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Amlodipine FDA Label
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Atorvastatin FDA Label
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6380).
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Clinical pipeline report, company report or official report of Daiichi Sankyo.
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Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
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Pravastatin FDA Label
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Ramipril FDA Label
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Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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Rosuvastatin FDA Label
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Simvastatin FDA Label
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Telmisartan FDA Label
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7307).
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Vorapaxar FDA Label
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021112)
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ClinicalTrials.gov (NCT02374567) Pharmacovigilance in Gerontopsychiatric Patients. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00893867) Efficacy and Safety Study of DP-b99 in Treating Acute Ischemic Stroke. U.S. National Institutes of Health.
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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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ClinicalTrials.gov (NCT00229177) Study of ONO-2506 in Patients With Acute Ischemic Stroke. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00791063) 18F ML-10 for Early Detection of Response of Brain Metastases to WBRT. U.S. National Institutes of Health.
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Clinical pipeline report, company report or official report of Baxter Healthcare.
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ClinicalTrials.gov (NCT01808261) POC in Patients With Ischaemic Stroke. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00728182) Evaluating Neuroprotection in Aneurysm Coiling Therapy. U.S. National Institutes of Health.
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Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg. 2005 Jul;103(1):38-45.
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ClinicalTrials.gov (NCT00663416) REGENESIS (CA): A Study of NTx 265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients. U.S. National Institutes of Health.
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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021318)
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Clinical pipeline report, company report or official report of Astrocyte Pharmaceuticals
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ClinicalTrials.gov (NCT00827190) Study Evaluating Single Ascending Doses Of ILS-920. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015611)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037017)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027238)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003726)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032092)
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Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40.
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TREM1 Blockade: Killing Two Birds with One Stone.Trends Immunol. 2019 Sep;40(9):781-783. doi: 10.1016/j.it.2019.07.008. Epub 2019 Aug 20.
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Inactivation of endothelial adenosine A(2A) receptors protects mice from cerebral ischaemia-induced brain injury.Br J Pharmacol. 2019 Jul;176(13):2250-2263. doi: 10.1111/bph.14673. Epub 2019 May 21.
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Revalidation of the RACE scale after its regional implementation in Catalonia: a triage tool for large vessel occlusion.J Neurointerv Surg. 2019 Aug;11(8):751-756. doi: 10.1136/neurintsurg-2018-014519. Epub 2018 Dec 22.
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Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion.Sci Rep. 2019 Feb 28;9(1):3154. doi: 10.1038/s41598-019-39102-8.
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Association study of genetic variants of the ANGPTL3 gene and susceptibility to ischemic stroke.Neuropsychiatr Dis Treat. 2019 Oct 24;15:3015-3020. doi: 10.2147/NDT.S215387. eCollection 2019.
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Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood-Brain Barrier Alterations after Cerebral Photothrombosis in Rats.Int J Mol Sci. 2019 Aug 19;20(16):4036. doi: 10.3390/ijms20164036.
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Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation.Circulation. 2019 Jul 23;140(4):319-335. doi: 10.1161/CIRCULATIONAHA.118.039345. Epub 2019 Jun 3.
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Increase of aquaporin 9 expression in astrocytes participates in astrogliosis.J Neurosci Res. 2018 Feb;96(2):194-206. doi: 10.1002/jnr.24061. Epub 2017 Apr 17.
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Immunoluminometric assay for copeptin measurement in cerebrospinal fluid: Technical aspects and pilot study.Clin Chim Acta. 2019 Mar;490:181-185. doi: 10.1016/j.cca.2018.09.005. Epub 2018 Sep 6.
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C3a Receptor Inhibition Protects Brain Endothelial Cells Against Oxygen-glucose Deprivation/Reperfusion.Exp Neurobiol. 2019 Apr;28(2):216-228. doi: 10.5607/en.2019.28.2.216. Epub 2019 Apr 30.
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Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury.Neural Plast. 2019 Nov 14;2019:1071036. doi: 10.1155/2019/1071036. eCollection 2019.
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The calpain family and human disease.Trends Mol Med. 2001 Aug;7(8):355-62. doi: 10.1016/s1471-4914(01)02049-4.
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Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.J Neurosci Res. 2018 Mar;96(3):391-406. doi: 10.1002/jnr.24153. Epub 2017 Nov 29.
