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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023304)
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ClinicalTrials.gov (NCT01311518) A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial Infarction. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021706)
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ClinicalTrials.gov (NCT00144014) Safety and Efficacy Study in Acute Ischaemic Stroke. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025803)
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ClinicalTrials.gov (NCT00886353) Safety and Tolerability Study of APN01 (Recombinant Human Angiotensin Converting Enzyme 2). U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027040)
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ClinicalTrials.gov (NCT00984113) Pharmacokinetics of Elinogrel in Healthy Volunteers and Patients With Mild, Moderate, and Severe Renal Impairment. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019945)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001565)
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6548).
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005012)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004026)
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Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart fail... Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015478)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007938)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004614)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004736)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010067)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010403)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004615)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025735)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004786)
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The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 948).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2393).
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800042366)
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Myocardial infarction in a 36-year-old man with combined ABCA1 and APOA-1 deficiency.J Clin Lipidol. 2015 May-Jun;9(3):396-9. doi: 10.1016/j.jacl.2015.01.006. Epub 2015 Jan 28.
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The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats.Biomed Pharmacother. 2018 Nov;107:212-218. doi: 10.1016/j.biopha.2018.07.170. Epub 2018 Aug 6.
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Haplodeficiency of activin receptor-like kinase 4 alleviates myocardial infarction-induced cardiac fibrosis and preserves cardiac function.J Mol Cell Cardiol. 2017 Apr;105:1-11. doi: 10.1016/j.yjmcc.2017.02.002. Epub 2017 Feb 16.
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Intermedin 1-53 Inhibits Myocardial Fibrosis in Rats by Down-Regulating Transforming Growth Factor-.Med Sci Monit. 2017 Jan 9;23:121-128. doi: 10.12659/msm.898522.
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Role of adenosine in delayed preconditioning of myocardium.Cardiovasc Res. 2002 Aug 15;55(3):483-94. doi: 10.1016/s0008-6363(02)00280-8.
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A(3) adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells.J Mol Cell Cardiol. 2010 Aug;49(2):280-6. doi: 10.1016/j.yjmcc.2010.01.018. Epub 2010 Feb 2.
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Protease-activated receptor 2 protects against myocardial ischemia-reperfusion injury through the lipoxygenase pathway and TRPV1 channels.Exp Ther Med. 2019 Nov;18(5):3636-3642. doi: 10.3892/etm.2019.7987. Epub 2019 Sep 9.
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Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4.J Proteomics. 2019 Sep 30;208:103486. doi: 10.1016/j.jprot.2019.103486. Epub 2019 Aug 19.
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ANGPTL3 possibly promotes cardiac angiogenesis through improving proangiogenic ability of endothelial progenitor cells after myocardial infarction.Lipids Health Dis. 2018 Aug 7;17(1):184. doi: 10.1186/s12944-018-0835-0.
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Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype.Cardiovasc Diabetol. 2019 Mar 22;18(1):39. doi: 10.1186/s12933-019-0829-x.
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APOL1 Genotype, Kidney and Cardiovascular Disease, and Death in Older Adults.Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):398-403. doi: 10.1161/ATVBAHA.115.305970. Epub 2015 Dec 3.
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Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway.Heart Vessels. 2019 Dec;34(12):2041-2051. doi: 10.1007/s00380-019-01452-8. Epub 2019 Jun 19.
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Revised Cardiac Risk Index as a Predictor for Myocardial Infarction and Cardiac Arrest Following Posterior Lumbar Decompression.Spine (Phila Pa 1976). 2019 Feb 1;44(3):E187-E193. doi: 10.1097/BRS.0000000000002783.
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Autophagy signaling in skeletal muscle of infarcted rats.PLoS One. 2014 Jan 10;9(1):e85820. doi: 10.1371/journal.pone.0085820. eCollection 2014.
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DRm217 attenuates myocardial ischemia-reperfusion injury via stabilizing plasma membrane Na(+)-K(+)-ATPase, inhibiting Na(+)-K(+)-ATPase/ROS pathway and activating PI3K/Akt and ERK1/2.Toxicol Appl Pharmacol. 2018 Jun 15;349:62-71. doi: 10.1016/j.taap.2018.04.030. Epub 2018 Apr 25.
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A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.J Mol Cell Cardiol. 2018 Jan;114:72-82. doi: 10.1016/j.yjmcc.2017.11.003. Epub 2017 Nov 7.
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Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction.J Mol Cell Cardiol. 2004 Apr;36(4):547-59. doi: 10.1016/j.yjmcc.2004.02.002.
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CD177-mediated nanoparticle targeting of human and mouse neutrophils.PLoS One. 2018 Jul 10;13(7):e0200444. doi: 10.1371/journal.pone.0200444. eCollection 2018.
