General Information of Disease (ID: DISJ7GGT)

Disease Name Nervous system disease
Synonyms
neurologic disease; disorder of nervous system; nervous system disease; disease of nervous system; neurological disorder; neurological disease; nervous system disorder; disease or disorder of nervous system; neurologic disorder; nervous system disease or disorder
Disease Class 8A00-8E7Z: Nervous system disease
Definition
A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves.|'psychiatric disorder' is not classified as a 'nervous system disorder' in Mondo (though it is often as such): the hallmarks of psychiatric disorders are based in behavior and emotional state, and the relation with nervous system malfunction or damage is not always clearly determined.
Disease Hierarchy
DISH7H5I: Human disease
DISJ7GGT: Nervous system disease
ICD Code
ICD-11
ICD-11: 8A00-8E7Z
ICD-10
ICD-10: G64, G90.0
Expand ICD-9
356.0,356.8
Disease Identifiers
MONDO ID
MONDO_0005071
MESH ID
D009422
UMLS CUI
C0027765
MedGen ID
14336
SNOMED CT ID
118940003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Vivaglobin DMAXCK4 Approved NA [1]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
SB-509 DMQG9OI Phase 2 NA [2]
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This Disease is Treated as An Indication in 1 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
Tihotungstate derivative 1 DM5UI73 Patented Small molecular drug [3]
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This Disease is Treated as An Indication in 2 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CM-2359 DMJ3BUQ Terminated NA [4]
CNS-1531 DMZ5N2I Terminated NA [5]
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This Disease is Treated as An Indication in 2 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BC-PN-02 DMW9GCV Investigative NA [6]
SUN-44 DMHSMVR Investigative NA [6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 219 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCB1 TT3OT40 Limited Biomarker [7]
ABCC8 TTP835K Limited Biomarker [8]
ALDH3A2 TTB6UM0 Limited Biomarker [9]
ASPA TT6TLZP Limited Biomarker [10]
ATF3 TTCE793 Limited Biomarker [11]
ATP1A2 TT5B6HJ Limited Genetic Variation [12]
ATP7B TTOPO51 Limited Genetic Variation [13]
BDNF TTSMLOH Limited Biomarker [14]
C9orf72 TTA4SHR Limited Biomarker [15]
CACNA1D TT7RGTM Limited Genetic Variation [16]
CACNA1F TTJ0SO4 Limited Genetic Variation [17]
CAPN2 TTG5QB7 Limited Biomarker [18]
CASP3 TTPF2QI Limited Biomarker [19]
CASP9 TTB6T7O Limited Biomarker [20]
CD46 TTMS7DF Limited Biomarker [21]
CDK5 TTL4Q97 Limited Biomarker [22]
CDK5R1 TTBYM6V Limited Altered Expression [23]
CHRNA4 TT4H1MQ Limited Biomarker [24]
CLN3 TTORF9W Limited Genetic Variation [25]
CNR2 TTMSFAW Limited Biomarker [26]
COMT TTKWFB8 Limited Biomarker [27]
CSF3 TT5TQ2W Limited Biomarker [28]
DHFR TTYZVDJ Limited Biomarker [29]
DNM1 TTE3JW9 Limited Genetic Variation [30]
DPYSL2 TTZCW3T Limited Genetic Variation [31]
DRD4 TTE0A2F Limited Biomarker [32]
DYRK1A TTSBVFO Limited Biomarker [33]
EHMT1 TTOFXD7 Limited Biomarker [34]
EIF2AK2 TTXEZJ4 Limited Biomarker [35]
EPHA4 TTG84D3 Limited Biomarker [36]
FOS TTOM5AU Limited Biomarker [37]
FTO TTFW3BT Limited Altered Expression [38]
GABRA3 TT37EDJ Limited Biomarker [39]
GAN TT6WNG2 Limited Genetic Variation [40]
GAP43 TTSGLN5 Limited Biomarker [41]
GCH1 TTLSWP6 Limited Biomarker [42]
GLUL TTURQ2G Limited Biomarker [43]
GNAO1 TTAXD8Z Limited Biomarker [44]
GRIA2 TTWM461 Limited Biomarker [45]
GRIA3 TT82EZV Limited Genetic Variation [39]
GRIK1 TT0MYE2 Limited Altered Expression [46]
GRIN2D TT5POTG Limited Altered Expression [46]
GRM2 TTXJ47W Limited Biomarker [47]
GRM5 TTHS256 Limited Biomarker [48]
