General Information of This Drug (ID: DMS9503)

Drug Name
Benzylpenicillin   DMS9503
Synonyms
penicillin g; Benzylpenicillinic acid; Free penicillin II; Pencillin G; 61-33-6; Benzylpenicillin G; Bencilpenicilina; Benzylpenicillinum; Benzyl penicillin; Free penicillin G; Dropcillin; Pharmacillin; Gelacillin; Liquacillin; Benzopenicillin; Cilopen; Pradupen; Benzylpenicilline; Specilline G; Cilloral; Cosmopen; Ursopen; Galofak; Free benzylpenicillin; Compocillin G; Phenylacetamidopenicillanic acid; 6-(2-Phenylacetamido)penicillanic acid; Pfizerpen; Benzyl-6-aminopenicillinic acid
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
35 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Staphylococcus aureus infection DISK6PTH N.A. Approved [1]
Gonococcal infection of joint DISE12BW N.A. Approved [2]
Meningococcal meningitis DISCKTAT N.A. Approved [3]
Lung abscess DIS15SCZ N.A. Approved [4]
Meningococcemia DIS33W79 N.A. Approved [5]
Pasteurella multocida infectious disease DIS3UASE N.A. Approved [6]
Bacterial endocarditis DIS920N0 N.A. Approved [7]
Gastrointestinal anthrax DIS7DTI1 N.A. Approved [8]
Streptococcal pneumonia DIS2EKMJ N.A. Approved [9]
Erysipelas DISDNXCM N.A. Approved [10]
Streptococcal toxic-shock syndrome DISCVXCW N.A. Approved [11]
Cutaneous anthrax DISA6ECE N.A. Approved [12]
Yaws DISLTH3X N.A. Approved [13]
Erysipelothrix rhusiopathiae infectious disease DISLOCZM N.A. Approved [14]
Rat-bite fever DIS66S0S N.A. Approved [15]
Latent yaws DISHN7UZ N.A. Approved [16]
Pneumococcal meningitis DISM5U0L N.A. Approved [17]
Listeria meningitis DISFUBH8 N.A. Approved [17]
Cervicofacial actinomycosis DIS4AFTN N.A. Approved [18]
Pasteurellosis DISMAQGW N.A. Approved [19]
Neonatal sepsis DIS8Q3VE N.A. Approved [20]
Neurosyphilis DISDBPKD N.A. Approved [21]
Actinomycosis DIS7YFRP N.A. Approved [22]
Latent syphilis DISIAEB7 N.A. Approved [23]
Syphilis DISJ73BS N.A. Approved [24]
Congenital syphilis DISAZL0D N.A. Approved [25]
Inhalational anthrax DISII8HD N.A. Approved [26]
Late latent syphilis DIS0WGPC N.A. Approved [27]
Tertiary lesion of yaws DISI4SS3 N.A. Approved [28]
Botulism DISDY0OZ 1A11 Approved [29]
Anthrax DISFPT78 1B97 Approved [26]
Streptococcus infection DIS04U9T 1B53 Approved [30]
Acute otitis media DISL8D8G AB00 Approved [31]
Respiratory tract infection DIS7OJYM CA45 Approved [32]
Psoriasis DIS59VMN EA90 Approved [33]
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⏷ Show the Full List of 35 Indications(s)
1 Withdrawn Indication(s)
Indication Name Indication ID ICD-11 Status REF
Pinta disease DISZ0SD8 N.A. Withdrawn [34]
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2 Discontinued in Phase 3 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Scarlet fever DISNTLKC N.A. Discontinued in Phase 3 [35]
Pharyngitis DISSN548 CA02.Z Discontinued in Phase 3 [36]
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1 Discontinued in Phase 2 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Streptococcal meningitis DISQ65JM N.A. Discontinued in Phase 2 [37]
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5 Investigative Indication(s)
Indication Name Indication ID ICD-11 Status REF
Latent early syphilis DISVAWKX N.A. Investigative [38]
Tertiary syphilis DISXHT8N N.A. Investigative [39]
Bejel DISVCV9L N.A. Investigative [40]
Secondary syphilis DISXOVHB N.A. Investigative [41]
Tetanus DISVMFVD 1C13 Investigative [42]
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References

1 In vivo synergy between 6 beta-amidinopenicillanic acid derivatives and other antibiotics. Antimicrob Agents Chemother. 1976 Apr;9(4):589-94.
2 Infectious arthritis. Infect Dis Clin North Am. 1990 Sep;4(3):523-38.
3 Meningococcal meningitis and diabetes insipidus. Scand J Infect Dis. 1988;20(3):341-3.
4 Spontaneous Clostridium perfringens lung abscess unresponsive to penicillin. Anaesth Intensive Care. 1993 Feb;21(1):117-9.
