Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTLJBRUW)

DOT Name Calmodulin-lysine N-methyltransferase (CAMKMT)
Synonyms CLNMT; CaM KMT; EC 2.1.1.60
Gene Name CAMKMT
Related Disease
Adult glioblastoma ( )
Glioblastoma multiforme ( )
Adenocarcinoma ( )
Alzheimer disease ( )
Arrhythmia ( )
Bipolar disorder ( )
Bladder cancer ( )
Breast cancer ( )
Breast carcinoma ( )
Carcinoma ( )
Cerebral cavernous malformation ( )
Colon cancer ( )
Colon carcinoma ( )
Colorectal carcinoma ( )
Delirium ( )
Depression ( )
Endometrial carcinoma ( )
Epithelial ovarian cancer ( )
Gastric cancer ( )
Hypotonia-cystinuria syndrome ( )
Inborn disorder of amino acid transport ( )
Lymphoma ( )
Metastatic malignant neoplasm ( )
Multiple sclerosis ( )
Non-hodgkin lymphoma ( )
Ovarian cancer ( )
Ovarian neoplasm ( )
Prostate cancer ( )
Prostate carcinoma ( )
Renal cell carcinoma ( )
Rheumatoid arthritis ( )
Schizophrenia ( )
Small-cell lung cancer ( )
Stomach cancer ( )
Systemic lupus erythematosus ( )
Urinary bladder cancer ( )
Urinary bladder neoplasm ( )
X-linked hydrocephalus with stenosis of the aqueduct of Sylvius ( )
Mitochondrial myopathy ( )
Advanced cancer ( )
Glioma ( )
Hepatitis C virus infection ( )
Lymphoma, non-Hodgkin, familial ( )
Neuroblastoma ( )
Renal carcinoma ( )
UniProt ID
CMKMT_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
PDB ID
4PWY
EC Number
2.1.1.60
Pfam ID
PF10294
Sequence
MESRVADAGTGETARAAGGSPAVGCTTRGPVVSAPLGAARWKLLRQVLKQKHLDDCLRHV
SVRRFESFNLFSVTEGKERETEEEVGAWVQYTSIFCPEYSISLRHNSGSLNVEDVLTSFD
NTGNVCIWPSEEVLAYYCLKHNNIFRALAVCELGGGMTCLAGLMVAISADVKEVLLTDGN
EKAIRNVQDIITRNQKAGVFKTQKISSCVLRWDNETDVSQLEGHFDIVMCADCLFLDQYR
ASLVDAIKRLLQPRGKAMVFAPRRGNTLNQFCNLAEKAGFCIQRHENYDEHISNFHSKLK
KENPDIYEENLHYPLLLILTKHG
Function Catalyzes the trimethylation of 'Lys-116' in calmodulin.
Tissue Specificity
Isoform 1 is expressed in brain, liver, muscle colon and lung. Isoform 2 is expressed in colon, testis, kidney and brain. Isoform 1 and isoform 2 are expressed in normal lymphoblastoid cells but not in lymphoblastoid cells from patients with hypotonia-cystinuria syndrome.
KEGG Pathway
Lysine degradation (hsa00310 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Protein methylation (R-HSA-8876725 )
Inactivation, recovery and regulation of the phototransduction cascade (R-HSA-2514859 )

