinib DM15F0X Colon adenocarcinoma Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [88]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [91]
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Drug(s) Affected By Glutamate receptor ionotropic, NMDA 1 (GRIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [8]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [8]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [95]
Arsenic DMTL2Y1 N. A. N. A. Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
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Drug(s) Affected By Oligodendrocyte transcription factor 2 (OLIG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [8]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [99]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [74]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [8]
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Drug(s) Affected By SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Selenium DM25CGV N. A. N. A. Approved [101]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [104]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [105]
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Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [106]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [107]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [108]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [112]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [114]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Dihydropteroate synthetase (Bact folP) TT4ILYC DHPS_ECOLI Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [4]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [5]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [6]
RNA cytidine acetyltransferase (hALP) DEZV4AP NAT10_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Biotransformations [7]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Biotransformations [7]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Biotransformations [7]
Glutamate receptor ionotropic, NMDA 1 (GRIN1) OTZ5YBO8 NMDZ1_HUMAN Gene/Protein Processing [8]
Lactoperoxidase (LPO) OTJ9QKX9 PERL_HUMAN Gene/Protein Processing [8]
Oligodendrocyte transcription factor 2 (OLIG2) OTMCN6D3 OLIG2_HUMAN Gene/Protein Processing [8]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Gene/Protein Processing [8]
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) OTSQTPFQ SHAN2_HUMAN Gene/Protein Processing [8]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Gene/Protein Processing [8]

References

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