Details of Disease

General Information of Disease (ID: DISRK7TS)

• Disease Name: Cutaneous leishmaniasis
• Synonyms: zone of skin leishmaniasis; Asian desert cutaneous leishmaniasis; leproid leishmaniasis
• Definition: Leishmaniasis affecting the skin. It is the most common form of leishmaniasis. It presents with erythematous macules and papules, and nodules which may eventually ulcerate. The lesions appear in the bite site in the exposed skin areas.
• Disease Hierarchy:
  DISABTW7: Leishmaniasis
  DISQ7L5A: Parasitic skin disorder
  DISRK7TS: Cutaneous leishmaniasis
• Disease Identifiers:
  MONDO ID: MONDO_0005446
  MESH ID: D016773
  UMLS CUI: C0023283
  MedGen ID: 9715
  SNOMED CT ID: 240637006

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TNF	TTF8CQI	Limited	Altered Expression	[1]
SLC5A1	TT2UE56	Disputed	Genetic Variation	[2]
IL10	TTT0Q1F	moderate	Altered Expression	[3]
CCL2	TTNAY0P	Strong	Altered Expression	[3]
CD1A	TTBGTFN	Strong	Biomarker	[4]
F12	TTRJSMV	Strong	Biomarker	[5]
FDPS	TTIKWV4	Strong	Biomarker	[6]
IL4R	TTDWHC3	Strong	Genetic Variation	[7]
MMP2	TTLM12X	Strong	Biomarker	[8]
PGD	TTZ3IFB	Strong	Genetic Variation	[9]
CPB1	TT4UJX5	Definitive	Biomarker	[10]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCA3	DT2T6VQ	Strong	Altered Expression	[11]

This Disease Is Related to 14 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CXCL3	OTSL94KH	Disputed	Biomarker	[12]
TOLLIP	OTYEO4NR	Disputed	Genetic Variation	[13]
FLI1	OT0EV3LX	moderate	Altered Expression	[14]
AADAC	OT8VACT2	Strong	Genetic Variation	[15]
CEACAM8	OTLL9WWO	Strong	Altered Expression	[16]
CLEC4D	OTT7X1UC	Strong	Biomarker	[17]
CYTB	OTAHB98A	Strong	Genetic Variation	[18]
DPAGT1	OTYEJAGZ	Strong	Genetic Variation	[19]
FAM20C	OTW5YZ7X	Strong	Biomarker	[20]
FBXW4	OTEGSZOX	Strong	Genetic Variation	[15]
H1-0	OTRLJK4Z	Strong	Biomarker	[21]
NLRP10	OTDNZDA0	Strong	Biomarker	[22]
PRDX2	OTLWCY9T	Strong	Biomarker	[23]
LMLN	OTQF0JPY	Definitive	Altered Expression	[24]