Molecular Interaction Atlas (MIA) of This DOT

45 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Adult glioblastoma DISVP4LU Definitive Biomarker [1]
Glioblastoma multiforme DISK8246 Definitive Biomarker [1]
Adenocarcinoma DIS3IHTY Strong Altered Expression [2]
Alzheimer disease DISF8S70 Strong Biomarker [3]
Arrhythmia DISFF2NI Strong Genetic Variation [4]
Bipolar disorder DISAM7J2 Strong Genetic Variation [5]
Bladder cancer DISUHNM0 Strong Biomarker [6]
Breast cancer DIS7DPX1 Strong Biomarker [7]
Breast carcinoma DIS2UE88 Strong Biomarker [7]
Carcinoma DISH9F1N Strong Biomarker [7]
Cerebral cavernous malformation DISLKNYA Strong Biomarker [8]
Colon cancer DISVC52G Strong Biomarker [9]
Colon carcinoma DISJYKUO Strong Biomarker [9]
Colorectal carcinoma DIS5PYL0 Strong Altered Expression [2]
Delirium DIS2OKP1 Strong Biomarker [10]
Depression DIS3XJ69 Strong Genetic Variation [11]
Endometrial carcinoma DISXR5CY Strong Biomarker [12]
Epithelial ovarian cancer DIS56MH2 Strong Biomarker [13]
Gastric cancer DISXGOUK Strong Genetic Variation [14]
Hypotonia-cystinuria syndrome DISUPMRI Strong Biomarker [15]
Inborn disorder of amino acid transport DIS1BLHT Strong Biomarker [16]
Lymphoma DISN6V4S Strong Biomarker [17]
Metastatic malignant neoplasm DIS86UK6 Strong Altered Expression [2]
Multiple sclerosis DISB2WZI Strong Genetic Variation [18]
Non-hodgkin lymphoma DISS2Y8A Strong Biomarker [19]
Ovarian cancer DISZJHAP Strong Biomarker [13]
Ovarian neoplasm DISEAFTY Strong Biomarker [13]
Prostate cancer DISF190Y Strong Biomarker [20]
Prostate carcinoma DISMJPLE Strong Biomarker [20]
Renal cell carcinoma DISQZ2X8 Strong Altered Expression [21]
Rheumatoid arthritis DISTSB4J Strong Biomarker [22]
Schizophrenia DISSRV2N Strong Altered Expression [23]
Small-cell lung cancer DISK3LZD Strong Biomarker [24]
Stomach cancer DISKIJSX Strong Genetic Variation [14]
Systemic lupus erythematosus DISI1SZ7 Strong Biomarker [22]
Urinary bladder cancer DISDV4T7 Strong Biomarker [6]
Urinary bladder neoplasm DIS7HACE Strong Biomarker [6]
X-linked hydrocephalus with stenosis of the aqueduct of Sylvius DIS6QXIR Strong Genetic Variation [25]
Mitochondrial myopathy DIS9SA7V moderate Biomarker [16]
Advanced cancer DISAT1Z9 Limited Biomarker [26]
Glioma DIS5RPEH Limited Biomarker [27]
Hepatitis C virus infection DISQ0M8R Limited Biomarker [28]
Lymphoma, non-Hodgkin, familial DISCXYIZ Limited Biomarker [19]
Neuroblastoma DISVZBI4 Limited Biomarker [29]
Renal carcinoma DISER9XT Limited Biomarker [30]
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⏷ Show the Full List of 45 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
6 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Calmodulin-lysine N-methyltransferase (CAMKMT). [31]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Calmodulin-lysine N-methyltransferase (CAMKMT). [32]
Quercetin DM3NC4M Approved Quercetin decreases the expression of Calmodulin-lysine N-methyltransferase (CAMKMT). [33]
Testosterone enanthate DMB6871 Approved Testosterone enanthate affects the expression of Calmodulin-lysine N-methyltransferase (CAMKMT). [34]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the expression of Calmodulin-lysine N-methyltransferase (CAMKMT). [35]
Formaldehyde DM7Q6M0 Investigative Formaldehyde decreases the expression of Calmodulin-lysine N-methyltransferase (CAMKMT). [36]
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⏷ Show the Full List of 6 Drug(s)

