Details of Disease

General Information of Disease (ID: DIS2OKP1)

• Disease Name: Delirium
• Synonyms: organic brain syndrome; OBS syndrome
• Definition: A disorder characterized by confusion; inattentiveness; disorientation; illusions; hallucinations; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)
• Disease Hierarchy:
  DISH2ERD: Cognitive impairment
  DIS2OKP1: Delirium
• Disease Identifiers:
  MONDO ID: MONDO_0045057
  MESH ID: D003693
  UMLS CUI: C0011206
  MedGen ID: 41445
  HPO ID: HP:0031258
  SNOMED CT ID: 2776000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Haloperidol	DM96SE0	Approved	Small molecular drug	[1]
Quetiapine	DM1N62C	Approved	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 9 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BCHE	TT3MSAO	moderate	Altered Expression	[3]
CIT	TT3BKTU	Strong	Biomarker	[4]
DRD2	TTEX248	Strong	Biomarker	[5]
DRD3	TT4C8EA	Strong	Biomarker	[5]
FGL2	TTYBS89	Strong	Biomarker	[6]
HCRT	TTU5HJP	Strong	Altered Expression	[7]
MTNR1B	TT32JK8	Strong	Genetic Variation	[8]
TH	TTUHP71	Strong	Biomarker	[9]
HTR2C	TTWJBZ5	Definitive	Genetic Variation	[10]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A13	DTDSYAQ	Strong	Genetic Variation	[11]

This Disease Is Related to 21 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BTBD8	OT3A3RD7	moderate	Genetic Variation	[12]
CALM2	OTNYA92F	Strong	Biomarker	[13]
CAMKMT	OTLJBRUW	Strong	Biomarker	[13]
CNOT1	OTTEU05F	Strong	Biomarker	[14]
CORO7	OTG7MEAJ	Strong	Biomarker	[15]
KRIT1	OT58AP1I	Strong	Biomarker	[13]
MCF2L	OTEURA8N	Strong	Genetic Variation	[16]
NEFL	OTQESJV4	Strong	Biomarker	[17]
NLRP6	OTEREN4W	Strong	Biomarker	[18]
PNN	OT0HXICH	Strong	Genetic Variation	[19]
SASS6	OT1V8H40	Strong	Biomarker	[20]
SRPX	OT5B9LXS	Strong	Genetic Variation	[19]
ADAMTS2	OTTK22NO	Definitive	Biomarker	[21]
BCS1L	OT5PY5CY	Definitive	Genetic Variation	[22]
GABBR1	OTU5A52J	Definitive	Genetic Variation	[23]
GRIN3A	OTQS9GYY	Definitive	Genetic Variation	[24]
PELI1	OTMLBCLC	Definitive	Genetic Variation	[25]
PRDM6	OTKY12D9	Definitive	Genetic Variation	[25]
RRAGA	OTKISLG4	Definitive	Biomarker	[26]
SARNP	OTE0OVK5	Definitive	Genetic Variation	[9]
THOC1	OTVABJ4Z	Definitive	Genetic Variation	[9]

