Details of the Drug Reposition

General Information of This Drug (ID: DMGEMB7)

• Drug Name: Hydrocortisone (DMGEMB7)
• Synonyms: Acticort; Alacort; Algicirtis; Alphaderm; Amberin; Anflam; Anucort; Aquacort; Cetacort; Chronocort; Cleiton; Cobadex; Colocort; Corhydron; Cortanal; Cortef; Cortenema; Cortesal; Corticreme; Cortifair; Cortifan; Cortiment; Cortisol; Cortisolonum; Cortisporin; Cortispray; Cortolotion; Cortonema; Cortoxide; Cortril; Cremesone; Cutisol; Delacort; Dermacort; Dermaspray; Dermil; Dermocortal; Dermolate; Dihydrocostisone; Dioderm; Drotic; DuoCort; Efcorbin; Efcortelan; Efcortelin; Eldecort; Eldercort; Epicort; Epicortisol; Evacort; Ficortril; Fiocortril; Flexicort; Genacort; Glycort; Hidalone; Hycort; Hycortol; Hycortole; Hydracort; Hydrasson; Hydrocortal; Hydrocorticosterone; Hydrocortisyl; Hydrocortone; Hydroskin; Hydroxycortisone; Hytisone; Hytone; Idrocortisone; Kyypakkaus; Lactisona; Lubricort; Maintasone; Medicort; Meusicort; Mildison; Milliderm; Nutracort; Optef; Otocort; Penecort; Permicort; Prepcort; Proctocort; Protocort; Rectoid; Sanatison; Schericur; Sigmacort; Signef; Stiefcorcil; Synacort; Tarcortin; Texacort; Timocort; Traumaide; Uniderm; Vytone; Zenoxone; ACETASOL HC; Aeroseb HC; AnusolHC; Aquanil HC; Barseb HC; CaldeCORT Spray; Clear aid; Component of Lubricort; Component of Otalgine; Cortisol alcohol; Cortisporin Otico; Ef corlin; Epiderm H; Esiderm H; Foille Insetti; HYDROCORTISONE AND ACETIC ACID; HYDROCORTISONE IN ABSORBASE; Heb Cort; Hydrocortisone alcohol; Hydrocortisone base; Hydrocortisone free alcohol; Hydrocortisone solution; Hytone lotion; Idrocortisone [DCIT]; Komed HC; Lacticare HC; Nogenic HC; ORLEX HC; Pediotic Suspension; Polcort H; Preparation H Hydrocortisone Cream; Prevex HC; Proctozone HC; Remederm HC; Scalpicin Capilar; Scheroson F; Systral Hydrocort; Transderma H; VoSol HC; H 4001; Texacort lotion 25; [3H]cortisol; ACETIC ACID W/ HYDROCORTISONE; Acticort (TN); Aeroseb-HC; Ala-Cort; Ala-Scalp; Anti-inflammatory hormone; Anucort-HC; Anusol HC (TN); Balneol-hc; Basan-Corti; Beta-hc; COR-OTICIN; Colocort (TN); Cort-Dome; Cortef (TN); Cortisol, Hydrocortisone; Cremicort-H; Cyclodextrin-encapsulated hydrocortisone; Derm-Aid; Dome-cort; Domolene-HC; Genacort (lotion); Gyno-Cortisone; H-Cort; HC #1; HC #4; HC (HYDROCORTISONE); Heb-Cort; Hi-cor; Hidro-Colisona; Hidrocortisona [INN-Spanish]; Hydro-Adreson; Hydro-Colisona; Hydro-RX; Hydrocortisone-Water Soluble; Hydrocortisonum [INN-Latin]; Hytone (TN); Incortin-H; Incortin-hydrogen; Kendall's compound F; Lacticare-HC; Neo-Cortef; Neosporin-H Ear; Nystaform-HC; Otosone-F; Rectasol-HC; Reichstein's substance M; Scalp-Cort; Stie-cort; Component of Neo-Cort-Dome; Hydrocortisone [INN:BAN:JAN]; Hydrocortisone (JP15/USP/INN); 11-beta-Hydrocortisone; 11-beta-Hydroxycortisone; 11beta,17,21-Trihydroxyprogesterone; 11beta-Hydrocortisone; 11beta-Hydroxycortisone; 17-Hydroxycorticosterone; 17alpha-Hydroxycorticosterone
• Therapeutic Class: Antiinflammatory Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