GRPR TTC1MVT Limited Biomarker [49]
GUSB TTHS7CM Limited Biomarker [50]
HAX1 TT21BYA Limited Biomarker [51]
HDAC3 TT4YWTO Limited Biomarker [52]
HDAC6 TT5ZKDI Limited Biomarker [53]
HTR1A TTSQIFT Limited Biomarker [54]
HTR7 TTO9X1H Limited Biomarker [55]
IDUA TT0IUKX Limited Biomarker [56]
IL2RB TT9721Y Limited Biomarker [57]
ITPR1 TT5HWAT Limited Biomarker [58]
KCNC3 TTALSY9 Limited Genetic Variation [59]
KCNJ5 TTEO25X Limited Genetic Variation [16]
KCNQ2 TTPXI3S Limited Biomarker [24]
KIF5A TTCJPAH Limited Biomarker [60]
LRP2 TTPH1AJ Limited Biomarker [61]
MCOLN1 TT9XBVO Limited Genetic Variation [62]
MGLL TTZ963I Limited Biomarker [63]
MSMB TTYH1ZK Limited Biomarker [64]
NOD1 TTYSRXM Limited Biomarker [65]
NOTCH1 TTB1STW Limited Biomarker [66]
NQO2 TTJLP0R Limited Genetic Variation [67]
NR4A2 TT9HKN3 Limited Biomarker [68]
OGDH TTH8T6I Limited Biomarker [69]
PDXP TT9UYG4 Limited Altered Expression [70]
PNP TTMCF1Y Limited Genetic Variation [71]
PNPLA6 TTWAQU2 Limited Biomarker [72]
PSIP1 TTH9LDP Limited Biomarker [57]
PTN TTA9EJK Limited Altered Expression [73]
RNMT TTG45HY Limited Biomarker [74]
SCN1A TTANOZH Limited Altered Expression [75]
SIGMAR1 TT5TPI6 Limited Altered Expression [76]
SIRT2 TTLKF5M Limited Biomarker [77]
SIRT5 TTH0IOD Limited Genetic Variation [78]
SLC12A6 TT8DFHE Limited Biomarker [79]
SLC18A2 TTNZRI3 Limited Biomarker [37]
SLC19A3 TT9BTWM Limited Genetic Variation [80]
SLC6A3 TTVBI8W Limited Genetic Variation [81]
SLC7A5 TTPH2JB Limited Biomarker [82]
SNAP25 TTYQWA0 Limited Genetic Variation [83]
SORT1 TTRX9AV Limited Biomarker [84]
STK33 TTP34DQ Limited Altered Expression [85]
SV2A TTT3P91 Limited Biomarker [86]
TCF3 TTULOD8 Limited Biomarker [57]
TNF TTF8CQI Limited Biomarker [87]
TNFRSF14 TTWGTC1 Limited Biomarker [88]
TOP1 TTGTQHC Limited Biomarker [89]
TPH1 TTZSJHV Limited Biomarker [90]
TPP1 TTOVYPT Limited Genetic Variation [91]
TREM2 TTQRMSJ Limited Genetic Variation [92]
TRPM2 TTEBMN7 Limited Biomarker [93]
TSPO TTPTXIN Limited Genetic Variation [94]
TTR TTPOYU7 Limited Genetic Variation [95]
TYMS TTP1UKZ Limited Genetic Variation [96]
ULK1 TT4D7MJ Limited Biomarker [97]
USP14 TTVSYP9 Limited Genetic Variation [98]
XPA TTGT87E Limited Biomarker [99]
ZUP1 TTZC0KV Limited Genetic Variation [100]
ATXN3 TT6A17J Disputed Genetic Variation [101]
BACH1 TT2ME4S Disputed Biomarker [102]
CPE TTXPWO6 Disputed Genetic Variation [103]
DLG4 TT9PB26 Disputed Biomarker [104]
ENPP2 TTSCIM2 Disputed Biomarker [105]
GRM1 TTVBPDM Disputed Biomarker [106]
ITPR3 TTH1769 Disputed Biomarker [58]
LYZ TTAOZBW Disputed Biomarker [107]
MAG TT9XFON Disputed Biomarker [108]
PCSK2 TT46F0P Disputed Biomarker [109]
PDE7A TT1BC3A Disputed Biomarker [110]
SLC40A1 TT6Y1PG Disputed Biomarker [109]
TTK TTP7EGM Disputed Biomarker [56]
GCG TT6Y4PN moderate Biomarker [111]
PRNP TTY5F9C moderate Genetic Variation [112]
SLC1A2 TT2F078 moderate Biomarker [113]
TOR1A TTF85KW moderate Biomarker [114]
ABCC2 TTFLHJV Strong Biomarker [115]
ABCG2 TTIMJ02 Strong Biomarker [115]
ADCYAP1R1 TT5OREU Strong Altered Expression [116]
ADRB2 TTG8ZWP Strong Biomarker [117]
ALPL TTMR5UV Strong Altered Expression [118]
APP TTE4KHA Strong Biomarker [119]
CACNA1A TTX4QDJ Strong Genetic Variation [120]
CACNA2D2 TTU8P3M Strong Biomarker [121]
CAMKK1 TTGLQWZ Strong Biomarker [117]
CLCN2 TT30NW6 Strong Biomarker [122]
CRYBB1 TTDS503 Strong Biomarker [123]
CYP2C9 TTR40YJ Strong Biomarker [117]
DNM2 TTVRA5G Strong Biomarker [124]
DPYD TTZPS91 Strong Genetic Variation [125]
DRD2 TTEX248 Strong Genetic Variation [126]
GAD1 TTKGEP3 Strong Biomarker [127]
GAD2 TT7UY6K Strong Genetic Variation [128]
GBA TT1B5PU Strong Biomarker [129]