5 [An unusual cause of fever: chronic meningococcemia]. Ned Tijdschr Geneeskd. 1996 Apr 6;140(14):785-7.
6 Pasteurella multocida pneumonia. Semin Respir Infect. 1997 Mar;12(1):54-6.
7 Optimisation of the prevention and treatment of bacterial endocarditis. Drugs Aging. 2001;18(6):415-24.
8 Inhalational, gastrointestinal, and cutaneous anthrax in children: a systematic review of cases: 1900 to 2005. Arch Pediatr Adolesc Med. 2007 Sep;161(9):896-905.
9 Pathogenesis, treatment, and prevention of pneumococcal pneumonia. Lancet. 2009 Oct 31;374(9700):1543-56.
10 [Streptococcus pyogenes--much more than the aetiological agent of scarlet fever]. Med Monatsschr Pharm. 2009 Nov;32(11):408-16; quiz 417-8.
11 [Beta-hemolytic streptococcal bacteremia in adults]. Duodecim. 2013;129(14):1477-84.
12 Cutaneous Anthrax. J Emerg Med. 2017 Feb;52(2):240-241.
13 Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. Am J Trop Med Hyg. 2017 May;96(5):1039-1041.
14 Erysipelothrix rhusiopathiae bloodstream infection - A 22-year experience at Mayo Clinic, Minnesota. Zoonoses Public Health. 2017 Nov;64(7):e65-e72.
15 Rat-Bite Fever. 2023 Mar 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
16 Yaws. 2023 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
17 Meningitis in adults: diagnosis and management. Intern Med J. 2018 Nov;48(11):1294-1307.
18 Cervicofacial actinomycosis: a report of 14 patients observed at the Dermatology Unit of the University of Milan, Italy. Int J Dermatol. 2020 Oct;59(10):1222-1225.
19 Pasteurella Multocida. 2023 May 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
20 Antibiotic regimens for early-onset neonatal sepsis. Cochrane Database Syst Rev. 2021 May 17;5(5):CD013837.
21 Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study. Lancet Infect Dis. 2021 Oct;21(10):1441-1447.
22 Abdominal actinomycosis after reparative surgery for cholecystogastric fistula in an immunosuppressed patient. BMJ Case Rep. 2021 Jul 23;14(7):e243445.
23 Diagnosis, treatment, and notification of syphilis during pregnancy in the state of Gois, Brazil, between 2007 and 2017. Rev Saude Publica. 2021 Oct 29;55:68.
24 Diagnosis and treatment of syphilis in pregnant women at the services of Primary Care. Cien Saude Colet. 2022 Aug;27(8):3331-3340.
25 Congenital syphilis in a preterm newborn with gastrointestinal disorders and postnatal growth restriction. Ital J Pediatr. 2022 Dec 29;48(1):205.
26 Human Anthrax: Update of the Diagnosis and Treatment. Diagnostics (Basel). 2023 Mar 10;13(6):1056.
27 Syphilis. Lancet. 2023 Jul 22;402(10398):336-346.
28 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
29 Clinical Serum Therapy: Benefits, Cautions, and Potential Applications. Keio J Med. 2017 Dec 25;66(4):57-64.
30 Prevalence and treatment of group B streptococcus colonization based on risk factors versus intrapartum culture screening. Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:178-181.
31 Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017. J Infect Chemother. 2019 Mar;25(3):229-232.
32 Benzylpenicillin versus wide-spectrum beta-lactam antibiotics as empirical treatment of Haemophilus influenzae-associated lower respiratory tract infections in adults; a retrospective propensity score-matched study. Eur J Clin Microbiol Infect Dis. 2018 Sep;37(9):1761-1775.
33 A review of antibiotics and psoriasis: induction, exacerbation, and amelioration. Expert Rev Clin Pharmacol. 2019 Oct;12(10):981-989.
34 Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes
35 Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and Trastuzumab in Treating Women With Stage III or Stage IV Breast Cancer
36 Maintenance Treatment of Non Segmental Vitiligo With Tacrolimus Ointment 0.1% Versus Control
37 Reduced Dexamethasone Pre-Medication Dose in Elderly Patients Receiving Weekly Docetaxel
38 Syphilis. Enferm Infecc Microbiol Clin (Engl Ed). 2019 Jun-Jul;37(6):398-404.
39 A rare case of tertiary syphilis spondylodiscitis of the upper cervical spine: Diagnostic and therapeutic complexity, review of literature. Orthop Rev (Pavia). 2020 Jun 25;12(Suppl 1):8675.
40 2020 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2021 Mar;35(3):574-588.
41 Secondary Syphilis. Clin Pract Cases Emerg Med. 2020 Nov;4(4):675-676.
42 Benzathine penicillin, metronidazole and benzyl penicillin in the treatment of tetanus: a randomized, controlled trial. Ann Trop Med Parasitol. 2004 Jan;98(1):59-63.