41 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Viral pneumonia	DISENI5X	N.A.	Approved	[1]
Serum sickness	DIS0MRKJ	N.A.	Approved	[1]
Rheumatic heart disease	DISCI8JQ	N.A.	Approved	[1]
Primary cutaneous T-cell lymphoma	DIS35WVW	N.A.	Approved	[1]
Malignant otitis externa caused by Pseudomonas aeruginosa	DIS5C8KP	N.A.	Approved	[1]
Keratitis	DISMFOEI	N.A.	Approved	[1]
Granuloma annulare	DISMOUMI	N.A.	Approved	[1]
Gingival disorder	DISD5M1D	N.A.	Approved	[1]
Exanthem	DISAFOQN	N.A.	Approved	[1]
Erythema multiforme	DISKCLM1	N.A.	Approved	[1]
Disorder of orbital region	DISH0ECJ	N.A.	Approved	[1]
Diamond-Blackfan anemia	DISI2SNW	N.A.	Approved	[1]
Bursitis	DISCF7Y9	N.A.	Approved	[1]
Blepharoconjunctivitis	DIS4PG4J	N.A.	Approved	[1]
Aspiration pneumonitis	DIS5S4DE	N.A.	Approved	[1]
Acute adrenal insufficiency	DIS66YLV	N.A.	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	DISM7GNX	1D6Y	Approved	[2]
Tinea cruris	DIS5JC14	1F28.3	Approved	[1]
Mycosis fungoides	DIS62RB8	2B01	Approved	[1]
Autoimmune haemolytic anaemia	DIS7MS3M	3A20	Approved	[1]
Angioedema	DIS90QDN	4A00.15	Approved	[1]
Systemic lupus erythematosus	DISI1SZ7	4A40.0	Approved	[1]
Sarcoidosis	DISE5B8Z	4B20.5	Approved	[1]
Congenital adrenal hyperplasia	DISG873W	5A71.01	Approved	[1]
Addison disease	DIS7HNOH	5A74.0	Approved	[1]
Multiple sclerosis	DISB2WZI	8A40	Approved	[1]
Cerebral edema	DIS4GHSB	8D60.1	Approved	[1]
Corneal ulcer	DIS8YN8N	9A76	Approved	[1]
Allergic rhinitis	DIS3U9HN	CA08.0	Approved	[1]
Severe asthma	DISAVQI3	CA23	Approved	[1]
Proctitis	DIS3K8ZM	DB33.Z	Approved	[1]
Crohn disease	DIS2C5Q8	DD70	Approved	[1]
Ulcerative colitis	DIS8K27O	DD71	Approved	[1]
Inflammatory bowel disease	DISGN23E	DD72	Approved	[1]
Psoriasis	DIS59VMN	EA90	Approved	[1]
Dermatitis herpetiformis	DIS0TC0G	EB44	Approved	[1]
Acne vulgaris	DISKW8PI	ED80	Approved	[1]
Rosacea	DIS02PWG	ED90.0	Approved	[1]
Psoriatic arthritis	DISLWTG2	FA21	Approved	[1]
Corneal abrasion	DIS3SD7J	NA06.4	Approved	[1]
Inflammation	DISJUQ5T	1A00-CA43.1	Approved	[3]

2 Withdrawn Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Pemphigus	DISZAZ6M	N.A.	Withdrawn	[4]
Allergic conjunctivitis	DISZ5ZJN	9A60.02	Withdrawn	[5]

11 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Iritis	DISSA7AC	N.A.	Discontinued in Phase 3	[6]
Tenosynovitis	DISR5H9R	N.A.	Discontinued in Phase 3	[7]
Thyroiditis	DISTCV24	N.A.	Discontinued in Phase 3	[8]
Autoimmune disease	DISORMTM	4A40-4A45	Discontinued in Phase 3	[9]
Anterior uveitis	DISQ7EAD	9A96	Discontinued in Phase 3	[10]
Otitis externa	DISYCORK	AA00-AA13	Discontinued in Phase 3	[11]
Hemorrhoids	DISQ5G6G	DB60	Discontinued in Phase 3	[12]
Atopic dermatitis	DISTCP41	EA80	Discontinued in Phase 3	[13]
Seborrhoeic dermatitis	DISNWVJU	EA81	Discontinued in Phase 3	[14]
Contact dermatitis	DISQ3AU0	EK0Z	Discontinued in Phase 3	[15]
Musculoskeletal disorder	DISPPN0O	FA00-FC0Z	Discontinued in Phase 3	[16]

