Details of Disease

General Information of Disease (ID: DISJ0JW3)

• Disease Name: Anal intraepithelial neoplasia
• Synonyms: epithelial dysplasia; intraepithelial neoplasia; intraepithelial neoplasm
• Disease Class: 2E92: Digestive organ benign neoplasm
• Definition: A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as low grade (mild dysplasia) or high grade (moderate or severe dysplasia).
• Disease Hierarchy:
  DISV06FL: Precancerous condition
  DIS0T594: Epithelial neoplasm
  DISJ0JW3: Anal intraepithelial neoplasia
• ICD Code:
  ICD-11: ICD-11: 2E92.5
  ICD-10: ICD-10: D12, D12.9
• Disease Identifiers:
  MONDO ID: MONDO_0024474
  MESH ID: D002278
  UMLS CUI: C0878500
  MedGen ID: 164203
  HPO ID: HP:0032187
  SNOMED CT ID: 61313004

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BCG65-E7	DMAMFXC	Discontinued in Phase 3	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CLDN18	TT6PKBX	Strong	Altered Expression	[2]
FGF8	TTIUF3J	Strong	Biomarker	[3]
SLC1A5	TTF7WRM	Strong	Biomarker	[4]
SLC39A6	TTZN1CF	Strong	Altered Expression	[5]
PTGS2	TTVKILB	Definitive	Altered Expression	[6]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
TGM3	DEOEB3Q	Strong	Altered Expression	[7]

This Disease Is Related to 24 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FRAT1	OT1PS84E	moderate	Altered Expression	[8]
AMER1	OT8EFJPM	Strong	Biomarker	[9]
ARHGEF28	OT3F32IU	Strong	Biomarker	[10]
CENPH	OTPOO9LK	Strong	Altered Expression	[11]
DPH1	OT0QU3JY	Strong	Altered Expression	[12]
DUSP4	OT6WAO12	Strong	Biomarker	[13]
FAM3C	OTBR6U9G	Strong	Altered Expression	[14]
IP6K1	OTKS4P2T	Strong	Biomarker	[15]
KRT13	OTTYSKGX	Strong	Altered Expression	[16]
KRT16	OTGA0EQN	Strong	Genetic Variation	[17]
KRT4	OT24PHPM	Strong	Altered Expression	[16]
LDHB	OT9B1CT3	Strong	Altered Expression	[18]
LGALS7	OTMSVI7R	Strong	Biomarker	[19]
LMO4	OT5NDCT9	Strong	Biomarker	[20]
MMP20	OT16S5S3	Strong	Biomarker	[21]
MMP25	OT3BG37V	Strong	Biomarker	[21]
MUC6	OTPVL723	Strong	Altered Expression	[22]
PDHX	OTG7O271	Strong	Biomarker	[23]
PDLIM7	OTAZVODU	Strong	Altered Expression	[24]
PKHD1	OTAH8SMF	Strong	Genetic Variation	[25]
RRM2B	OTE8GBUR	Strong	Altered Expression	[26]
STIL	OT9799VN	Strong	Biomarker	[27]
CFL1	OTT6D5MH	Definitive	Altered Expression	[28]
CLDN1	OT27KV99	Definitive	Biomarker	[29]

References

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• [13] Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma.Cancer Res. 2016 May 1;76(9):2612-25. doi: 10.1158/0008-5472.CAN-15-1846. Epub 2016 Mar 3.
• [14] Overexpression of FAM3C is associated with poor prognosis in oral squamous cell carcinoma.Pathol Res Pract. 2019 Apr;215(4):772-778. doi: 10.1016/j.prp.2019.01.019. Epub 2019 Jan 14.
• [15] Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.Cell Signal. 2016 Aug;28(8):1124-36. doi: 10.1016/j.cellsig.2016.04.011. Epub 2016 Apr 30.
• [16] Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis.Histopathology. 2011 Mar;58(4):531-42. doi: 10.1111/j.1365-2559.2011.03759.x. Epub 2011 Mar 3.
• [17] Clinical and histopathologic prognostic implications of the expression of cytokeratins 8, 10, 13, 14, 16, 18 and 19 in oral and oropharyngeal squamous cell carcinoma.Arch Oral Biol. 2019 Mar;99:1-8. doi: 10.1016/j.archoralbio.2018.12.007. Epub 2018 Dec 16.
• [18] LDHB and FABP4 are Associated With Progression and Poor Prognosis of Pancreatic Ductal Adenocarcinomas.Appl Immunohistochem Mol Morphol. 2017 May/Jun;25(5):351-357. doi: 10.1097/PAI.0000000000000306.
• [19] Roles of galectin-7 and S100A9 in cervical squamous carcinoma: Clinicopathological and in vitro evidence.Int J Cancer. 2013 Mar 1;132(5):1051-9. doi: 10.1002/ijc.27764. Epub 2012 Aug 28.
• [20] Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer.Proc Natl Acad Sci U S A. 2005 May 24;102(21):7659-64. doi: 10.1073/pnas.0502990102. Epub 2005 May 16.
• [21] Matrix metalloproteinase 20-dentin sialophosphoprotein interaction in oral cancer.J Dent Res. 2015 Apr;94(4):584-93. doi: 10.1177/0022034515570156. Epub 2015 Feb 9.
• [22] Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.Gastroenterology. 2002 Oct;123(4):1052-60. doi: 10.1053/gast.2002.36018.
• [23] Calorie restriction delays the progression of lesions to pancreatic cancer in the LSL-KrasG12D; Pdx-1/Cre mouse model of pancreatic cancer.Exp Biol Med (Maywood). 2013 Jul;238(7):787-97. doi: 10.1177/1535370213493727. Epub 2013 Jul 4.
• [24] Detection of Epstein-Barr virus genome and latent infection gene expression in normal epithelia, epithelial dysplasia, and squamous cell carcinoma of the oral cavity.Tumour Biol. 2016 Mar;37(3):3389-404. doi: 10.1007/s13277-015-4167-7. Epub 2015 Oct 8.
• [25] Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers.J Clin Oncol. 2016 Jun 10;34(17):2010-9. doi: 10.1200/JCO.2015.64.0730. Epub 2016 Apr 25.
• [26] Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma.Cancer Lett. 2003 Feb 20;190(2):233-43. doi: 10.1016/s0304-3835(02)00588-8.
• [27] Does the vaginal microbiota play a role in the development of cervical cancer?.Transl Res. 2017 Jan;179:168-182. doi: 10.1016/j.trsl.2016.07.004. Epub 2016 Jul 15.
• [28] Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance.World J Surg Oncol. 2018 Jan 18;16(1):11. doi: 10.1186/s12957-018-1316-7.
• [29] Joint detection of claudin-1 and junctional adhesion molecule-A as a therapeutic target in oral epithelial dysplasia and oral squamous cell carcinoma.J Cell Biochem. 2019 Oct;120(10):18117-18127. doi: 10.1002/jcb.29115. Epub 2019 Jun 3.