Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7HF4W)

• DTT Name: Cyclin-dependent kinase 2 (CDK2) DTT Info
• Gene Name: CDK2

Molecule-Related Drug & Molecule List

15 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PHA848125	DMS2Q9G	Thymic cancer	2C27	Phase 2	[1]
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[2]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[4]
TG02	DMZFIGQ	Anaplastic astrocytoma	2A00.0	Phase 1/2	[5]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
AT7519	DMCE08M	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
AZD-5438	DMBQ2TF	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
CYC065	DM9ODT6	Lymphoma	2A80-2A86	Phase 1	[8]
FN-1501	DM7BMD6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
PF-07104091	DMMJZ2E	Non-small-cell lung cancer	2C25	Phase 1	[10]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[12]
RGT-419B	DMD2MND	Breast cancer	2C60-2C65	Phase 1	[13]
SNS-032	DMEITAS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[14]

27 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,5-di-substituted pyridine derivative 1	DMEUO8G	N. A.	N. A.	Patented	[15]
4-(thiazol-5-yl)-pyrimidine derivative 1	DM7B81V	N. A.	N. A.	Patented	[15]
4-(thiazol-5-yl)-pyrimidine derivative 2	DMMQFCN	N. A.	N. A.	Patented	[15]
4-amino-3,5-di-substituted-thiazole derivative 1	DMMELYI	N. A.	N. A.	Patented	[15]
5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivative 1	DMHXKFB	N. A.	N. A.	Patented	[15]
Alkyl sulfone derivative 1	DM06U3J	N. A.	N. A.	Patented	[15]
Aniline derivative 1	DMDSUGF	N. A.	N. A.	Patented	[15]
Diamidothiazole derivative 1	DM02V5Q	N. A.	N. A.	Patented	[15]
Diaryl amine derivative 1	DM06MJH	N. A.	N. A.	Patented	[15]
Flavopiridol analog 1	DMXL3A5	N. A.	N. A.	Patented	[15]
Fluorinated compound 1	DMGOSN2	N. A.	N. A.	Patented	[15]
Indole-based analog 11	DMVRX7S	N. A.	N. A.	Patented	[15]
Indole-based analog 13	DMV7DFM	N. A.	N. A.	Patented	[15]
Isoquinoline 1,3-dione derivative 1	DMIYUAN	N. A.	N. A.	Patented	[15]
Isosteric imidazolyl pyrimidine derivative 1	DMP2QDM	N. A.	N. A.	Patented	[15]
N-(pyridin-2-yl)pyridine methylsulfone derivative 1	DM305UL	N. A.	N. A.	Patented	[15]
N-(pyridin-2-yl)pyrimidin-4-amine derivative 2	DMTZ6K9	N. A.	N. A.	Patented	[15]
N-phenyl-pyrimidin-4-amine derivative 1	DMAV8LM	N. A.	N. A.	Patented	[15]
Naphthyridine and isoquinoline derivative 1	DMTGIP7	N. A.	N. A.	Patented	[15]
Nitrogen mustard derivative 1	DMXDSYU	N. A.	N. A.	Patented	[15]
Oxazolyl methylthiothiazole derivative 1	DMZM6FW	N. A.	N. A.	Patented	[15]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[16]
PMID26161698-Compound-25	DM4AFHY	N. A.	N. A.	Patented	[15]
Pyrazolo-triazine derivative 2	DML6V78	N. A.	N. A.	Patented	[15]
Pyrazolo[1,5-a]-1,3,5-triazine derivative 1	DMOK7CW	N. A.	N. A.	Patented	[15]
Pyrrolo[2,3-d]pyrimidine derivative 9	DM0HU5O	N. A.	N. A.	Patented	[15]
Roscovitine derivative 1	DMD1G3Z	N. A.	N. A.	Patented	[15]

6 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SCH 727965	DMCJLD1	Acute lymphoblastic leukaemia	2A85	Discontinued in Phase 3	[2]
BAY 10-00394	DMV2DIW	Small-cell lung cancer	2C25.Y	Discontinued in Phase 2	[17]
R547	DMK25FU	Advanced solid tumour	2A00-2F9Z	Discontinued in Phase 1	[2]
ZK 304709	DMJ9R4A	Advanced solid tumour	2A00-2F9Z	Discontinued in Phase 1	[2]
Olomoucine	DMNAFG1	N. A.	N. A.	Terminated	[19]
PD-0183812	DMWYP86	Retinoblastoma	2D02.2	Terminated	[20]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
INOC-005	DMBQGZ9	Solid tumour/cancer	2A00-2F9Z	Preclinical	[18]
L-751250	DMOERXK	Obesity	5B81	Preclinical	[19]