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CBS promoter hypermethylation increases the risk of hypertension and stroke.Clinics (Sao Paulo). 2019 Mar 21;74:e630. doi: 10.6061/clinics/2019/e630.
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Impact of Tag Single Nucleotide Polymorphisms (SNPs) in CCL11 Gene on Risk of Subtypes of Ischemic Stroke in Xinjiang Han Populations.Med Sci Monit. 2017 Sep 5;23:4291-4298. doi: 10.12659/msm.905942.
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CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke.J Neuroinflammation. 2019 Feb 18;16(1):40. doi: 10.1186/s12974-019-1426-3.
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Sevoflurane provides better haemodynamic stability than propofol during right ventricular ischaemia-reperfusion.Interact Cardiovasc Thorac Surg. 2020 Jan 1;30(1):129-135. doi: 10.1093/icvts/ivz235.
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The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke.Aging Dis. 2019 Oct 1;10(5):1140-1145. doi: 10.14336/AD.2018.1225. eCollection 2019 Oct.
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Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein.Circulation. 2009 Mar 24;119(11):1501-9. doi: 10.1161/CIRCULATIONAHA.108.833327. Epub 2009 Mar 9.
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Adaption and validation of the Mississippi Aphasia Screening Test to Estonian speakers with aphasia.Brain Behav. 2019 Jan;9(1):e01188. doi: 10.1002/brb3.1188. Epub 2018 Dec 19.
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L-NBP, a multiple growth factor activator, attenuates ischemic neuronal impairments possibly through promoting neuritogenesis.Neurochem Int. 2019 Mar;124:94-105. doi: 10.1016/j.neuint.2019.01.002. Epub 2019 Jan 7.
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A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio.Hum Mol Genet. 2019 Dec 15;28(24):4197-4207. doi: 10.1093/hmg/ddz243.
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TollLike receptor 4 promotes the phosphorylation of CRMP2 via the activation of Rhokinase in MCAO rats.Mol Med Rep. 2018 Jul;18(1):342-348. doi: 10.3892/mmr.2018.8968. Epub 2018 May 3.
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Genome-wide meta-analysis identifies 3 novel loci associated with stroke.Ann Neurol. 2018 Dec;84(6):934-939. doi: 10.1002/ana.25369. Epub 2018 Nov 30.
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Reduced Hemoglobin Levels Combined with an Increased Plasma Concentration of Vasoconstrictive endothelin-1 are Strongly Associated with Poor Outcome During Acute Ischemic Stroke.Curr Neurovasc Res. 2018;15(3):193-203. doi: 10.2174/1567202615666180726101531.
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Environmental enrichment during the chronic phase after experimental stroke promotes functional recovery without synergistic effects of EphA4 targeted therapy.Hum Mol Genet. 2020 Mar 13;29(4):605-617. doi: 10.1093/hmg/ddz288.
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F13A1 Gene Variant (V34L) and Residual Circulating FXIIIA Levels Predict Short- and Long-Term Mortality in Acute Myocardial Infarction after Coronary Angioplasty.Int J Mol Sci. 2018 Sep 14;19(9):2766. doi: 10.3390/ijms19092766.
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Urinary liver-type fatty acid binding protein is an independent predictor of stroke and mortality in individuals with type 1 diabetes.Diabetologia. 2017 Sep;60(9):1782-1790. doi: 10.1007/s00125-017-4328-x. Epub 2017 Jun 10.
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Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation.Brain Behav Immun. 2019 Nov;82:406-421. doi: 10.1016/j.bbi.2019.09.009. Epub 2019 Sep 13.
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Cardiovascular disease risk factors, tract-based structural connectomics, and cognition in older adults.Neuroimage. 2019 Aug 1;196:152-160. doi: 10.1016/j.neuroimage.2019.04.024. Epub 2019 Apr 10.
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PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial.Stroke. 2017 Apr;48(4):977-982. doi: 10.1161/STROKEAHA.116.015957. Epub 2017 Mar 13.
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Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular remodeling via promoting the proliferation of basilar smooth muscle cells in hypertension.Biochem Biophys Res Commun. 2019 Oct 15;518(2):278-285. doi: 10.1016/j.bbrc.2019.08.047. Epub 2019 Aug 13.
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Targeting Platelet GPVI Plus rt-PA Administration but Not 21-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice.Int J Mol Sci. 2019 Apr 24;20(8):2019. doi: 10.3390/ijms20082019.
