Details of Disease

General Information of Disease (ID: DISJQTX1)

Disease Name	Acidosis
Synonyms	acidosis
Disease Class	5C73: Acidosis
Definition	An abnormally high acidity of the blood and other body tissues. Acidosis can be either respiratory or metabolic.
Disease Hierarchy	DISPMVDD: Disorder of acid-base balance DIS71G5H: Metabolic disorder DISJQTX1: Acidosis
ICD Code	ICD-11 ICD-11: 5C73 ICD-10 ICD-10: E87.2 Expand ICD-11 '5C73 Expand ICD-10 'E87.2
Disease Identifiers	MONDO ID MONDO_0006022 MESH ID D000138 UMLS CUI C0001122 MedGen ID 1296 HPO ID HP:0001941 SNOMED CT ID 51387008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Sodium lactate	DMWU1AT	Approved	Small molecular drug	[1]
Tromethamine	DMOBLGK	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADM	TTV14YH	moderate	Biomarker	[3]
NFE2L2	TTA6ZN2	moderate	Biomarker	[4]
CPS1	TT42M75	Strong	Biomarker	[5]
OTC	TT5KIO9	Strong	Biomarker	[5]
SLC12A7	TTU2PCD	Strong	Biomarker	[6]
SLC26A4	TT7X02I	Strong	Biomarker	[7]
SLC6A14	TTB6H2S	Strong	Biomarker	[8]
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⏷ Show the Full List of 7 DTT(s)

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC34A1	DT42EWA	moderate	Biomarker	[9]
SLC9A4	DTU8PXI	moderate	Biomarker	[10]
KCNK2	DTENHUP	Strong	Biomarker	[11]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP27B1	DE3FYEM	Strong	Biomarker	[12]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AMT	OTQYEWZQ	Strong	Biomarker	[13]
CLDN14	OTS7GKOI	Strong	Biomarker	[14]
GPR65	OTCF5O4G	Definitive	Biomarker	[15]
PDP1	OT82RTMT	Definitive	Biomarker	[16]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7328).
3	Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats.Crit Care Med. 2007 Mar;35(3):912-8. doi: 10.1097/01.CCM.0000257327.61829.34.
4	NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.Sci Rep. 2018 Apr 4;8(1):5629. doi: 10.1038/s41598-018-24000-2.
5	Alterations in renal and hepatic nitrogen metabolism in rats during HCl ingestion.Metabolism. 1998 Feb;47(2):163-7. doi: 10.1016/s0026-0495(98)90214-1.
6	Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.Nature. 2002 Apr 25;416(6883):874-8. doi: 10.1038/416874a.
7	Regulation of the apical Cl-/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis.Am J Physiol Renal Physiol. 2003 Jan;284(1):F103-12. doi: 10.1152/ajprenal.00205.2002. Epub 2002 Aug 13.
8	Stimulation of intestinal glutamine absorption in chronic metabolic acidosis.Surgery. 2004 Aug;136(2):127-34. doi: 10.1016/j.surg.2004.04.005.
9	The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins.Am J Physiol Renal Physiol. 2009 Aug;297(2):F499-509. doi: 10.1152/ajprenal.90489.2008. Epub 2009 May 13.
10	NHE4 is critical for the renal handling of ammonia in rodents.J Clin Invest. 2010 Jun;120(6):1895-904. doi: 10.1172/JCI36581. Epub 2010 May 17.
11	Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: physiological impact in acidosis and alkalosis.Am J Physiol Cell Physiol. 2004 Feb;286(2):C272-82. doi: 10.1152/ajpcell.00334.2003. Epub 2003 Oct 1.
12	Metabolic acidosis suppresses 25-hydroxyvitamin in D3-1alpha-hydroxylase in the rat kidney. Distinct site and mechanism of action.J Clin Invest. 1982 Jul;70(1):135-40. doi: 10.1172/jci110586.
13	Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis.Biochem J. 1985 Oct 15;231(2):477-80. doi: 10.1042/bj2310477.
14	Chronic metabolic acidosis upregulated claudin mRNA expression in the duodenal enterocytes of female rats.Life Sci. 2007 Apr 17;80(19):1729-37. doi: 10.1016/j.lfs.2007.01.063. Epub 2007 Mar 2.
15	Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor.J Biol Chem. 2005 Mar 11;280(10):9083-7. doi: 10.1074/jbc.M407832200. Epub 2004 Dec 23.
16	Pyruvate dehydrogenase phosphatase deficiency: a cause of congenital chronic lactic acidosis in infancy.Pediatr Res. 1975 Dec;9(12):935-9. doi: 10.1203/00006450-197512000-00015.