References

• [1] Haloperidol FDA Label
• [2] Quetiapine FDA Label
• [3] Relevance of peripheral cholinesterase activity on postoperative delirium in adult surgical patients (CESARO): A prospective observational cohort study.Eur J Anaesthesiol. 2019 Feb;36(2):114-122. doi: 10.1097/EJA.0000000000000888.
• [4] Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees.Age Ageing. 2018 Jan 1;47(1):61-68. doi: 10.1093/ageing/afx149.
• [5] Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium.Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):38-45. doi: 10.1002/ajmg.b.30943.
• [6] Serum soluble fibrinogen-like protein 2 concentration predicts delirium after acute pancreatitis.Brain Behav. 2019 Apr;9(4):e01261. doi: 10.1002/brb3.1261. Epub 2019 Mar 18.
• [7] Effect of Suvorexant on Nocturnal Delirium in Elderly Patients with Alzheimer's Disease: A Case-series Study.Clin Psychopharmacol Neurosci. 2019 Nov 20;17(4):547-550. doi: 10.9758/cpn.2019.17.4.547.
• [8] Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium?.PLoS One. 2018 Nov 27;13(11):e0207941. doi: 10.1371/journal.pone.0207941. eCollection 2018.
• [9] Short tandem repeat (STR) replacements in UTRs and introns suggest an important role for certain STRs in gene expression and disease.Gene. 2005 Jan 3;344:203-11. doi: 10.1016/j.gene.2004.09.034. Epub 2004 Dec 7.
• [10] Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability.Am J Med Genet. 1999 Apr 16;88(2):126-30.
• [11] SLC25A13 c.1610_1612delinsAT mutation in an Indian patient and literature review of 79 cases of citrin deficiency for genotype-phenotype associations.Gene. 2018 Aug 20;668:190-195. doi: 10.1016/j.gene.2018.05.076. Epub 2018 May 19.
• [12] Functional Status in Older Intensive Care Unit Survivors.Clin Nurs Res. 2020 Jan;29(1):5-12. doi: 10.1177/1054773818785860. Epub 2018 Jul 19.
• [13] Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area.BMJ Open. 2019 Feb 24;9(2):e024259. doi: 10.1136/bmjopen-2018-024259.
• [14] Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study.Lancet Respir Med. 2018 Mar;6(3):213-222. doi: 10.1016/S2213-2600(18)30062-6.
• [15] Perioperative Dexmedetomidine Reduces Delirium in Elderly Patients after Lung Cancer Surgery.Psychiatr Danub. 2019 Mar;31(1):95-101. doi: 10.24869/psyd.2019.95.
• [16] Neuropsychiatric complications and neuroimaging characteristics after deep brain stimulation surgery for Parkinson's disease.Brain Imaging Behav. 2020 Feb;14(1):62-71. doi: 10.1007/s11682-018-9971-4.
• [17] Postoperative delirium is associated with increased plasma neurofilament light.Brain. 2020 Jan 1;143(1):47-54. doi: 10.1093/brain/awz354.
• [18] Incremental cost and length of stay associated with postprocedure delirium in transcatheter and surgical aortic valve replacement patients in the United States.Catheter Cardiovasc Interv. 2019 May 1;93(6):1132-1136. doi: 10.1002/ccd.28014. Epub 2018 Dec 14.
• [19] Accuracy of the Delirium Observational Screening Scale (DOS) as a screening tool for delirium in patients with advanced cancer.BMC Cancer. 2019 Feb 19;19(1):160. doi: 10.1186/s12885-019-5351-8.
• [20] Sedation Practice in Extracorporeal Membrane Oxygenation-Treated Patients with Acute Respiratory Distress Syndrome: A Retrospective Study.ASAIO J. 2018 Jul/Aug;64(4):544-551. doi: 10.1097/MAT.0000000000000658.
• [21] Music therapy and Alzheimer's disease: Cognitive, psychological, and behavioural effects.Neurologia. 2017 Jun;32(5):300-308. doi: 10.1016/j.nrl.2015.12.003. Epub 2016 Feb 17.
• [22] Validation of the Stanford Proxy Test for Delirium (S-PTD) among critical and noncritical patients.J Psychosom Res. 2018 Nov;114:8-14. doi: 10.1016/j.jpsychores.2018.08.009. Epub 2018 Aug 30.
• [23] Association analysis of exonic variants of the gene encoding the GABAB receptor and alcohol dependence.Psychiatr Genet. 1999 Jun;9(2):69-73. doi: 10.1097/00041444-199906000-00004.
• [24] The assessment of the T102C polymorphism of the 5HT2a receptor gene, 3723G/A polymorphism of the NMDA receptor 3A subunit gene (GRIN3A) and 421C/A polymorphism of the NMDA receptor 2B subunit gene (GRIN2B) among cardiac surgery patients with and without delirium.Gen Hosp Psychiatry. 2014 Nov-Dec;36(6):753-6. doi: 10.1016/j.genhosppsych.2014.06.002. Epub 2014 Jun 14.
• [25] CE: Original Research: Recognizing Delirium in Hospitalized Children: A Systematic Review of the Evidence on Risk Factors and Characteristics.Am J Nurs. 2018 Apr;118(4):24-36. doi: 10.1097/01.NAJ.0000532069.55339.f9.
• [26] Comparison of regional with general anaesthesia on postoperative delirium (RAGA-delirium) in the older patients undergoing hip fracture surgery: study protocol for a multicentre randomised controlled trial.BMJ Open. 2017 Oct 22;7(10):e016937. doi: 10.1136/bmjopen-2017-016937.