Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYLOVR)

Drug Name
Aciclovir Drug Info
Synonyms
acyclovir; Acycloguanosine; 59277-89-3; Zovirax; Vipral; Virorax; Wellcome-248U; 9-[(2-Hydroxyethoxy)methyl]guanine; Aciclovirum; Zovir; Aciclovirum [Latin]; Sitavig; Aciclovier; Zyclir; 9-HYROXYETHOXYMETHYLGUANINE; Aciclovirum [INN-Latin]; 2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one; W-248-U; 9-(2-Hydroxyethoxy)methylguanine; Acyclovir-side chain-2-3H; ACYCLOVIR SODIUM; 9-((2-Hydroxyethoxy)methyl)guanine; Acicloftal; Cargosil; BW-248U; UNII-X4HES1O11F; DRG-0008; NSC 645011; CHEBI:2453; CCRIS 1953; Iontophoretic acyclovir
Indication
Disease Entry ICD 11 Status REF
Genital herpes 1A94 Approved [1]
Herpes simplex encephalitis Approved [2]
Herpes simplex infection 1F00 Approved [3]
Herpes simplex labialis 1F00.01 Approved [4]
Varicella 1E90 Approved [5]
Virus infection 1A24-1D9Z Approved [6]
Herpes simplex virus infection 1F00 Phase 3 [7]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
135398513
ChEBI ID
CHEMBL184
CAS Number
CAS 59277-89-3
TTD Drug ID
DMYLOVR
VARIDT Drug ID
DR00325
ACDINA Drug ID
D00013

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [20]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [21]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [22]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [8]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [23]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [24]
Famciclovir DMJHLSD Meniere disease AB31.0 Approved [25]
Valacyclovir Hydrochloride DM5I1CE Herpes simplex virus infection 1F00 Approved [8]
Foscavir DM9KJLZ Cytomegalovirus retinitis 9B72.00 Approved [23]
Netivudine DMTKRY1 Virus infection 1A24-1D9Z Phase 3 [26]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Folic Acid DMEMBJC Colorectal carcinoma Approved [29]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [30]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [34]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [35]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [36]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Folic Acid DMEMBJC Colorectal carcinoma Approved [39]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
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Drug(s) Transported By Organic anion transporter 2 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [47]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [51]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [52]
Theophylline DMRJFN9 Bronchitis CA20 Approved [49]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [53]
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Drug(s) Transported By Multidrug and toxin extrusion protein 1 (SLC47A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metformin DM89QE1 Colorectal carcinoma Approved [54]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [14]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [14]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [55]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [14]
Topotecan DMP6G8T Central nervous system neoplasm Approved [14]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [56]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [57]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [58]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [59]
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Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [60]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [64]
Verapamil DMA7PEW Angina pectoris BA40 Approved [65]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [66]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [67]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [68]
Propranolol DM79NTF Angina pectoris BA40 Approved [69]
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Drug(s) Transported By Organic anion transporter 1 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [70]
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [13]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [72]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [73]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [74]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [75]
Tenofovir DM1IS6U Chronic hepatitis B virus infection Approved [76]
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Drug(s) Transported By Organic anion transporter 3 (SLC22A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [78]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [79]
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [80]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [81]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [82]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [83]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [84]
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Drug(s) Transported By Multidrug and toxin extrusion protein 2 (SLC47A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metformin DM89QE1 Colorectal carcinoma Approved [14]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [14]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [14]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [14]
Topotecan DMP6G8T Central nervous system neoplasm Approved [14]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [57]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [58]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [14]
N-methylpyridinium DMVUKEW N. A. N. A. Preclinical [14]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [14]
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Drug(s) Transported By Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [10]
Levacecarnine hci DMJBOCR Cognitive impairment 6D71 Approved [85]
Glycine DMIOZ29 Allergic rhinitis CA08.0 Approved [86]
L-glutamine DM69G8X Short bowel syndrome KB89.1 Approved [87]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [88]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [89]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
D-Serine DM3YH4I N. A. N. A. Phase 4 [91]
L-threonine DMFHTBX Discovery agent N.A. Investigative [91]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [92]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [94]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [95]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [99]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [100]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [17]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [17]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [17]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [17]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [17]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [103]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [104]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [106]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [108]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [110]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [17]
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Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [111]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [112]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [19]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [19]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Modulator [8]
Varicella-zoster virus DNA polymerase (VZV ORF28) TTHPJTK DPOL_VZVD Modulator [9]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTW7AE3 AAAT_HUMAN Substrate [10]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [11]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [12]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [13]
Multidrug and toxin extrusion protein 2 (SLC47A2) DT3TX4H S47A2_HUMAN Substrate [14]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [14]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [15]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [13]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [16]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [17]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Regulation of Drug Effects [18]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [17]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Gene/Protein Processing [19]

References

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12 Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. J Pharmacol Exp Ther. 2003 Aug;306(2):778-86.
13 Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
14 Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
15 Acyclovir is a substrate for the human breast cancer resistance protein (BCRP/ABCG2): implications for renal tubular transport and acyclovir-induced nephrotoxicity. Can J Physiol Pharmacol. 2011 Sep;89(9):675-80.
16 Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs. Drug Metab Dispos. 2012 Mar;40(3):617-24.
17 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
18 Acyclovir is a substrate for the human breast cancer resistance protein (BCRP/ABCG2): implications for renal tubular transport and acyclovir-induced nephrotoxicity. Can J Physiol Pharmacol. 2011 Sep;89(9):675-80. doi: 10.1139/y11-045. Epub 2011 Aug 22.
19 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
20 Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
21 Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81.
22 Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15.
23 Drug targets in cytomegalovirus infection. Infect Disord Drug Targets. 2009 Apr;9(2):201-22.
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27 Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
28 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
29 Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
30 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
31 Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
32 Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
33 Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
34 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
35 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
36 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
37 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
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39 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
40 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
41 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
42 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
43 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
44 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
45 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
46 Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158.
47 Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
48 Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8.
49 Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22.
50 Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82.
51 A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
52 Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter. Drug Metab Pharmacokinet. 2017 Feb;32(1):116-119.
53 Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
54 Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005.
55 Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8.
56 Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6.
57 Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.
58 FDA Drug Development and Drug Interactions
59 Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metab Dispos. 2018 May;46(5):592-599.
60 Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
61 Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86.
62 Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42.
63 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57.
64 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
65 Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
66 Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
67 Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
68 Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53.
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70 The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002 Jan;30(1):13-9.
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82 Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11.
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