References

1 Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells.Oncotarget. 2017 May 20;8(57):96697-96709. doi: 10.18632/oncotarget.18043. eCollection 2017 Nov 14.
2 L-CAM expression in lymph node and liver metastases of colorectal carcinomas.J Pathol. 1994 Feb;172(2):177-81. doi: 10.1002/path.1711720204.
3 Modulating Conformation of A-Peptide: An Effective Way to Prevent Protein-Misfolding Disease.Inorg Chem. 2018 Nov 5;57(21):13533-13543. doi: 10.1021/acs.inorgchem.8b02115. Epub 2018 Oct 22.
4 Protein phenotype diagnosis of autosomal dominant calmodulin mutations causing irregular heart rhythms.J Cell Biochem. 2018 Nov;119(10):8233-8248. doi: 10.1002/jcb.26834. Epub 2018 Jun 22.
5 Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.PLoS Genet. 2011 Jun;7(6):e1002134. doi: 10.1371/journal.pgen.1002134. Epub 2011 Jun 30.
6 Suppression of human bladder cancer growth by increased expression of C-CAM1 gene in an orthotopic model.Cancer Res. 1996 Aug 1;56(15):3431-5.
7 Expression and prognostic value of L1-CAM in breast cancer.Oncol Rep. 2009 Nov;22(5):1109-17. doi: 10.3892/or_00000543.
8 Chemoenzymatic Synthesis of O-Mannose Glycans Containing Sulfated or Nonsulfated HNK-1 Epitope.J Am Chem Soc. 2019 Dec 11;141(49):19351-19359. doi: 10.1021/jacs.9b08964. Epub 2019 Dec 2.
9 Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.Cancer Res. 2007 Aug 15;67(16):7703-12. doi: 10.1158/0008-5472.CAN-07-0991.
10 Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area.BMJ Open. 2019 Feb 24;9(2):e024259. doi: 10.1136/bmjopen-2018-024259.
11 Alterations in cell adhesion molecule L1 and functionally related genes in major depression: a postmortem study.Biol Psychiatry. 2005 Apr 1;57(7):716-25. doi: 10.1016/j.biopsych.2004.12.016.
12 The prognostic significance of positive peritoneal cytology in endometrial cancer and its correlations with L1-CAM biomarker.Surg Oncol. 2019 Mar;28:151-157. doi: 10.1016/j.suronc.2019.01.001. Epub 2019 Jan 5.
13 L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice.PLoS One. 2016 Jan 13;11(1):e0146885. doi: 10.1371/journal.pone.0146885. eCollection 2016.
14 Clinical Application of the DiversiLab Microbial Typing System Using Repetitive Sequence-Based PCR for Characterization of Helicobacter pylori in Japan.J Clin Lab Anal. 2015 May;29(3):250-3. doi: 10.1002/jcla.21758. Epub 2014 May 5.
15 PREPL deficiency: delineation of the phenotype and development of a functional blood assay. Genet Med. 2018 Jan;20(1):109-118. doi: 10.1038/gim.2017.74. Epub 2017 Jul 20.
16 Calmodulin Methyltransferase Is Required for Growth, Muscle Strength, Somatosensory Development and Brain Function.PLoS Genet. 2015 Aug 6;11(8):e1005388. doi: 10.1371/journal.pgen.1005388. eCollection 2015 Aug.
17 Expression of far upstream element binding protein1 in Bcell nonHodgkin lymphoma is correlated with tumor growth and celladhesion mediated drug resistance.Mol Med Rep. 2016 Oct;14(4):3759-68. doi: 10.3892/mmr.2016.5718. Epub 2016 Sep 6.
18 A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.Genes Immun. 2014 Mar;15(2):126-32. doi: 10.1038/gene.2013.70. Epub 2014 Jan 16.
19 Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.Hematology. 2017 Oct;22(9):527-535. doi: 10.1080/10245332.2017.1312205. Epub 2017 Apr 10.
20 Function and therapeutic implication of C-CAM cell-adhesion molecule in prostate cancer.Semin Oncol. 1999 Apr;26(2):227-33.
21 Anti-neuroblastoma antibody chCE7 binds to an isoform of L1-CAM present in renal carcinoma cells.Int J Cancer. 1999 Oct 29;83(3):401-8. doi: 10.1002/(sici)1097-0215(19991029)83:3<401::aid-ijc17>3.0.co;2-a.
22 Influence of treatments on cell adhesion molecules in patients with systemic lupus erythematosus and rheumatoid arthritis: a review.Inflammopharmacology. 2020 Apr;28(2):363-384. doi: 10.1007/s10787-019-00674-6. Epub 2019 Dec 9.
23 Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.Mol Psychiatry. 2011 Mar;16(3):286-92. doi: 10.1038/mp.2010.7. Epub 2010 Feb 16.
24 Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway.PLoS One. 2010 Apr 20;5(4):e10243. doi: 10.1371/journal.pone.0010243.
25 Nine novel L1 CAM mutations in families with X-linked hydrocephalus.Hum Mutat. 1997;9(6):512-8. doi: 10.1002/(SICI)1098-1004(1997)9:6<512::AID-HUMU3>3.0.CO;2-3.
26 Cancer Biomarkers for Integrative Oncology.Curr Oncol Rep. 2019 Mar 5;21(4):32. doi: 10.1007/s11912-019-0782-6.
27 CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics.Cancer Res. 2005 Dec 1;65(23):10930-7. doi: 10.1158/0008-5472.CAN-05-1890.
28 Comparison of conventional PCR with real-time PCR and branched DNA-based assays for hepatitis C virus RNA quantification and clinical significance for genotypes 1 to 5.J Clin Microbiol. 2006 Mar;44(3):729-37. doi: 10.1128/JCM.44.3.729-737.2006.
29 SPARC overexpression combined with radiation retards angiogenesis by suppressing VEGF-A via miR?10 in human neuroblastoma cells.Int J Oncol. 2016 Oct;49(4):1394-406. doi: 10.3892/ijo.2016.3646. Epub 2016 Aug 3.
30 The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.Carcinogenesis. 2011 Nov;32(11):1713-23. doi: 10.1093/carcin/bgr195. Epub 2011 Aug 30.
31 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
32 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
33 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
34 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
35 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
36 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.