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Discovery and development of NA-1 for the treatment of acute ischemic stroke.Acta Pharmacol Sin. 2018 May;39(5):661-668. doi: 10.1038/aps.2018.5. Epub 2018 Mar 22.
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Expression of Class IHistone Deacetylases in Ipsilateral and Contralateral Hemispheres after the Focal Photothrombotic Infarction in the Mouse Brain.Transl Stroke Res. 2018 Oct;9(5):471-483. doi: 10.1007/s12975-017-0595-6. Epub 2017 Dec 7.
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Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia.J Clin Biochem Nutr. 2018 Jul;63(1):70-79. doi: 10.3164/jcbn.17-136. Epub 2018 Apr 11.
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HSPA12B promotes functional recovery after ischaemic stroke through an eNOS-dependent mechanism.J Cell Mol Med. 2018 Apr;22(4):2252-2262. doi: 10.1111/jcmm.13507. Epub 2018 Feb 7.
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Sputum interleukin-25 correlates with asthma severity: a preliminary study.Postepy Dermatol Alergol. 2018 Oct;35(5):462-469. doi: 10.5114/ada.2017.71428. Epub 2018 Jul 19.
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Biomarkers of immune capacity, infection and inflammation are associated with poor outcome and mortality after stroke - the PREDICT study.BMC Neurol. 2019 Jul 3;19(1):148. doi: 10.1186/s12883-019-1375-6.
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Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats.Brain Res. 2019 Mar 15;1707:62-73. doi: 10.1016/j.brainres.2018.11.017. Epub 2018 Nov 13.
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Association between lymphotoxin alpha (-252 A/G and -804 C/A) gene polymorphisms and risk of stroke in North Indian population: a hospital-based case-control study.Int J Neurosci. 2016 Dec;126(12):1127-35. doi: 10.3109/00207454.2015.1134527. Epub 2016 Jan 20.
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Blockage of Central Sphingosine-1-phosphate Receptor does not Abolish the Protective Effect of FTY720 in Early Brain Injury after Experimental Subarachnoid Hemorrhage.Curr Drug Deliv. 2017 Sep 6;14(6):861-866. doi: 10.2174/1567201813666160907094401.
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Simultaneous screening and isolation of activated constituents from Puerariae Flos by ultrafiltration with liquid chromatography and mass spectrometry combined with high-speed counter-current chromatography.J Sep Sci. 2018 Dec;41(24):4458-4468. doi: 10.1002/jssc.201800691.
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Monoacylglycerol Lipase Inhibitor is Safe when Combined with Delayed r-tPA Administration in Treatment of Stroke.Inflammation. 2018 Dec;41(6):2052-2059. doi: 10.1007/s10753-018-0848-x.
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Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke.FASEB J. 2018 May;32(5):2381-2394. doi: 10.1096/fj.201700746R. Epub 2017 Dec 21.
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Brain-derived neurotrophic factor levels in pediatric sickle cell disease.Pediatr Blood Cancer. 2020 Feb;67(2):e28076. doi: 10.1002/pbc.28076. Epub 2019 Nov 17.
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Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort.Eur J Intern Med. 2013 Jan;24(1):80-2. doi: 10.1016/j.ejim.2012.09.002. Epub 2012 Sep 18.
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Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline.BMJ. 2018 Dec 18;363:k5130. doi: 10.1136/bmj.k5130.
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Increased Serum Netrin-1 Is Associated With Improved Prognosis of Ischemic Stroke.Stroke. 2019 Apr;50(4):845-852. doi: 10.1161/STROKEAHA.118.024631.
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High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke.J Am Heart Assoc. 2019 Feb 19;8(4):e009874. doi: 10.1161/JAHA.118.009874.
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The importance of selected markers of inflammation and blood-brain barrier damage for short-term ischemic stroke prognosis.J Physiol Pharmacol. 2019 Apr;70(2). doi: 10.26402/jpp.2019.2.04. Epub 2019 Jul 22.
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TAT-PEP Enhanced Neurobehavioral Functional Recovery by Facilitating Axonal Regeneration and Corticospinal Tract Projection After Stroke.Mol Neurobiol. 2018 Jan;55(1):652-667. doi: 10.1007/s12035-016-0301-9. Epub 2016 Dec 16.