GLP1R TTVIMDE Strong Biomarker [130]
GLRA1 TTF45NW Strong Genetic Variation [131]
GPR35 TT254XD Strong Biomarker [132]
GRIN2B TTN9D8E Strong Biomarker [133]
HCRT TTU5HJP Strong Biomarker [44]
HSPB8 TTY0OJN Strong Biomarker [134]
HTT TTIWZ0O Strong Genetic Variation [135]
L1CAM TTC9D3K Strong Biomarker [136]
LAMC2 TTNS7H3 Strong Biomarker [137]
MANF TT56RYE Strong Biomarker [138]
MAOA TT3WG5C Strong Biomarker [139]
MAOB TTGP7BY Strong Biomarker [140]
MAPT TTS87KH Strong Biomarker [141]
MECP2 TTTAU9R Strong Genetic Variation [142]
MTHFR TTQWOU1 Strong Biomarker [115]
NCL TTK1V5Q Strong Genetic Variation [143]
NOS1 TTZUFI5 Strong Biomarker [144]
NPTX2 TTNJ5A6 Strong Biomarker [145]
NTF3 TTZHKV9 Strong Biomarker [146]
P2RX7 TT473XN Strong Biomarker [147]
PDE10A TTJW4LU Strong Biomarker [148]
PNKP TTHR3IE Strong Genetic Variation [149]
PSEN1 TTZ3S8C Strong Genetic Variation [150]
RGS4 TTGTKX9 Strong Biomarker [151]
SCN2A TTLJTUF Strong Genetic Variation [152]
SCT TTOBVIN Strong Biomarker [153]
SERPINE1 TTTO43N Strong Biomarker [117]
SLC10A2 TTPI1M5 Strong Biomarker [117]
SLC19A1 TT09I7D Strong Biomarker [115]
SLC1A1 TTG2A6F Strong Biomarker [154]
SLC1A3 TT8WRDA Strong Biomarker [155]
SLC2A1 TT79TKF Strong Biomarker [156]
SLC6A5 TTI0138 Strong Genetic Variation [157]
SLITRK6 TTTVEKI Strong Altered Expression [158]
SMPD1 TTJTM88 Strong Biomarker [159]
SNCA TT08OSU Strong Altered Expression [160]
TARDBP TT9RZ03 Strong Biomarker [161]
TDP1 TT64IHJ Strong Genetic Variation [162]
THBS1 TTKI0H1 Strong Biomarker [163]
UBE3A TTUZX6V Strong Biomarker [164]
ACHE TT1RS9F Definitive Biomarker [165]
ADAM10 TTVXEGU Definitive Biomarker [166]
AMOT TTI48OS Definitive Biomarker [167]
BCHE TT3MSAO Definitive Biomarker [168]
BST2 TT90BJT Definitive Biomarker [169]
CASP6 TTKW4ML Definitive Biomarker [170]
CSF1R TT7MRDV Definitive Biomarker [171]
FUS TTKGYZ9 Definitive Genetic Variation [172]
GABRG3 TTEX6LM Definitive Biomarker [173]
GFAP TTI6FFX Definitive Biomarker [174]
GRIN2A TTKJEMQ Definitive Altered Expression [175]
HCRTR2 TT9N02I Definitive Biomarker [44]
HLA-DQB2 TTL7VOU Definitive Biomarker [44]
IDS TTNY2AP Definitive Biomarker [176]
KMO TTIY56R Definitive Biomarker [177]
MAPK10 TT056SO Definitive Biomarker [178]
MOG TTQAFX5 Definitive Biomarker [179]
NDUFA13 TTRU1NG Definitive Biomarker [180]
NGF TTDN3LF Definitive Biomarker [181]
OPA1 TTTU49Q Definitive Genetic Variation [182]
P2RY6 TTNVSKA Definitive Biomarker [183]
PPT1 TTSQC14 Definitive Genetic Variation [184]
PREP TTNGKET Definitive Biomarker [185]
QPCT TTJ7YTV Definitive Biomarker [186]
RAB7A TTF6WAQ Definitive Biomarker [187]
RPH3A TT9L4J8 Definitive Biomarker [188]
RXFP3 TT64ZVP Definitive Biomarker [189]
SCN8A TT54ERL Definitive Genetic Variation [190]
SEMA4D TT5UT28 Definitive Biomarker [191]
SLC12A5 TTH6UZY Definitive Biomarker [192]
SLC6A1 TTPRKM0 Definitive Biomarker [193]
SNCG TT5TQNZ Definitive Biomarker [194]
SOD1 TTP9K3Q Definitive Biomarker [195]
ST8SIA4 TTDP8YM Definitive Biomarker [196]
TAAR1 TTIU98M Definitive Altered Expression [197]
TDP2 TTYF26D Definitive Biomarker [198]
TMEM97 TT9NXW4 Definitive Biomarker [199]
TNIK TTPB1W3 Definitive Biomarker [200]
TRPC3 TTNVC34 Definitive Biomarker [201]
TRPM4 TTJ2HKA Definitive Biomarker [8]
TRPV2 TTBECWA Definitive Biomarker [202]
UCHL1 TTX9IFP Definitive Biomarker [203]
VCP TTHNLSB Definitive Genetic Variation [204]
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⏷ Show the Full List of 219 DTT(s)
This Disease Is Related to 17 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCA2 DTJ4NEG Limited Biomarker [205]
ABCB5 DTKVEXO Limited Genetic Variation [206]
ABCD1 DTKM9DZ Limited Genetic Variation [207]
SLC12A2 DTHKL3Q Limited Biomarker [208]
