Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW3QAK)

Drug Name
NSC-654077 Drug Info
Synonyms
DIBA-1; PD 22551; NSC-654077; PD-22551; PD022551; CHEMBL418037; 171744-39-1; 2,2'-Dithiobis-(N-(4-sulfamoylphenyl)-benzamide); NSC654077; DIBA (Antineoplastic); N-(4-sulfamoylphenyl)-2-[[2-[(4-sulfamoylphenyl)carbamoyl]phenyl]disulfanyl]benzamide; 2,2'-Dithiobis-[N-(4-sulfamoylphenyl)-benzamide]; NSC 654077; N-(4-sulfamoylphenyl)-2-({2-[(4-sulfamoylphenyl)carbamoyl]phenyl}disulfanyl)benzamide; AC1L8BKK; AC1Q6VC8; SCHEMBL6223450; BDBM11052; disulfide-containing sulfonamide 5a
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
375084
ChEBI ID
CHEMBL418037
CAS Number
CAS 171744-39-1
TTD Drug ID
DMW3QAK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [4]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [4]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [5]
Acetazolamide DM1AF5U Absence epilepsy Approved [4]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [6]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [7]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [8]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [6]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Carbonic anhydrase II (CA-II)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [10]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [11]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [12]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [13]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [13]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [14]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [15]
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [16]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [6]
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Drug(s) Targeting Carbonic anhydrase IX (CA-IX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [6]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [7]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [6]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [9]
INDISULAM DM9SX6Y Lymphoma 2A80-2A86 Phase 2 [17]
Girentuximab I-124 DMG3O2Z Renal cell carcinoma 2C90 Phase 2 [18]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [19]
BAY 79-4620 DM14XQN Solid tumour/cancer 2A00-2F9Z Phase 1 [20]
90Y-cG250 DMJR6TC Solid tumour/cancer 2A00-2F9Z Phase 1 [21]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [7]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [22]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
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Drug(s) Affected By Transcription factor E2F1 (E2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [2]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Gefitinib DM15F0X Colon adenocarcinoma Approved [34]
Selenium DM25CGV N. A. N. A. Approved [35]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [42]
Selenium DM25CGV N. A. N. A. Approved [35]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [50]
Leflunomide DMR8ONJ Arthritis FA20 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [52]
Testosterone enanthate DMB6871 N. A. N. A. Approved [53]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [54]
Menthol DMG2KW7 Back pain ME84.Z Approved [55]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [56]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [57]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [2]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Gene/Protein Processing [2]
Retinoblastoma-like protein 2 (RBL2) OTBQSOE6 RBL2_HUMAN Gene/Protein Processing [2]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Gene/Protein Processing [2]

References

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24 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
25 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
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