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Involvement of lncR-30245 in Myocardial Infarction-Induced Cardiac Fibrosis Through Peroxisome Proliferator-Activated Receptor--Mediated Connective Tissue Growth Factor Signalling Pathway.Can J Cardiol. 2019 Apr;35(4):480-489. doi: 10.1016/j.cjca.2019.02.005. Epub 2019 Feb 16.
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Interventional effect of valsartan on expression of inducible cAMP early repressor and phosphodiesterase 3A in rats after myocardial infarction.Eur J Pharmacol. 2009 Jan 14;602(2-3):348-54. doi: 10.1016/j.ejphar.2008.11.002. Epub 2008 Nov 9.
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Cathepsin D improves the prediction of undetected diabetes in patients with myocardial infarction.Ups J Med Sci. 2019 Aug;124(3):187-192. doi: 10.1080/03009734.2019.1650141. Epub 2019 Aug 20.
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Mast cell derived carboxypeptidase A3 is decreased among patients with advanced coronary artery disease.Cardiol J. 2019;26(6):680-686. doi: 10.5603/CJ.a2018.0018. Epub 2018 Mar 7.
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Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction.J Mol Cell Cardiol. 2019 Feb;127:44-56. doi: 10.1016/j.yjmcc.2018.11.010. Epub 2018 Nov 19.
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Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis.Antioxidants (Basel). 2019 Jan 10;8(1):18. doi: 10.3390/antiox8010018.
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Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.Cardiovasc Res. 2009 Feb 15;81(3):574-81. doi: 10.1093/cvr/cvn222. Epub 2008 Aug 8.
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Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases.Am J Clin Nutr. 2019 Mar 1;109(3):509-516. doi: 10.1093/ajcn/nqy297.
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Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty.Circulation. 2002 May 28;105(21):2556-61. doi: 10.1161/01.cir.0000016722.37138.f2.
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Versican is induced in infiltrating monocytes in myocardial infarction.Mol Cell Biochem. 2005 Dec;280(1-2):47-56. doi: 10.1007/s11010-005-8051-4.
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Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction.Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1105-12. doi: 10.1152/ajpheart.00927.2006. Epub 2006 Oct 27.
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Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice.Circ Res. 2019 Apr 26;124(9):1323-1336. doi: 10.1161/CIRCRESAHA.118.314569.
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Downregulated microRNA-224 aggravates vulnerable atherosclerotic plaques and vascular remodeling in acute coronary syndrome through activation of the TGF-/Smad pathway.J Cell Physiol. 2019 Mar;234(3):2537-2551. doi: 10.1002/jcp.26945. Epub 2018 Oct 14.
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Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo.Life Sci. 1999;65(16):1671-83. doi: 10.1016/s0024-3205(99)00416-6.
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Elastase-2, an angiotensin II-generating enzyme, contributes to increased angiotensin II in resistance arteries of mice with myocardial infarction.Br J Pharmacol. 2017 May;174(10):1104-1115. doi: 10.1111/bph.13755. Epub 2017 Apr 5.
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A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury.Eur Heart J. 2018 Jan 7;39(2):111-116. doi: 10.1093/eurheartj/ehx218.
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Regional expression of the hypoxia-inducible factor (HIF) system and association with cardiomyocyte cell cycle re-entry after myocardial infarction in rats.Heart Vessels. 2008 May;23(3):193-200. doi: 10.1007/s00380-007-1029-2. Epub 2008 May 17.
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Protective effects of erythropoietin on myocardial infarction in rats: the role of AMP-activated protein kinase signaling pathway.Am J Med Sci. 2011 Aug;342(2):153-9. doi: 10.1097/MAJ.0b013e318210041d.
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Genetic determinants of activity and antigen levels of contact system factors.J Thromb Haemost. 2019 Jan;17(1):157-168. doi: 10.1111/jth.14307. Epub 2018 Nov 2.
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Cytokine-loaded PLGA and PEG-PLGA microparticles showed similar heart regeneration in a rat myocardial infarction model.Int J Pharm. 2017 May 25;523(2):531-533. doi: 10.1016/j.ijpharm.2016.11.022. Epub 2016 Nov 9.
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Inhibition of FPR2 impaired leukocytes recruitment and elicited non-resolving inflammation in acute heart failure.Pharmacol Res. 2019 Aug;146:104295. doi: 10.1016/j.phrs.2019.104295. Epub 2019 Jun 16.
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Screening for the Biomarkers Associated with Myocardial Infarction by Bioinformatics Analysis.J Comput Biol. 2020 May;27(5):779-785. doi: 10.1089/cmb.2019.0180. Epub 2019 Sep 9.