5 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Nephrotic syndrome	DISSPSC2	N.A.	Discontinued in Phase 2	[17]
Leukemia	DISNAKFL	N.A.	Discontinued in Phase 2	[18]
Aphthous stomatitis	DISR2T25	N.A.	Discontinued in Phase 2	[19]
Acute lymphocytic leukaemia	DISPX75S	2B33.3	Discontinued in Phase 2	[20]
Ankylosing spondylitis	DISRC6IR	FA92.0	Discontinued in Phase 2	[21]

5 Discontinued in Phase 1 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Exfoliative dermatitis	DISQEWIW	N.A.	Discontinued in Phase 1	[22]
Humoral hypercalcemia of malignancy	DISQQ62D	N.A.	Discontinued in Phase 1	[23]
Tendinitis	DISS7ANY	N.A.	Discontinued in Phase 1	[24]
Dermatitis	DISY5SZC	EA80-EA89	Discontinued in Phase 1	[25]
Arthritis	DIST1YEL	FA20	Discontinued in Phase 1	[26]

7 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Trichinellosis	DISUR2ZW	N.A.	Investigative	[1]
Synovitis	DISW2GPY	N.A.	Investigative	[1]
Phobic disorder	DISX6DUL	N.A.	Investigative	[1]
Iridocyclitis	DISV6UP4	N.A.	Investigative	[1]
Classic Hodgkin lymphoma	DISV1LU6	N.A.	Investigative	[1]
Beta-thalassemia major	DISW06BV	N.A.	Investigative	[1]
Acquired thrombocytopenia	DISXH01C	N.A.	Investigative	[1]

References

• [1] Hydrocortisone FDA Label
• [2] Hydrocortisone for COVID-19 and Severe Hypoxia (COVID STEROID)
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2868).
• [4] Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine.
• [5] Chemotherapy and Radiation Therapy With or Without Efaproxiral in Treating Patients With Stage III Non-Small Cell Lung Cancer
• [6] Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer
• [7] Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis
• [8] A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated Diarrhea
• [9] Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors
• [10] TNF Blockade With Remicade in Active Lupus Nephritis WHO Class V (TRIAL )
• [11] Trametinib in Treating Patients With Recurrent or Progressive Low-Grade Ovarian Cancer or Peritoneal Cavity Cancer
• [12] Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal Cancer
• [13] Efficacy of a Low-Molecular-Weight Heparin (Bemiparin) in the Treatment of Chronic Foot Ulcers in Diabetic Patients
• [14] Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide
• [15] Trial of Preemptive Treatment With Oral Valganciclovir Compared With Intravenous (IV) Ganciclovir for Cytomegalovirus Infection After Bone Marrow or Peripheral Blood Stem Cell Transplant
• [16] A Study on Efficacy and Safety of Topiramate in Treatment of Obese Subjects With Dyslipidemia
• [17] A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus
• [18] Double Cord Blood Transplant for Patients With Malignant and Non-malignant Disorders
• [19] Cediranib Maleate With or Without Gefitinib in Treating Patients With Recurrent or Progressive Glioblastoma
• [20] Treating Multiple Sclerosis With Sirolimus, an Immune System Suppressor
• [21] Romidepsin in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors
• [22] ABI-007 With Carboplatin as First-Line Therapy in Patients With Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Carcinoma
• [23] Dasatinib Plus Radiation Therapy/Temozolomide in Newly-Diagnosed Glioblastoma
• [24] Erlotinib Hydrochloride in Treating Non-Small Cell Lung Cancer That is Metastatic or Cannot be Removed by Surgery in Patients With HIV Infection
• [25] Pilot Study of Oxytocin and microRNA Identification in NAF, Serum, and Tissue in Women With Breast Cancer
• [26] Gemcitabine Combined With Mistletoe in Treating Patients With Advanced Solid Tumors