Details of Disease

General Information of Disease (ID: DISLRVLT)

• Disease Name: Carotid artery disease
• Synonyms: carotid artery segment disease; disorder of carotid artery segment; carotid artery disorder; disorder of carotid artery; carotid artery segment disease or disorder; disease of carotid artery segment; disease or disorder of carotid artery segment
• Disease Class: 8B10: Transient ischaemic attack
• Definition: A disease involving the carotid artery segment.
• Disease Hierarchy:
  DISAB237: Cerebrovascular disease
  DISLG4XS: Arterial disorder
  DISWD40R: Disease
  DISLRVLT: Carotid artery disease
• ICD Code:
  ICD-11: ICD-11: 8B10
  ICD-10: ICD-10: G45.1
  Expand ICD-11: '8B10
  Expand ICD-10: 'G45.1
• Disease Identifiers:
  MONDO ID: MONDO_0005269
  MESH ID: D002340
  UMLS CUI: C0007273
  MedGen ID: 2892
  SNOMED CT ID: 371160000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Vitamin E	DMZC90K	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 1 Patented Agent(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Antibodie derivative 9	DMDRJ31	Patented	Antibody	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 13 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
APOE	TTKS9CB	moderate	Genetic Variation	[3]
CD163	TTTZ9DE	moderate	Biomarker	[4]
GSTP1	TT40K12	moderate	Biomarker	[5]
HMOX1	TTI6V2A	moderate	Biomarker	[6]
PLAU	TTGY7WI	moderate	Therapeutic	[7]
AGER	TTMO9HF	Strong	Biomarker	[8]
AGT	TT5C0UB	Strong	Biomarker	[9]
CCL2	TTNAY0P	Strong	Altered Expression	[10]
EGFL7	TT7WD0H	Strong	Altered Expression	[11]
FASLG	TTO7014	Strong	Biomarker	[12]
LTB4R	TTN53ZF	Strong	Biomarker	[13]
PLTP	TTZF6SN	Strong	Altered Expression	[14]
TNFSF4	TTBW580	Definitive	Biomarker	[15]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC39A2	DTL8VXO	Definitive	Biomarker	[16]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MRAS	OTNCVCQW	moderate	Biomarker	[17]
CELSR2	OTON6JSZ	Strong	Genetic Variation	[3]
FGB	OT6RKLI9	Strong	Biomarker	[18]
NANOS3	OTGX9IQU	Strong	Genetic Variation	[19]
PODXL	OTPNQXF3	Strong	Biomarker	[20]
PSRC1	OT7MDJMN	Strong	Genetic Variation	[3]
TOMM40	OTZDQ29F	Strong	Genetic Variation	[3]
SHOC1	OTP51XIP	Definitive	Biomarker	[16]

References

• [1] Riboflavin FDA Label
• [2] VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004.
• [3] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.Lipids Health Dis. 2009 Dec 1;8:52. doi: 10.1186/1476-511X-8-52.
• [4] Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques.Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):154-60. doi: 10.1161/01.ATV.0000251991.64617.e7. Epub 2006 Nov 9.
• [5] Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan.Atherosclerosis. 2007 Jun;192(2):305-12. doi: 10.1016/j.atherosclerosis.2006.07.029. Epub 2006 Sep 14.
• [6] Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque.Circulation. 2009 Jun 16;119(23):3017-27. doi: 10.1161/CIRCULATIONAHA.108.808618. Epub 2009 Jun 1.
• [7] Predictors of clinical improvement, angiographic recanalization, and intracranial hemorrhage after intra-arterial thrombolysis for acute ischemic stroke.Stroke. 1999 Oct;30(10):2094-100. doi: 10.1161/01.str.30.10.2094.
• [8] Regulation of -amyloid level in the brain of rats with cerebrovascular hypoperfusion.Neurobiol Aging. 2012 Apr;33(4):826.e31-42. doi: 10.1016/j.neurobiolaging.2011.05.027. Epub 2011 Aug 3.
• [9] Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment. Clin Sci (Lond). 2003 Nov;105(5):637-44. doi: 10.1042/CS20030156.
• [10] Ets2 determines the inflammatory state of endothelial cells in advanced atherosclerotic lesions.Circ Res. 2011 Aug 5;109(4):382-95. doi: 10.1161/CIRCRESAHA.111.243444. Epub 2011 Jun 23.
• [11] Expression of Egfl7 and miRNA-126-5p in Symptomatic Carotid Artery Disease.Genet Test Mol Biomarkers. 2016 Mar;20(3):125-9. doi: 10.1089/gtmb.2015.0252. Epub 2016 Jan 22.
• [12] Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: normalization by atorvastatin. J Am Coll Cardiol. 2004 Apr 7;43(7):1188-94. doi: 10.1016/j.jacc.2003.10.046.
• [13] Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17501-6. doi: 10.1073/pnas.0505845102. Epub 2005 Nov 17.
• [14] PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity.J Lipid Res. 2015 Jul;56(7):1351-62. doi: 10.1194/jlr.P058032. Epub 2015 May 25.
• [15] Association of OX40L polymorphisms with sporadic breast cancer in northeast Chinese Han population.PLoS One. 2012;7(8):e41277. doi: 10.1371/journal.pone.0041277. Epub 2012 Aug 3.
• [16] Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.Biofactors. 2015 Nov-Dec;41(6):414-23. doi: 10.1002/biof.1247. Epub 2015 Dec 8.
• [17] New susceptibility locus for coronary artery disease on chromosome 3q22.3.Nat Genet. 2009 Mar;41(3):280-2. doi: 10.1038/ng.307. Epub 2009 Feb 8.
• [18] TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects.Hum Genet. 2007 Mar;121(1):65-75. doi: 10.1007/s00439-006-0289-8. Epub 2006 Nov 18.
• [19] Methylentetrahydrofolate reductase and nitric oxide synthase polymorphism in patients with atherosclerosis and diabetes.Pathol Oncol Res. 2009 Dec;15(4):631-7. doi: 10.1007/s12253-009-9163-z. Epub 2009 Mar 29.
• [20] Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes.PLoS One. 2011;6(10):e26025. doi: 10.1371/journal.pone.0026025. Epub 2011 Oct 7.