SLC16A10 DTPAQJO Limited Biomarker [209]
SLC22A4 DT2EG60 Limited Biomarker [210]
SLC25A19 DTT82QK Limited Biomarker [211]
SLC25A38 DTV8SWX Limited Biomarker [212]
SLC4A3 DT4X2AH Limited Biomarker [213]
CACNB4 DTV8E46 Strong Biomarker [214]
SLC9A6 DTN0JXW Strong Biomarker [215]
SLC9A9 DT8LP62 Strong Biomarker [215]
SLC17A7 DTNK0FR Definitive Biomarker [216]
SLC30A10 DTYBI73 Definitive Biomarker [217]
SLC39A14 DTZ6IJW Definitive Biomarker [217]
SLC39A8 DTLPQGT Definitive Genetic Variation [217]
SLC52A3 DTBVQIO Definitive Biomarker [218]
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⏷ Show the Full List of 17 DTP(s)
This Disease Is Related to 16 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
FAAH DEUM1EX Limited Biomarker [219]
FXN DEXVHDB Limited Biomarker [220]
MANBA DEMH6UB Limited Altered Expression [221]
NMNAT1 DE4D159 Limited Biomarker [222]
NT5C2 DE1DOKJ Limited Altered Expression [223]
PRODH DEVJIHS Limited Biomarker [224]
TGM6 DEUWCVD Limited Biomarker [225]
CYB5R3 DE4A3BL moderate Biomarker [226]
CYP27A1 DEBS639 Strong Genetic Variation [227]
CYP2C8 DES5XRU Strong Biomarker [117]
HSD17B10 DEGSPC9 Strong Genetic Variation [228]
MTRR DE6NIY9 Strong Biomarker [115]
QARS1 DEVSTRI Strong Biomarker [229]
HPRT1 DEVXTP5 Definitive Altered Expression [230]
NMNAT2 DE2HB58 Definitive Biomarker [231]
SULT1A1 DEYWLRK Definitive Biomarker [196]
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⏷ Show the Full List of 16 DME(s)
This Disease Is Related to 339 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ABCA13 OTTHTUQN Limited Genetic Variation [206]
ACAD9 OT4HITJ6 Limited Biomarker [232]
ACMSD OTPSXPSF Limited Biomarker [233]
ADSL OTSNJALL Limited Biomarker [234]
AGFG2 OTXQZHCR Limited Biomarker [235]
AKR1E2 OT7GBQEB Limited Biomarker [236]
ALKBH1 OTADGU5D Limited Biomarker [237]
ANK3 OTJ3IRBP Limited Biomarker [238]
ANKK1 OT0OM1O0 Limited Genetic Variation [126]
APOD OTT77XW8 Limited Altered Expression [239]
APTX OTPAS5G8 Limited Genetic Variation [240]
ARFGAP1 OTM3KHIE Limited Biomarker [24]
ASCL1 OTI4X44G Limited Biomarker [66]
ASIC4 OT5POMCQ Limited Genetic Variation [241]
ATL1 OTR2788Y Limited Biomarker [242]
ATP6 OTPHOGLX Limited Genetic Variation [243]
AUTS2 OTAEXHSC Limited Biomarker [244]
BANF1 OTP7Z38L Limited Biomarker [245]
BICD2 OTVJ03NZ Limited Genetic Variation [246]
BLM OTEJOAJX Limited Genetic Variation [247]
BPIFA2 OTLFSDZD Limited Biomarker [64]
CAST OTBXZZGF Limited Genetic Variation [248]
CD244 OTSMR85N Limited Biomarker [249]
CDCA5 OTZLCQ5U Limited Altered Expression [23]
CEBPD OTNBIPMY Limited Biomarker [250]
CELF4 OT4FS4F5 Limited Biomarker [251]
CFDP1 OTXY7J96 Limited Genetic Variation [204]
COX15 OTUIYHIW Limited Genetic Variation [252]
CP OTM8JE4Y Limited Biomarker [253]
CPEB1 OTLCXC6H Limited Genetic Variation [254]
CSH1 OT33HTRR Limited Genetic Variation [255]
CSH2 OTW8JVAN Limited Genetic Variation [255]
CSTB OT3U0JF8 Limited Genetic Variation [256]
CTCF OT8ZB70U Limited Biomarker [257]
CUX1 OTU1LCNJ Limited Biomarker [57]
CXXC1 OTO10D1N Limited Biomarker [258]
CYFIP1 OTOBEH24 Limited Biomarker [259]
DARS2 OTVPFTBG Limited Genetic Variation [260]
DBN1 OTZVKG8A Limited Biomarker [261]
DCTN1 OT5B51FJ Limited Genetic Variation [246]
DENR OTXP9HOY Limited Biomarker [262]
DMRT3 OTNV7F7Q Limited Biomarker [236]
DNAAF4 OTVDYBJE Limited Biomarker [263]
DST OTHZBM4X Limited Biomarker [264]
DTNBP1 OT9UQT2S Limited Biomarker [265]
ECM1 OT1K65VW Limited Genetic Variation [266]
EIF2B1 OT4NCVY1 Limited Genetic Variation [267]
EIF2B2 OTQQMHM1 Limited Genetic Variation [267]
EIF2B4 OTTM5SX1 Limited Genetic Variation [267]
EIF2S2 OTXF0B09 Limited Genetic Variation [267]
