Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXQS7K)

Drug Name
Cenestin Drug Info
Synonyms
Sodium equilin sulfate; Equilin sodium sulfate; Climopax; Estratab; 16680-47-0; Sodium equilin 3-monosulfate; Emopremarin; Novoconestron; Climestrone; Promarit; Primarin; Premarose; Premaril; Menotrol; Ganeake; Estropan; Estrifol; Premarina; Palopause; Menogen; Mannest; Hyphorin; Formatrix; Estromed; Equigyne; Prempak; Oestrilin; Menotab; Kestrin; Glyestrin; Estroate; Equilin 3-Sulfate Sodium Salt; Conjugen; Conestron; Ayerogen; Theogen; Sukingpo
Indication
Disease Entry ICD 11 Status REF
Menopause symptom GA30.0 Approved [1]
Osteoporosis FB83.0 Approved [1]
Cross-matching ID
PubChem CID
23676225
ChEBI ID
CHEMBL32143
CAS Number
CAS 12126-59-9
TTD Drug ID
DMXQS7K
ACDINA Drug ID
D00248

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [8]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [9]
Estrone DM5T6US Acne vulgaris ED80 Approved [9]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [10]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [10]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [10]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [11]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [12]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [13]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [14]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [15]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [16]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [17]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [18]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [19]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [20]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [21]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [22]
Epinephrine DM3KJBC Acute asthma CA23 Approved [23]
Chlorthalidone DM4DMBT Edema MG29 Approved [24]
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Drug(s) Affected By Follitropin subunit beta (FSHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [25]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [26]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [27]
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [29]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [30]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [31]
Risperidone DMN6DXL Bipolar I disorder Approved [32]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [5]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
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Drug(s) Affected By Lutropin subunit beta (LHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [34]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [37]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [25]
Alprazolam DMC7XDN Anxiety Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [35]
Metoclopramide DMFA5MY Nausea MD90 Approved [37]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [29]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [40]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [44]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [45]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [46]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [47]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [48]
Testosterone DM7HUNW Hot flushes GA30 Approved [49]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
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Drug(s) Affected By Vitamin K-dependent protein S (PROS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desogestrel DM27U4Y Contraception QA21 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Testosterone enanthate DMB6871 N. A. N. A. Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [66]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [71]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [72]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
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Drug(s) Affected By Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Menthol DMG2KW7 Back pain ME84.Z Approved [77]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [78]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [5]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [5]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [79]
Urethane DM7NSI0 N. A. N. A. Phase 4 [80]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [3]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [4]
Follitropin subunit beta (FSHB) OTGLS283 FSHB_HUMAN Gene/Protein Processing [5]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) OTTWCZYM ALS_HUMAN Gene/Protein Processing [5]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Gene/Protein Processing [5]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Gene/Protein Processing [6]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [7]
Vitamin K-dependent protein S (PROS1) OTXQWNOI PROS_HUMAN Gene/Protein Processing [6]

References

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36 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
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60 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
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68 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
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70 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
71 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
72 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
73 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
74 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
75 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
76 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
77 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
78 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
79 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
80 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.