References

• [1] Leishmania braziliensis Infection Enhances Toll-Like Receptors 2 and 4 Expression and Triggers TNF- and IL-10 Production in Human Cutaneous Leishmaniasis.Front Cell Infect Microbiol. 2019 May 2;9:120. doi: 10.3389/fcimb.2019.00120. eCollection 2019.
• [2] Identification and phylogenetic relationship of Iranian strains of various Leishmania species isolated from cutaneous and visceral cases of leishmaniasis based on N-acetylglucosamine-1-phosphate transferase gene.Infect Genet Evol. 2014 Aug;26:203-12. doi: 10.1016/j.meegid.2014.05.026. Epub 2014 Jun 7.
• [3] Histological and immunological differences between zoonotic cutaneous leishmaniasis due to Leishmania major and sporadic cutaneous leishmaniasis due to Leishmania infantum.Parasite. 2019;26:9. doi: 10.1051/parasite/2019007. Epub 2019 Feb 27.
• [4] Histopathologic features of cutaneous leishmaniasis and use of CD1a staining for amastigotes in Old World and New World leishmaniasis.J Cutan Pathol. 2017 Dec;44(12):1005-1011. doi: 10.1111/cup.13032. Epub 2017 Sep 15.
• [5] Direct diagnosis of Leishmania species on serosity materials punctured from cutaneous leishmaniasis patients using PCR-RFLP.J Clin Lab Anal. 2011;25(1):20-4. doi: 10.1002/jcla.20377.
• [6] Farnesyl pyrophosphate synthase is essential for the promastigote and amastigote stages in Leishmania major.Mol Biochem Parasitol. 2019 Jun;230:8-15. doi: 10.1016/j.molbiopara.2019.03.001. Epub 2019 Mar 26.
• [7] Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis.Infect Immun. 2018 Nov 20;86(12):e00710-18. doi: 10.1128/IAI.00710-18. Print 2018 Dec.
• [8] Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression.Clin Exp Immunol. 2011 Feb;163(2):207-14. doi: 10.1111/j.1365-2249.2010.04285.x. Epub 2010 Nov 22.
• [9] Cutaneous leishmaniasis caused by Leishmania donovani in the tribal population of the Agasthyamala Biosphere Reserve forest, Western Ghats, Kerala, India.J Med Microbiol. 2015 Feb;64(Pt 2):157-163. doi: 10.1099/jmm.0.076695-0. Epub 2014 Dec 5.
• [10] Recombinant Cysteine Proteinase B from Leishmania braziliensis and Its Domains: Promising Antigens for Serodiagnosis of Cutaneous and Visceral Leishmaniasis in Dogs.J Clin Microbiol. 2019 Oct 23;57(11):e00819-19. doi: 10.1128/JCM.00819-19. Print 2019 Nov.
• [11] Functional Validation of ABCA3 as a Miltefosine Transporter in Human Macrophages: IMPACT ON INTRACELLULAR SURVIVAL OF LEISHMANIA (VIANNIA) PANAMENSIS.J Biol Chem. 2016 Apr 29;291(18):9638-47. doi: 10.1074/jbc.M115.688168. Epub 2016 Feb 22.
• [12] Chronicity of dermal leishmaniasis caused by Leishmania panamensis is associated with parasite-mediated induction of chemokine gene expression.Infect Immun. 2014 Jul;82(7):2872-80. doi: 10.1128/IAI.01133-13. Epub 2014 Apr 21.
• [13] Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil.PLoS Negl Trop Dis. 2015 Jun 24;9(6):e0003875. doi: 10.1371/journal.pntd.0003875. eCollection 2015.
• [14] Analysis of expression of FLI1 and MMP1 in American cutaneous leishmaniasis caused by Leishmania braziliensis infection.Infect Genet Evol. 2017 Apr;49:212-220. doi: 10.1016/j.meegid.2017.01.018. Epub 2017 Jan 21.
• [15] Salvage therapy with Sodium chlorosum (formerly DAC N-055) for cases of refractory lupoid cutaneous leishmaniasis: results from a compassionate use study with 0.09% Sodium chlorosum in amphiphilic basic cream.BMC Infect Dis. 2019 Nov 28;19(1):1005. doi: 10.1186/s12879-019-4518-x.
• [16] Leishmania braziliensis isolated from disseminated leishmaniasis patients downmodulate neutrophil function.Parasite Immunol. 2019 May;41(5):e12620. doi: 10.1111/pim.12620.
• [17] Liposomal amphotericin B in travelers with cutaneous and muco-cutaneous leishmaniasis: Not a panacea.PLoS Negl Trop Dis. 2017 Nov 20;11(11):e0006094. doi: 10.1371/journal.pntd.0006094. eCollection 2017 Nov.
• [18] An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies.PLoS Negl Trop Dis. 2018 Mar 1;12(3):e0006255. doi: 10.1371/journal.pntd.0006255. eCollection 2018 Mar.
• [19] Genetic polymorphism in Leishmania infantum isolates from human and animals determined by nagt PCR-RFLP.Infect Dis Poverty. 2018 Jun 14;7(1):54. doi: 10.1186/s40249-018-0439-y.
• [20] Parasitological and biochemical studies on cutaneous leishmaniasis in Shara'b District, Taiz, Yemen.Ann Clin Microbiol Antimicrob. 2017 Jul 4;16(1):47. doi: 10.1186/s12941-017-0224-y.
• [21] Protection against cutaneous leishmaniasis in outbred vervet monkeys using a recombinant histone H1 antigen.J Infect Dis. 2003 Oct 15;188(8):1250-7. doi: 10.1086/378677. Epub 2003 Oct 1.
• [22] An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.J Immunol. 2017 Oct 15;199(8):2823-2833. doi: 10.4049/jimmunol.1500832. Epub 2017 Sep 20.
• [23] Comparative Assessment of Induced Immune Responses Following Intramuscular Immunization with Fusion and Cocktail of LeIF, LACK and TSA Genes Against Cutaneous Leishmaniasis in BALB/c Mice.Arch Immunol Ther Exp (Warsz). 2018 Feb;66(1):55-64. doi: 10.1007/s00005-017-0484-4. Epub 2017 Aug 4.
• [24] AIM2 inflammasome is associated with disease severity in tegumentary leishmaniasis caused by Leishmania (V.) braziliensis.Parasite Immunol. 2017 Jul;39(7). doi: 10.1111/pim.12435. Epub 2017 May 29.