EIF4G2 OTEO98CR Limited Genetic Variation [204]
ELOVL4 OT2M9W26 Limited Genetic Variation [268]
EN1 OT2DKIDK Limited Biomarker [269]
ERC1 OTYBGGNO Limited Genetic Variation [270]
ERCC6 OT2QZKSF Limited Genetic Variation [255]
ERCC8 OT0T4WKI Limited Genetic Variation [271]
FABP7 OTRE2H4G Limited Altered Expression [272]
FAM20C OTW5YZ7X Limited Biomarker [273]
FBXL14 OTBTN6WS Limited Biomarker [270]
FCN2 OTTHJBKZ Limited Altered Expression [23]
FMR1 OTWEV0T5 Limited Altered Expression [274]
FOXE1 OT5IR5IT Limited Genetic Variation [275]
FOXG1 OTAW57J4 Limited Biomarker [66]
FOXP2 OTVX6A59 Limited Genetic Variation [276]
GCDH OTVQMZZN Limited Biomarker [277]
GCHFR OTEOT8GI Limited Altered Expression [23]
GEMIN4 OTX7402E Limited Genetic Variation [204]
GLRA2 OTDQ0KW7 Limited Genetic Variation [278]
GLUD1 OTXKOCUH Limited Genetic Variation [279]
GOLPH3 OTDLGYM3 Limited Biomarker [280]
GPT2 OTS5VF7N Limited Genetic Variation [281]
GRIN3A OTQS9GYY Limited Biomarker [282]
GTPBP2 OTOJ1KUA Limited Biomarker [283]
H2AZ1 OT3KJJNQ Limited Biomarker [284]
HCLS1 OTX7WGYN Limited Biomarker [57]
HES5 OTW7JEHV Limited Biomarker [66]
HGS OTCYYCAC Limited Biomarker [285]
HIP1 OT7AKCFQ Limited Genetic Variation [286]
IARS2 OTDX4SCA Limited Genetic Variation [287]
IGFALS OTTWCZYM Limited Biomarker [195]
IGLON5 OTB94PY2 Limited Biomarker [288]
ITIH4 OT460OO1 Limited Genetic Variation [289]
KAT5 OTL7257A Limited Biomarker [290]
KHSRP OTDHZARB Limited Biomarker [57]
KIAA0319 OTN42Y77 Limited Biomarker [263]
KIF1B OTI1XQTO Limited Genetic Variation [291]
LGI1 OTPS77HO Limited Biomarker [292]
LIN9 OTLHW00C Limited Genetic Variation [293]
LMNB1 OT100T3P Limited Altered Expression [294]
MAB21L1 OT8FJMU8 Limited Biomarker [295]
MAD2L1BP OT2O2IUJ Limited Genetic Variation [291]
MANEAL OT248IN0 Limited Biomarker [296]
MCF2L OTEURA8N Limited Biomarker [61]
MEF2A OTV2SF6E Limited Genetic Variation [297]
MEF2C OTZGF1Y5 Limited Altered Expression [298]
METRN OTI2645G Limited Biomarker [299]
MICU1 OTS7N0LE Limited Biomarker [300]
MNAT1 OTXLOYCB Limited Altered Expression [23]
MPEG1 OT7DAO0F Limited Biomarker [56]
MPZ OTAR2YXH Limited Altered Expression [301]
NCS1 OT6JHAWM Limited Biomarker [302]
ND6 OTG47B7B Limited Genetic Variation [303]
NDE1 OT2N8Q17 Limited Biomarker [246]
NDUFS4 OTJKUYEE Limited Genetic Variation [304]
NECTIN1 OTTE5ZR6 Limited Biomarker [88]
NEFH OTMSCW5I Limited Altered Expression [274]
NEUROD1 OTZQ7QJ2 Limited Biomarker [66]
NHS OTKE8QAT Limited Biomarker [305]
NLGN1 OTGHRRFQ Limited Biomarker [306]
NOVA1 OT6A9KHY Limited Biomarker [307]
NOVA2 OTQ2X3Q4 Limited Biomarker [307]
NPC2 OTE9UEJC Limited Genetic Variation [308]
NRGN OTVGE10W Limited Biomarker [309]
OGA OT7ZBWT1 Limited Biomarker [310]
OPA3 OT6NDC1M Limited Genetic Variation [311]
OR2AG1 OTEITRP4 Limited Biomarker [312]
PAFAH1B1 OT9T2TCJ Limited Biomarker [313]
PDCD10 OTCHJTSF Limited Genetic Variation [314]
PELI1 OTMLBCLC Limited Altered Expression [85]
PENK OT8P3HMP Limited Therapeutic [315]
PICK1 OT8QE6EU Limited Biomarker [316]
PLA2G10 OTRZ2L5A Limited Biomarker [290]
PLP1 OT8CM9CX Limited Genetic Variation [317]
PQBP1 OTXCBEAH Limited Biomarker [318]
PROM2 OTT8IVS7 Limited Genetic Variation [78]
PRPF40A OT6EXJZN Limited Biomarker [319]
PRRT2 OTCJUBDO Limited Genetic Variation [320]
PSMA1 OTNBVM2U Limited Biomarker [321]
PSMD2 OT6HZHN7 Limited Genetic Variation [204]
PSPH OTV1PVAX Limited Biomarker [64]
PSPN OT54LLZJ Limited Biomarker [64]
PVALB OTZW1WVQ Limited Posttranslational Modification [322]
QDPR OTSKOIUX Limited Genetic Variation [323]
RAB27A OT9SQRWY Limited Biomarker [324]
RAB3GAP1 OT4DQ8F2 Limited Biomarker [233]
RANBP2 OTFG5CVF Limited Biomarker [235]
RETREG1 OTYOSLZX Limited Genetic Variation [280]
