Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTAYGHDM)

• DOT Name: Probable E3 ubiquitin-protein ligase MARCHF10 (MARCHF10)
• Synonyms: EC 2.3.2.27; Membrane-associated RING finger protein 10; Membrane-associated RING-CH protein X; MARCH-X; RING finger protein 190; RING-type E3 ubiquitin transferase MARCHF10
• Gene Name: MARCHF10
• Related Disease:
  Type-1/2 diabetes
  Arteriosclerosis
  Atherosclerosis
  Classic Hodgkin lymphoma
  Myocardial infarction
  Obesity
  Respiratory failure
  Schizophrenia
  Stroke
  Urinary tract infection
  Nervous system disease
  Tuberous sclerosis
• UniProt ID: MARHA_HUMAN
• EC Number: 2.3.2.27
• Pfam ID: PF12906
• Sequence:
  MLHDARDRQKFFSDVQYLRDMQHKVDSEYQACLRRQEYRRDPNEKKRDQFWGQETSFERS
  RFSSRSSSKQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKV
  DPSEPSPADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQ
  VVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQ
  GKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEEC
  LWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAM
  EPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENV
  WSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSA
  LRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFA
  VREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTP
  FTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCR
  ICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLV
  DLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHNQVERERLSRN
  YPQPRTEENENSELGDGNEGSISQSQVV
• Function: E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Molecular Interaction Atlas (MIA) of This DOT

12 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Type-1/2 diabetes	DISIUHAP	Definitive	Biomarker	[1]
Arteriosclerosis	DISK5QGC	Strong	Genetic Variation	[2]
Atherosclerosis	DISMN9J3	Strong	Genetic Variation	[2]
Classic Hodgkin lymphoma	DISV1LU6	Strong	Genetic Variation	[3]
Myocardial infarction	DIS655KI	Strong	Genetic Variation	[4]
Obesity	DIS47Y1K	Strong	Biomarker	[5]
Respiratory failure	DISVMYJO	Strong	Biomarker	[6]
Schizophrenia	DISSRV2N	Strong	Altered Expression	[7]
Stroke	DISX6UHX	Strong	Biomarker	[8]
Urinary tract infection	DISMT6UV	Strong	Biomarker	[9]
Nervous system disease	DISJ7GGT	moderate	Biomarker	[10]
Tuberous sclerosis	DISEMUGZ	moderate	Biomarker	[10]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Probable E3 ubiquitin-protein ligase MARCHF10 (MARCHF10).	[11]

References

• [1] Body surface area and glucose tolerance - The smaller the person, the greater the 2-hour plasma glucose.Diabetes Res Clin Pract. 2019 Nov;157:107877. doi: 10.1016/j.diabres.2019.107877. Epub 2019 Oct 14.
• [2] Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study.JAMA. 2007 Apr 11;297(14):1551-61. doi: 10.1001/jama.297.14.1551.
• [3] Intensive treatment strategies in advanced-stage Hodgkin's lymphoma (HD9 and HD12): analysis of long-term survival in two randomised trials.Lancet Haematol. 2018 Oct;5(10):e462-e473. doi: 10.1016/S2352-3026(18)30140-6.
• [4] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.Atherosclerosis. 2011 Mar;215(1):145-52. doi: 10.1016/j.atherosclerosis.2010.12.005. Epub 2010 Dec 15.
• [5] Science-based solutions to obesity: what are the roles of academia, government, industry, and health care?.Am J Clin Nutr. 2005 Jul;82(1 Suppl):207S-210S. doi: 10.1093/ajcn/82.1.207S.
• [6] Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial.JAMA. 2017 Aug 22;318(8):731-740. doi: 10.1001/jama.2017.10569.
• [7] Psychological interventions for post-traumatic stress disorder (PTSD) in people with severe mental illness.Cochrane Database Syst Rev. 2017 Jan 24;1(1):CD011464. doi: 10.1002/14651858.CD011464.pub2.
• [8] Burden, clinical outcomes and predictors of time to in hospital mortality among adult patients admitted to stroke unit of Jimma university medical center: a prospective cohort study.BMC Neurol. 2019 Aug 30;19(1):213. doi: 10.1186/s12883-019-1439-7.
• [9] Prevalence and predictive factors of urinary tract infection among patients with stroke: A meta-analysis.Am J Infect Control. 2018 Apr;46(4):402-409. doi: 10.1016/j.ajic.2017.10.001. Epub 2017 Nov 16.
• [10] Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.Pediatr Neurol. 2016 Jul;60:1-12. doi: 10.1016/j.pediatrneurol.2016.03.015. Epub 2016 Apr 2.
• [11] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.