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Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke.Front Neurosci. 2018 Feb 20;12:89. doi: 10.3389/fnins.2018.00089. eCollection 2018.
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A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke models.J Pharmacol Sci. 2019 Nov;141(3):119-126. doi: 10.1016/j.jphs.2019.09.012. Epub 2019 Oct 15.
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Constraint-induced movement therapy enhances angiogenesis and neurogenesis after cerebral ischemia/reperfusion.Neural Regen Res. 2019 Oct;14(10):1743-1754. doi: 10.4103/1673-5374.257528.
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The S100B story: from biomarker to active factor in neural injury.J Neurochem. 2019 Jan;148(2):168-187. doi: 10.1111/jnc.14574. Epub 2018 Nov 12.
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Sphingosine-1-Phosphate Receptor 1 Activation Enhances Leptomeningeal Collateral Development and Improves Outcome after Stroke in Mice.J Stroke Cerebrovasc Dis. 2018 May;27(5):1237-1251. doi: 10.1016/j.jstrokecerebrovasdis.2017.11.040. Epub 2018 Jan 11.
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Sema4D/PlexinB1 inhibition ameliorates blood-brain barrier damage and improves outcome after stroke in rats.FASEB J. 2018 Apr;32(4):2181-2196. doi: 10.1096/fj.201700786RR. Epub 2018 Jan 5.
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High-throughput profiling of the circulating proteome suggests sexually dimorphic corticosteroid signaling following ischemic stroke.Physiol Genomics. 2018 Oct 1;50(10):876-883. doi: 10.1152/physiolgenomics.00058.2018. Epub 2018 Jul 20.
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Combined Biomarkers Composed of Environment and Genetic Factors in Stroke.Biosci Trends. 2018 Sep 19;12(4):360-368. doi: 10.5582/bst.2018.01150. Epub 2018 Aug 29.
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Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.J Neurosci. 2015 May 13;35(19):7332-48. doi: 10.1523/JNEUROSCI.2174-14.2015.
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Neuronal Transmembrane Chloride Transport Has a Time-Dependent Influence on Survival of Hippocampal Cultures to Oxygen-Glucose Deprivation.Brain Sci. 2019 Dec 6;9(12):360. doi: 10.3390/brainsci9120360.
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Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine.Front Neurol. 2019 Sep 27;10:1041. doi: 10.3389/fneur.2019.01041. eCollection 2019.
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Wake-up stroke: thrombolysis reduces ischemic lesion volume and neurological deficit.J Neurol. 2020 Mar;267(3):666-673. doi: 10.1007/s00415-019-09603-7. Epub 2019 Nov 12.
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Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the Rat Hippocampus After Heat Stroke.Shock. 2019 Jun;51(6):780-786. doi: 10.1097/SHK.0000000000001182.
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Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis.Diabetes Obes Metab. 2019 May;21(5):1237-1250. doi: 10.1111/dom.13648. Epub 2019 Mar 4.
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GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice.J Cereb Blood Flow Metab. 2019 Jan;39(1):74-88. doi: 10.1177/0271678X17744123. Epub 2017 Nov 21.
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Medicare claims can identify post-stroke epilepsy.Epilepsy Res. 2019 Mar;151:40-47. doi: 10.1016/j.eplepsyres.2019.02.002. Epub 2019 Feb 8.
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Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke.J Cereb Blood Flow Metab. 2019 Oct;39(10):1906-1918. doi: 10.1177/0271678X18817282. Epub 2018 Dec 7.
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Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX.Mol Pharmacol. 2020 Feb;97(2):102-111. doi: 10.1124/mol.119.117549. Epub 2019 Nov 26.
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Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4643-4650. doi: 10.1073/pnas.1821282116. Epub 2019 Feb 13.
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Association of ATP-Binding Cassette Transporter G1 Polymorphisms with Risk of Ischemic Stroke in the Chinese Han Population.J Stroke Cerebrovasc Dis. 2015 Jun;24(6):1397-404. doi: 10.1016/j.jstrokecerebrovasdis.2015.02.024. Epub 2015 Apr 15.
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Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study.Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1192-H1201. doi: 10.1152/ajpheart.00446.2018. Epub 2019 Mar 1.
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Genetic Variants of RAMP2 and CLR are Associated with Stroke.J Atheroscler Thromb. 2017 Dec 1;24(12):1267-1281. doi: 10.5551/jat.41517. Epub 2017 Sep 14.
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