RGPD2 OTMUZ0HX Limited Biomarker [235]
RIDA OTW4098I Limited Biomarker [64]
RIT2 OTSNYG0D Limited Biomarker [325]
SACS OTZGXQ8A Limited Biomarker [326]
SCNM1 OT505E7T Limited Genetic Variation [327]
SELENOP OT02B8IR Limited Biomarker [328]
SEMA6A OTDQ7QAW Limited Biomarker [329]
SEPSECS OTP0FHOV Limited Genetic Variation [330]
SEPTIN9 OT1VMRFQ Limited Genetic Variation [331]
SH2D1A OTLU49I5 Limited Biomarker [249]
SHANK2 OTSQTPFQ Limited Biomarker [332]
SIGLEC7 OTNDLURR Limited Biomarker [57]
SLAMF1 OTBTT3ZQ Limited Biomarker [333]
SLC26A8 OTNCW8RJ Limited Biomarker [209]
SMPD3 OTHQBETH Limited Biomarker [334]
SOX10 OTF25ULQ Limited Biomarker [335]
SPAST OTIF3AJI Limited Biomarker [336]
SPTLC1 OTN0Z98K Limited Biomarker [337]
SRA1 OTYOGMTG Limited Genetic Variation [338]
STXBP3 OTTTYMAQ Limited Biomarker [64]
SUCLA2 OTMZD4PW Limited Biomarker [339]
SURF1 OTAINRSS Limited Genetic Variation [340]
SV2C OTIH108W Limited Biomarker [341]
SYT10 OTVV19BW Limited Altered Expression [342]
TAF15 OTNE038N Limited Genetic Variation [343]
TBP OT6C0S52 Limited Genetic Variation [344]
TMED9 OTYGAQS0 Limited Altered Expression [23]
TMEM92 OTTKJ2C0 Limited Autosomal recessive [345]
TOMM70 OT8QBYZ0 Limited Autosomal dominant [345]
TPK1 OTCHPUD0 Limited Biomarker [80]
TPPP OTCFMSUF Limited Altered Expression [23]
TRAK1 OTMQVYNP Limited Biomarker [285]
TTC36 OT90ZLHE Limited Altered Expression [85]
ADGRG1 OTQBB8NT Disputed Biomarker [346]
AGGF1 OTA7U2T8 Disputed Biomarker [347]
ARMC10 OT7YU4HK Disputed Altered Expression [348]
CALB1 OTM7IXDG Disputed Altered Expression [349]
CERS1 OT6EYRM3 Disputed Biomarker [109]
DARS1 OT0WGC2T Disputed Biomarker [350]
DISC1 OT43AW4H Disputed Biomarker [351]
EBF1 OTZ61YYH Disputed Genetic Variation [352]
EFTUD2 OT3X7QG2 Disputed Biomarker [353]
GDF1 OTZ1VRBH Disputed Biomarker [109]
GPSM2 OT6RPMRM Disputed Genetic Variation [354]
HARS1 OTHOEOTS Disputed Genetic Variation [355]
IDH3A OT5QQB5L Disputed Biomarker [211]
KLHL7 OT2OF1O8 Disputed Biomarker [356]
KRTAP10-1 OT19IXKJ Disputed Biomarker [350]
MAP1B OTVXW089 Disputed Biomarker [357]
MAP7 OTVSSJ33 Disputed Biomarker [358]
MFSD8 OT455EIC Disputed Genetic Variation [359]
MPHOSPH6 OT6E2S48 Disputed Altered Expression [301]
NACA2 OT23700G Disputed Biomarker [350]
PGP OT6QQ7OR Disputed Biomarker [360]
PIK3R3 OTXGJ8N1 Disputed Biomarker [350]
PMPCA OT5X1G9Q Disputed Biomarker [361]
POLD2 OTBNASP6 Disputed Biomarker [109]
RBM14 OTO9GMBD Disputed Biomarker [362]
RPS27 OTFXKY7P Disputed Biomarker [56]
SMG1 OTTS3SXE Disputed Biomarker [105]
STRN4 OTHK2ZN6 Disputed Biomarker [109]
TCERG1 OTH1LCGH Disputed Biomarker [363]
TRIM40 OTLKKKA5 Disputed Biomarker [350]
CNDP1 OTOYSQG7 moderate Altered Expression [364]
HCFC1 OT0UCK62 moderate Biomarker [365]
LTBP3 OTME98V7 moderate Biomarker [366]
MARCHF10 OTAYGHDM moderate Biomarker [367]
MTG1 OTC9U1LI moderate Biomarker [368]
PPM1K OTNZ4N4E moderate Genetic Variation [369]
REST OTLL92LQ moderate Posttranslational Modification [370]
SETD3 OTO5RAU2 moderate Biomarker [371]
AARS1 OTW8D813 Strong Biomarker [372]
AGFG1 OTI8ZKC4 Strong Biomarker [373]
ALDH18A1 OT6W40XU Strong Biomarker [374]
AP3D1 OTJLI0IM Strong Biomarker [375]
ARX OTBGYH25 Strong Genetic Variation [376]
ATF7IP OTU6ZA7F Strong Biomarker [377]
ATP13A2 OTKWBUGK Strong Biomarker [378]
ATXN7L3B OTUYOYAR Strong Biomarker [379]
B4GALNT1 OTCY80HS Strong Genetic Variation [380]
BCS1L OT5PY5CY Strong Genetic Variation [381]
CADPS2 OTV1FW0M Strong Genetic Variation [382]
CELF2 OTLJJ4VT Strong Biomarker [159]
CELF5 OT02OG9N Strong Biomarker [383]
CHCHD10 OTCDHAM6 Strong Genetic Variation [384]
CHI3L1 OT2Z7VJH Strong Biomarker [385]
CNKSR2 OTAGERJ2 Strong Biomarker [386]