87 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime	DMGXRSZ	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Chloro-5'-fluoro-indirubin-3'-oxime	DM6AUHR	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Chloro-5'-hydroxy-indirubin-3'-oxime	DMD7WGM	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime	DMZ0V6G	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Fluoro-5'-chloro-indirubin-3'-oxime	DMO7RFL	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Fluoro-5'-fluoro-indirubin-3'-oxime	DMJ4ABD	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Fluoro-5'-hydroxy-indirubin-3'-oxime	DM9LQH1	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Fluoro-5'-methoxy-indirubin-3'-oxime	DMQDH3N	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Fluoro-5'-methyl-indirubin-3'-oxime	DMAS3JC	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Nitro-5'-chloro-indirubin-3'-oxime	DMYLX0U	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Nitro-5'-fluoro-indirubin-3'-oxime	DMXZ2UC	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime	DM0S82C	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Nitro-5'-methoxy-indirubin-3'-oxime	DMLOIUK	Discovery agent	N.A.	Investigative	[21]
(2'Z,3'E)-5-Nitro-5'-methyl-indirubin-3'-oxime	DM6BA5L	Discovery agent	N.A.	Investigative	[21]
1-Amino-6-Cyclohex-3-Enylmethyloxypurine	DM6AV2S	Discovery agent	N.A.	Investigative	[22]
10Z-Hymenialdisine	DMIRSA5	Discovery agent	N.A.	Investigative	[19]
2-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol	DM1BI65	Discovery agent	N.A.	Investigative	[23]
2-Amino-6-Chloropyrazine	DMJVG30	Discovery agent	N.A.	Investigative	[22]
2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE	DMFNEZW	Discovery agent	N.A.	Investigative	[24]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[25]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[25]
3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol	DMJZK40	Discovery agent	N.A.	Investigative	[23]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[25]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[25]
4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine	DME8BLW	Discovery agent	N.A.	Investigative	[22]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[23]
4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide	DMGRWEU	Discovery agent	N.A.	Investigative	[24]
4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline	DMTIA27	Discovery agent	N.A.	Investigative	[26]
5-hydroxynaphthalene-1-sulfonamide	DMMF57V	Discovery agent	N.A.	Investigative	[24]
5-nitroindirubin-3'-oxime	DM4K8N2	Discovery agent	N.A.	Investigative	[21]
6-(3-Amino-benzyloxy)-9H-purin-2-ylamine	DMJ92W0	Discovery agent	N.A.	Investigative	[27]
6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine	DMSW3KN	Discovery agent	N.A.	Investigative	[27]
6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine	DMAYWIN	Discovery agent	N.A.	Investigative	[27]
6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE	DMACTDZ	Discovery agent	N.A.	Investigative	[24]
6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine	DM9IHYS	Discovery agent	N.A.	Investigative	[28]
6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine	DM6UP25	Discovery agent	N.A.	Investigative	[24]
6-O-Cyclohexylmethyl Guanine	DMDIW08	Discovery agent	N.A.	Investigative	[22]
9-Nitropaullone	DM8LUYM	Discovery agent	N.A.	Investigative	[19]
aloisine	DM7HGX8	Discovery agent	N.A.	Investigative	[29]
aloisine A	DM5U1LN	Discovery agent	N.A.	Investigative	[30]
aminopurvalanol A	DMKLC3O	N. A.	N. A.	Investigative	[31]
Benzyl-(9-isopropyl-9H-purin-6-yl)-amine	DMNE1M3	Discovery agent	N.A.	Investigative	[32]
BMS-265246	DM6LPIG	Discovery agent	N.A.	Investigative	[33]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[34]
BOHEMINE	DMLCMA3	Discovery agent	N.A.	Investigative	[32]
BX-795	DMRIMLJ	Discovery agent	N.A.	Investigative	[35]
BX-912	DMZA45C	Discovery agent	N.A.	Investigative	[35]
Cdk1/2 inhibitor III	DMS62T0	Discovery agent	N.A.	Investigative	[36]
Cdk4 inhibitor III	DMNZJAX	Discovery agent	N.A.	Investigative	[37]
CVT-313	DMSEK5W	Discovery agent	N.A.	Investigative	[38]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[22]
GW-8510	DML4UMT	Discovery agent	N.A.	Investigative	[39]
Indirubin-3'-monoxime	DMLRQH0	Discovery agent	N.A.	Investigative	[19]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[19]
JNJ-7706621	DMHTYBS	Discovery agent	N.A.	Investigative	[40]
K00024	DMP8M9Q	Discovery agent	N.A.	Investigative	[41]
Lysine Nz-Carboxylic Acid	DMW1YK3	Discovery agent	N.A.	Investigative	[22]
MERIOLIN 1	DMJT93H	Discovery agent	N.A.	Investigative	[42]
MERIOLIN 2	DM413XJ	Discovery agent	N.A.	Investigative	[42]
MERIOLIN 3	DMVE95S	Discovery agent	N.A.	Investigative	[42]
MERIOLIN 4	DMIJMZQ	Discovery agent	N.A.	Investigative	[42]
MERIOLIN 5	DMGVLR0	Discovery agent	N.A.	Investigative	[42]
MERIOLIN 6	DMW5AXC	Discovery agent	N.A.	Investigative	[42]
MERIOLIN 8	DM0E95B	Discovery agent	N.A.	Investigative	[42]
N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE	DM2D4KY	Discovery agent	N.A.	Investigative	[24]
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide	DMUFVM6	Discovery agent	N.A.	Investigative	[43]
N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide	DMOMYDV	Discovery agent	N.A.	Investigative	[24]
N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide	DM9JCD3	Discovery agent	N.A.	Investigative	[22]
N-phenyl-1H-pyrazole-3-carboxamide	DMP5E1G	Discovery agent	N.A.	Investigative	[24]
NSC-625987	DMLG05U	Discovery agent	N.A.	Investigative	[44]
NU-6027	DMELYAX	Discovery agent	N.A.	Investigative	[28]
NU-6102	DMMOFKD	Discovery agent	N.A.	Investigative	[45]
NU6140	DMCUSG3	Discovery agent	N.A.	Investigative	[46]
Oxindole 95	DM4UL1G	Discovery agent	N.A.	Investigative	[19]
PF-228	DM32FKD	Discovery agent	N.A.	Investigative	[47]
PHA-690509	DMNS70E	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]
PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE	DMHVW61	Discovery agent	N.A.	Investigative	[24]
PMID18986805C9b	DMFU6AI	Discovery agent	N.A.	Investigative	[49]
PMID19115845C89S	DMB9F2L	Discovery agent	N.A.	Investigative	[50]
Purvalanol A	DMNQ7TM	Discovery agent	N.A.	Investigative	[51]
PYRAZOLOPYRIDAZINE 1	DMKTB5U	Discovery agent	N.A.	Investigative	[52]
PYRAZOLOPYRIDAZINE 2	DMI7AUJ	Discovery agent	N.A.	Investigative	[52]
RESCOVITINE	DM2IBND	Discovery agent	N.A.	Investigative	[53]
SCH-546909	DMMXIB4	Solid tumour/cancer	2A00-2F9Z	Investigative	[38]
SU9516	DMQHG0R	Discovery agent	N.A.	Investigative	[19]
TRIAZOLOPYRIMIDINE	DM5ZBF3	Discovery agent	N.A.	Investigative	[24]
VER-54505	DMYD7P5	Solid tumour/cancer	2A00-2F9Z	Investigative	[38]