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Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction.Exp Toxicol Pathol. 2011 Sep;63(6):535-40. doi: 10.1016/j.etp.2010.04.004. Epub 2010 May 11.
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Sympathetic nervous remodeling is induced in the intermediolateral nucleus after myocardial infarction - Role of BDNF-TrkB axis.Neurosci Lett. 2018 Oct 15;685:114-123. doi: 10.1016/j.neulet.2018.08.004. Epub 2018 Aug 16.
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Role of gamma-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts.Am J Physiol Cell Physiol. 2009 Aug;297(2):C253-62. doi: 10.1152/ajpcell.00634.2008. Epub 2009 May 6.
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Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure.Biomed Pharmacother. 2018 Apr;100:156-167. doi: 10.1016/j.biopha.2018.02.013. Epub 2018 Feb 8.
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GPR 30 reduces myocardial infarct area and fibrosis in female ovariectomized mice by activating the PI3K/AKT pathway.Life Sci. 2019 Jun 1;226:22-32. doi: 10.1016/j.lfs.2019.03.049. Epub 2019 Mar 21.
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Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion.EBioMedicine. 2019 Oct;48:605-618. doi: 10.1016/j.ebiom.2019.09.019. Epub 2019 Oct 5.
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Oleuropein offers cardioprotection in rats with acute myocardial infarction.Cardiovasc Toxicol. 2015 Jan;15(1):61-8. doi: 10.1007/s12012-014-9271-1.
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The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction.Hum Genomics. 2019 Jan 24;13(1):5. doi: 10.1186/s40246-018-0189-8.
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Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.EBioMedicine. 2019 Jan;39:59-68. doi: 10.1016/j.ebiom.2018.11.056. Epub 2018 Dec 5.
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The value of endoplasmic reticulum stress markers (GRP78 and CHOP) in the diagnosis of acute mesenteric ischemia.Am J Emerg Med. 2019 Apr;37(4):596-602. doi: 10.1016/j.ajem.2018.06.033. Epub 2018 Jun 19.
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Sustained release of bioactive IGF-1 from a silk fibroin microsphere-based injectable alginate hydrogel for the treatment of myocardial infarction.J Mater Chem B. 2020 Jan 14;8(2):308-315. doi: 10.1039/c9tb01971e. Epub 2019 Dec 6.
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Interleukin-10 Deficiency Alters Endothelial Progenitor Cell-Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment.Circ Res. 2020 Jan 31;126(3):315-329. doi: 10.1161/CIRCRESAHA.119.315829. Epub 2019 Dec 9.
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Expression of adhesion molecules on granulocytes and monocytes following myocardial infarction in rats drinking white wine.PLoS One. 2018 May 10;13(5):e0196842. doi: 10.1371/journal.pone.0196842. eCollection 2018.
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Clonal hematopoiesis of indeterminate potential-associated mutations and risk of comorbidities in patients with myelodysplastic syndrome.Cancer. 2019 Jul 1;125(13):2233-2241. doi: 10.1002/cncr.32056. Epub 2019 Mar 12.
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Methylation-dependent transcriptional repression of RUNX3 by KCNQ1OT1 regulates mouse cardiac microvascular endothelial cell viability and inflammatory response following myocardial infarction.FASEB J. 2019 Dec;33(12):13145-13160. doi: 10.1096/fj.201900310R. Epub 2019 Oct 18.
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LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodelling by regulating KDM3A.J Cell Mol Med. 2020 Jan;24(1):1099-1115. doi: 10.1111/jcmm.14846. Epub 2019 Nov 21.
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miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4.Stem Cell Res Ther. 2018 May 30;9(1):151. doi: 10.1186/s13287-018-0895-0.
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Interval exercise training increases LIF expression and prevents myocardial infarction-induced skeletal muscle atrophy in rats.Life Sci. 2018 Jan 15;193:77-86. doi: 10.1016/j.lfs.2017.12.009. Epub 2017 Dec 7.
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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.Lancet. 2012 Aug 11;380(9841):572-80. doi: 10.1016/S0140-6736(12)60312-2. Epub 2012 May 17.
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An apoptosis signal-regulating kinase 1 inhibitor reduces cardiomyocyte apoptosis and infarct size in a rat ischemia-reperfusion model.J Cardiovasc Pharmacol. 2012 Sep;60(3):276-82. doi: 10.1097/FJC.0b013e31825ea0fa.
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Effect of ulinastatin on myocardial ischemia-reperfusion injury through JNK and P38 MAPK signaling pathways.Eur Rev Med Pharmacol Sci. 2019 Oct;23(19):8658-8664. doi: 10.26355/eurrev_201910_19183.
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Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure.Sci Rep. 2019 Apr 8;9(1):5791. doi: 10.1038/s41598-019-42113-0.
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