CPLX2 OTU5QWFH Strong Biomarker [387]
CYFIP2 OTCAY35T Strong Biomarker [388]
DEGS1 OT4WXPKW Strong Genetic Variation [389]
DLG3 OTH591WK Strong Biomarker [228]
EEF1A2 OT9Z23K5 Strong Genetic Variation [390]
ENO2 OTRODL0T Strong Biomarker [391]
ERVW-1 OTWV8DXJ Strong Genetic Variation [289]
EXOSC3 OTNCF906 Strong Genetic Variation [392]
EXOSC8 OT75ACNG Strong Genetic Variation [393]
FANCD2 OTVEB5LF Strong Genetic Variation [150]
FRRS1L OT24ABVC Strong Biomarker [394]
GBA2 OTOZXG5D Strong Altered Expression [395]
GPM6B OT8Q1582 Strong Genetic Variation [396]
ID3 OTUULW5Z Strong Biomarker [117]
ILF2 OTWWVM9X Strong Biomarker [159]
INA OT1D33T4 Strong Biomarker [397]
INPPL1 OTCDAVBQ Strong Biomarker [398]
IQSEC2 OTYFRM4Q Strong Biomarker [396]
KANK1 OT2E7A6W Strong Genetic Variation [399]
KBTBD11 OTBOY3WH Strong Biomarker [159]
KIF1A OT3JVEGV Strong Genetic Variation [400]
KIFC1 OTNQDS00 Strong Biomarker [401]
LGALS14 OTOR23GX Strong Biomarker [122]
LITAF OTT5JX1F Strong Biomarker [402]
MFN2 OTPYN8A3 Strong Genetic Variation [403]
MORC2 OT52A8BJ Strong Genetic Variation [404]
MOV10 OT0KAY9G Strong Biomarker [405]
NAGA OTNUEUZY Strong Biomarker [406]
NCAN OT8OO6ZE Strong Genetic Variation [407]
NDEL1 OTAGFML5 Strong Biomarker [351]
NDUFV1 OTEVK4WW Strong Biomarker [125]
NFATC2 OTK5T6HZ Strong Biomarker [117]
NOX1 OTZPJQCC Strong Biomarker [408]
NPC1 OTRIPICX Strong Genetic Variation [409]
NR2E1 OTW47GKM Strong Biomarker [21]
NRG3 OTIFZ5CT Strong Biomarker [410]
OXA1L OTS0BFRD Strong Biomarker [411]
PARN OTTG4PE3 Strong Altered Expression [412]
PDYN OTEJ6430 Strong Biomarker [413]
PEX1 OTQJF0V7 Strong Genetic Variation [414]
PEX6 OTFAK5EF Strong Genetic Variation [414]
PIGW OTT9SMTF Strong Genetic Variation [415]
PINK1 OT50NR57 Strong Biomarker [416]
PITX2 OTWMXAOY Strong Biomarker [417]
PITX3 OTE2KT8P Strong Biomarker [123]
PLA2G6 OT5FL0WU Strong Genetic Variation [418]
POLG2 OTDBMZJB Strong Genetic Variation [125]
PRF1 OTFVXD7H Strong Genetic Variation [419]
PURA OT975ELW Strong Genetic Variation [420]
RELN OTLKMW1O Strong Biomarker [421]
RPA1 OT76POLP Strong Biomarker [422]
SEMA7A OT0ZJK64 Strong Biomarker [423]
SETX OTG3JNOQ Strong Biomarker [424]
SHMT1 OTIINA3J Strong Biomarker [115]
SHQ1 OTFBXX2H Strong Genetic Variation [425]
SPTAN1 OT6VY3A3 Strong Genetic Variation [426]
SRCIN1 OTQZNQQ5 Strong Biomarker [427]
TNFAIP1 OT37EWR0 Strong Biomarker [428]
TOLLIP OTYEO4NR Strong Biomarker [429]
TOMM40 OTZDQ29F Strong Biomarker [430]
TRAPPC4 OT3THRCA Strong Genetic Variation [431]
TTC19 OTQ0QH1P Strong Genetic Variation [432]
ABHD12 OTDP4F02 Definitive Genetic Variation [433]
AKAP1 OTIIB2JB Definitive Biomarker [434]
ANO10 OTG3BNOU Definitive Biomarker [435]
ANO2 OT650E98 Definitive Biomarker [44]
ATP1A3 OTM8EG6H Definitive Genetic Variation [436]
ATP8A2 OTDZC2ZT Definitive Genetic Variation [437]
ATXN1 OTQF0HNR Definitive Biomarker [438]
BTBD8 OT3A3RD7 Definitive Altered Expression [439]
BTN1A1 OTSQWC36 Definitive Biomarker [208]
CAMK2B OTS9YK3E Definitive Biomarker [440]
CANT1 OT1TPWQR Definitive Genetic Variation [441]
CARD11 OTRCTLYC Definitive Biomarker [442]
CDKL5 OTGL5HRV Definitive Genetic Variation [443]
CDNF OT1TP2T8 Definitive Biomarker [444]
CHD2 OTRKL6YC Definitive Biomarker [445]
CNTNAP2 OT48T2ZP Definitive Biomarker [446]
COL9A1 OTWBR27Y Definitive Genetic Variation [447]
COL9A2 OT1ZBDBV Definitive Genetic Variation [447]
COL9A3 OTCUJOEK Definitive Genetic Variation [447]
CUL1 OTXPE1UZ Definitive Biomarker [448]
DACT1 OT19Z704 Definitive Biomarker [449]
DCDC2 OTSUFH1H Definitive Biomarker [450]
DDHD2 OTUP0WHF Definitive Genetic Variation [451]
DLX6 OT0FIJHY Definitive Altered Expression [452]
