Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU4ORS)

Drug Name
Magnesium Drug Info
Synonyms
Magnesio; Magnesio [Italian]; Magnesium Matrix Modifier; Magnesium modifier; Magnesium powdered; Magnesium preparation; Magnesium sheet; LTBB002624; Magnesium hydride [UN2010] [Dangerous when wet]; MAGNESIUM NITRATE, ACS; Magnesium nitrate-nitric acid solution; Rieke's active magnesium; MAGNESIUM, ATOMIZED POWDER,18MICRON; Magnesium granules, coated particle size not50% magnesium in pellets, turnings or ribbons [UN1869] [Flammable solid]; Magnesium, powder or magnesium alloys, powder [UN1418] [Dangerous when wet, Spontaneously combustible]; AQUANAL-plus magnesium (Mg) 100-1500 mg/L; AQUANAL(R)-plus magnesium (Mg) 100-1500 mg/L;12Mg
Indication
Disease Entry ICD 11 Status REF
Ischemic stroke 8B11.5Z Approved [1]
Cross-matching ID
PubChem CID
5462224
ChEBI ID
CHEMBL25107
CAS Number
CAS 7439-95-4
TTD Drug ID
DMU4ORS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting N-methyl-D-aspartate receptor (NMDAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [9]
Cycloserine DMT1I52 Bacterial infection 1A00-1C4Z Approved [10]
Benzphetamine DMIJATC Obesity 5B81 Approved [11]
Ketamine DMT5HA4 Anaesthesia 9A78.6 Approved [12]
Felbamate DM1V5ZS Epilepsy 8A60-8A68 Approved [13]
Memantine DMD9WSC Alzheimer disease 8A20 Approved [14]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [15]
Levorphanol DMGS80V Pain MG30-MG3Z Approved [16]
Magnesium Sulfate DMVEK07 Acute pain MG31 Approved [17]
Orphenadrine DMW542E Parkinson disease 8A00.0 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kallikrein-8 (KLK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [6]
Arsenic DMTL2Y1 N. A. N. A. Approved [22]
Magnesium Sulfate DMVEK07 Acute pain MG31 Approved [6]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [23]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [19]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [31]
Pamidronate DMB4AVP Bone Paget disease Approved [32]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
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Drug(s) Affected By Kallikrein-1 (KLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [46]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
AMG 386 DMQJXL4 Breast cancer 2C60-2C65 Phase 3 [5]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [48]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [49]
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Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Panobinostat DM58WKG Chronic graft versus host disease Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [20]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Testosterone enanthate DMB6871 N. A. N. A. Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [55]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [56]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [59]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [60]
Cepharanthine DM9Y5JB N. A. N. A. Approved [61]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [62]
Clozapine DMFC71L Schizophrenia 6A20 Approved [63]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [64]
Trifluoperazine DMKBYWI Anxiety Approved [3]
Olanzapine DMPFN6Y Bipolar depression Approved [63]
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Drug(s) Affected By SPARC (SPARC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [67]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [68]
Ethanol DMDRQZU Chronic pain MG30 Approved [71]
Folic Acid DMEMBJC Colorectal carcinoma Approved [72]
Paclitaxel DMLB81S Breast carcinoma Approved [73]
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Drug(s) Affected By Integrin-binding sialoprotein (IBSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [75]
Calcidiol DMN4CV5 Hypophosphatemia Approved [74]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [76]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [77]
GSK2816126 DMJDVW4 Solid tumour/cancer 2A00-2F9Z Phase 1 [78]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [48]
EUGENOL DM7US1H Discovery agent N.A. Patented [79]
alpha-ketoglutaric acid DM5LFYN Discovery agent N.A. Investigative [80]
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Drug(s) Affected By ADP-ribose pyrophosphatase, mitochondrial (NUDT9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [69]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [55]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [81]
Manganese DMKT129 N. A. N. A. Investigative [2]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [82]
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Drug(s) Affected By Transient receptor potential cation channel subfamily M member 7 (TRPM7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [83]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [84]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [85]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [86]
D-glucose DMMG2TO Discovery agent N.A. Investigative [87]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [88]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
N-methyl-D-aspartate receptor (NMDAR) TT9IK2Z NOUNIPROTAC Antagonist [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ADP-ribose pyrophosphatase, mitochondrial (NUDT9) OTUYF0H3 NUDT9_HUMAN Gene/Protein Processing [2]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [3]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Gene/Protein Processing [4]
Integrin-binding sialoprotein (IBSP) OT29944Y SIAL_HUMAN Gene/Protein Processing [4]
Kallikrein-1 (KLK1) OTFGP3UR KLK1_HUMAN Gene/Protein Processing [5]
Kallikrein-8 (KLK8) OTGVGHXY KLK8_HUMAN Gene/Protein Processing [6]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Gene/Protein Processing [4]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Protein Interaction/Cellular Processes [7]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Gene/Protein Processing [4]
Transient receptor potential cation channel subfamily M member 7 (TRPM7) OTHG1J2G TRPM7_HUMAN Regulation of Drug Effects [8]

References

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66 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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74 Effects of 25-hydroxyvitamin D(3) on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1alpha-hydroxylase. J Bone Miner Res. 2011 May;26(5):1145-53.
75 Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition. Biochem J. 2004 Dec 15;384(Pt 3):591-8. doi: 10.1042/BJ20040380.
76 Potential osteoinductive effects of calcitriol on the m-RNA of mesenchymal stem cells derived from human alveolar periosteum. Biomed Res Int. 2016;2016:3529561.
77 ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.
78 Epigenetic control of skeletal development by the histone methyltransferase Ezh2. J Biol Chem. 2015 Nov 13;290(46):27604-17.
79 Cytotoxic effect of eugenol on the expression of molecular markers related to the osteogenic differentiation of human dental pulp cells. Odontology. 2011 Jul;99(2):188-92. doi: 10.1007/s10266-011-0009-2. Epub 2011 Jun 26.
80 Alpha ketoglutarate exerts a pro-osteogenic effect in osteoblast cell lines through activation of JNK and mTOR/S6K1/S6 signaling pathways. Toxicol Appl Pharmacol. 2019 Jul 1;374:53-64.
81 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
82 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
83 Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells. Int J Mol Med. 2014 Jun;33(6):1657-63. doi: 10.3892/ijmm.2014.1704. Epub 2014 Mar 18.
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85 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
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