References

• [1] Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor. J Med Chem. 2009 Aug 27;52(16):5152-63.
• [2] Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
• [3] A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
• [4] ClinicalTrials.gov (NCT04541225) Phase 1/2 Dose Escalation, Safety, Pharmacokinetics, and Efficacy Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors. U.S.National Institutes of Health.
• [5] Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42.
• [6] Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Mol Cancer Ther. 2009 Feb;8(2):324-32.
• [7] AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells.Int J Radiat Oncol Biol Phys.2012 Nov 15;84(4):e507-14.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518.
• [10] ClinicalTrials.gov (NCT04553133) PF-07104091 as a Single Agent and in Combination Therapy. U.S. National Institutes of Health.
• [11] A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected h... Cell Cycle. 2011 Mar 15;10(6):963-70.
• [12] Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75.
• [13] Clinical pipeline report, company report or official report of Regor Therapeutics
• [14] Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45.
• [15] Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
• [16] c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.
• [17] National Cancer Institute Drug Dictionary (drug id 770319).
• [18] What are next generation innovative therapeutic targets. J Pharmacol Exp Ther. 2009 Jul;330(1):304-15.
• [19] Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25.
• [20] Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16.
• [21] 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706.
• [22] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [23] 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9.
• [24] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [25] Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81.
• [26] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [27] Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem. 2002 Aug 1;45(16):3381-93.
• [28] 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003 Jan 20;13(2):217-22.
• [29] Identification of binding specificity-determining features in protein families. J Med Chem. 2012 Mar 8;55(5):1926-39.
• [30] Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.
• [31] A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.
• [32] Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2. J Med Chem. 2000 Jun 29;43(13):2506-13.
• [33] A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. Mol Cancer Ther. 2011 Feb;10(2):242-54.
• [34] Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43.
• [35] Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74.
• [36] 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11.
• [37] 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.
• [38] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1973).
• [39] Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7.
• [40] Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41.
• [41] Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem. 2003 May 22;46(11):2027-30.
• [42] Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51.
• [43] Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.
• [44] The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86.
• [45] Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity. J Med Chem. 2006 Sep 7;49(18):5470-7.
• [46] Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37.
• [47] Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52.
• [48] Discovery of drug mode of action and drug repositioning from transcriptional responses. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14621-6.
• [49] Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6486-9.
• [50] First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307.
• [51] The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
• [52] N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular effi... J Med Chem. 2004 Sep 9;47(19):4716-30.
• [53] Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors. Eur J Med Chem. 2010 Mar;45(3):1158-66.