Details of Disease

General Information of Disease (ID: DISGQ59Y)

• Disease Name: Bulimia nervosa
• Synonyms: bulimia; hyperorexia nervosa
• Disease Class: 6B81: Bulimia nervosa
• Definition: A disorder characterized by recurrent episodes of binge-eating over which the individual feels a lack of control; these episodes of binge-eating are followed by recurrent compensatory behavior to prevent weight gain, usually self-induced vomiting. In addition, self-evaluation is unduly influenced by body image.
• Disease Hierarchy:
  DISVGXN0: Eating disorder
  DISGQ59Y: Bulimia nervosa
• ICD Code:
  ICD-11: ICD-11: 6B81
  ICD-10: ICD-10: F50.2, F50.3
• Disease Identifiers:
  MONDO ID: MONDO_0005452
  MESH ID: D052018
  UMLS CUI: C2267227
  MedGen ID: 389218
  SNOMED CT ID: 78004001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acetylcysteine	DMWSXI4	Approved	Small molecular drug	[1]
Fluoxetine	DM3PD2C	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
OPC-14523	DMB1WF3	Phase 2	Small molecular drug	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 12 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
COMT	TTKWFB8	Limited	Biomarker	[4]
HTR1B	TTK8CXU	Limited	Biomarker	[5]
CIT	TT3BKTU	Strong	Biomarker	[6]
GHRL	TT1OCL0	Strong	Biomarker	[7]
GHSR	TTWDC17	Strong	Genetic Variation	[8]
HTR2A	TTJQOD7	Strong	Genetic Variation	[9]
HTR2C	TTWJBZ5	Strong	Genetic Variation	[10]
HTR3A	TTPC4TU	Strong	Biomarker	[11]
HTR3B	TTR6K75	Strong	Biomarker	[11]
MBOAT4	TTSYOWR	Strong	Genetic Variation	[8]
MC4R	TTD0CIQ	Strong	Genetic Variation	[12]
PYY	TTVFJLX	Strong	Biomarker	[13]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
FAAH	DEUM1EX	Strong	Genetic Variation	[14]
SCLY	DEH4TD6	Strong	Genetic Variation	[15]

This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DST	OTHZBM4X	Limited	Biomarker	[16]
ATP8A2	OTDZC2ZT	Strong	Biomarker	[17]
CHODL	OTVCNOUQ	Strong	Genetic Variation	[17]
CTNNBIP1	OTX9SBJG	Strong	Biomarker	[18]
KRT7	OTLT3JFN	Strong	Genetic Variation	[15]
SYTL5	OTE7OYQC	Strong	Biomarker	[17]
TAL1	OTX4K6QZ	Strong	Genetic Variation	[15]

References

• [1] Acetylcysteine FDA Label
• [2] Fluoxetine FDA Label
• [3] Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66.
• [4] Association of COMT Val158Met Polymorphism with Psychopathological Symptoms in Patients with Eating Disorders.Curr Mol Med. 2018;18(1):65-70. doi: 10.2174/1566524018666180608090512.
• [5] A family-based association study of the HTR1B gene in eating disorders.Braz J Psychiatry. 2016 Jul-Sep;38(3):239-42. doi: 10.1590/1516-4446-2016-1936.
• [6] Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology.World J Biol Psychiatry. 2002 Jul;3(3):133-46. doi: 10.3109/15622970209150614.
• [7] Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED).Physiol Behav. 2008 Aug 6;94(5):696-9. doi: 10.1016/j.physbeh.2008.04.013. Epub 2008 Apr 13.
• [8] Ghrelin gene variants and eating disorders.Vitam Horm. 2013;92:107-23. doi: 10.1016/B978-0-12-410473-0.00004-0.
• [9] Impact of the -1438G>a polymorphism in the serotonin 2A receptor gene on anthropometric profile and obesity risk: a case-control study in a Spanish Mediterranean population.Appetite. 2008 Mar-May;50(2-3):260-5. doi: 10.1016/j.appet.2007.07.011. Epub 2007 Aug 3.
• [10] Contribution of the serotoninergic system to anxious and depressive traits that may be partially responsible for the phenotypical variability of bulimia nervosa.J Psychiatr Res. 2008 Jan;42(1):50-7. doi: 10.1016/j.jpsychires.2006.09.001. Epub 2006 Oct 20.
• [11] Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders.Pharmacogenet Genomics. 2009 Oct;19(10):790-9. doi: 10.1097/FPC.0b013e32833132b3.
• [12] Melanocortin-4 receptor gene variants are not associated with binge-eating behavior in nonobese patients with eating disorders.Psychiatr Genet. 2015 Feb;25(1):35-8. doi: 10.1097/YPG.0000000000000065.
• [13] Acipimox Administration With Exercise Induces a Co-feedback Action of the GH, PP, and PYY on Ghrelin Associated With a Reduction of Peripheral Lipolysis in Bulimic and Healthy-Weight Czech Women: A Randomized Study.Front Endocrinol (Lausanne). 2019 Mar 12;10:108. doi: 10.3389/fendo.2019.00108. eCollection 2019.
• [14] Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.Genes Brain Behav. 2009 Oct;8(7):728-32. doi: 10.1111/j.1601-183X.2009.00518.x. Epub 2009 Jun 26.
• [15] Exercise Obsession and Compulsion in Adults With Longstanding Eating Disorders: Validation of the Norwegian Version of the Compulsive Exercise Test.Front Psychol. 2019 Oct 22;10:2370. doi: 10.3389/fpsyg.2019.02370. eCollection 2019.
• [16] The dexamethasone suppression test in bulimia: nonsuppression associated with depression and suboptimal weight.J Clin Psychiatry. 1988 Mar;49(3):94-6.
• [17] Genetic variants associated with disordered eating.Int J Eat Disord. 2013 Sep;46(6):594-608. doi: 10.1002/eat.22133. Epub 2013 Apr 9.
• [18] The effects of psychotherapy treatment on outcome in bulimia nervosa: Examining indirect effects through emotion regulation, self-directed behavior, and self-discrepancy within the mediation model.Int J Eat Disord. 2017 Jun;50(6):636-647. doi: 10.1002/eat.22669. Epub 2017 Jan 24.