EID1 OT3OI5H4 Definitive Biomarker [453]
EMX2 OT0V8OYK Definitive Altered Expression [454]
GLIS3 OTBC960E Definitive Genetic Variation [455]
IMMT OTBDSLE7 Definitive Biomarker [456]
IRF9 OTK4MYQJ Definitive Biomarker [457]
JDP2 OTW35WKX Definitive Biomarker [19]
LRPAP1 OT6DVD2Q Definitive Genetic Variation [458]
NALCN OTWY7DS0 Definitive Genetic Variation [459]
NEU3 OTQ5PQOW Definitive Biomarker [460]
NEU4 OTM16O9F Definitive Biomarker [460]
NGB OTW0SIUY Definitive Biomarker [461]
NMT1 OT42GQ3D Definitive Biomarker [462]
OSGEP OT38HX9V Definitive Biomarker [463]
PI4K2A OTL9L6MX Definitive Biomarker [464]
PIWIL1 OT7CRGZ3 Definitive Biomarker [465]
PIWIL4 OTDA9MY0 Definitive Biomarker [465]
PPP2R2B OTSFVC82 Definitive Genetic Variation [466]
RAB7B OT60A0E9 Definitive Biomarker [187]
RAPGEF5 OT53VS75 Definitive Genetic Variation [458]
RCAN1 OT1MVXC7 Definitive Altered Expression [467]
REEP1 OTEMVFX7 Definitive Genetic Variation [468]
RLN3 OTQSQMUQ Definitive Biomarker [189]
RNF20 OT9NK6ZT Definitive Biomarker [469]
SARM1 OTEP4I5O Definitive Biomarker [470]
SHANK1 OTK8PV0S Definitive Biomarker [471]
SYNGAP1 OT41HVYQ Definitive Genetic Variation [472]
TBC1D24 OTKZUSMD Definitive Genetic Variation [473]
TPI1 OT14KP4B Definitive Biomarker [321]
TRIB2 OTHSX3MX Definitive Biomarker [44]
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⏷ Show the Full List of 339 DOT(s)

References

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68 Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.Cell Chem Biol. 2019 May 16;26(5):674-685.e6. doi: 10.1016/j.chembiol.2019.02.002. Epub 2019 Mar 7.
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74 Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease.Am J Physiol Cell Physiol. 2008 Sep;295(3):C722-31. doi: 10.1152/ajpcell.00110.2008. Epub 2008 Jun 25.
75 MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition.Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1492-1499. doi: 10.1016/j.bbadis.2017.04.018. Epub 2017 Apr 19.
76 Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases.Front Neurosci. 2019 Aug 28;13:862. doi: 10.3389/fnins.2019.00862. eCollection 2019.
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463 tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy. Eur J Hum Genet. 2017 May;25(5):545-551. doi: 10.1038/ejhg.2017.30. Epub 2017 Mar 8.
464 The Many Roles of Type II Phosphatidylinositol 4-Kinases in Membrane Trafficking: New Tricks for Old Dogs.Bioessays. 2018 Feb;40(2). doi: 10.1002/bies.201700145. Epub 2017 Dec 27.
465 PIWI Proteins and piRNAs in the Nervous System.Mol Cells. 2019 Dec 31;42(12):828-835. doi: 10.14348/molcells.2019.0241.
466 Generation of three spinocerebellar ataxia type-12 patients derived induced pluripotent stem cell lines (IGIBi002-A, IGIBi003-A and IGIBi004-A).Stem Cell Res. 2018 Aug;31:216-221. doi: 10.1016/j.scr.2018.08.008. Epub 2018 Aug 14.
467 The neuronal and endocrine roles of RCAN1 in health and disease.Clin Exp Pharmacol Physiol. 2018 Apr;45(4):377-383. doi: 10.1111/1440-1681.12884. Epub 2017 Nov 29.
468 Spastic paraplegia type 31: A novel REEP1 splice site donor variant and expansion of the phenotype variability.Parkinsonism Relat Disord. 2018 Jan;46:79-83. doi: 10.1016/j.parkreldis.2017.10.012. Epub 2017 Oct 21.
469 RNF20 controls astrocytic differentiation through epigenetic regulation of STAT3 in the developing brain.Cell Death Differ. 2018 Feb;25(2):294-306. doi: 10.1038/cdd.2017.157. Epub 2017 Oct 6.
470 Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.J Exp Med. 2019 Feb 4;216(2):294-303. doi: 10.1084/jem.20181040. Epub 2019 Jan 14.
471 Neocortical SHANK1 regulation of forebrain dependent associative learning.Neurobiol Learn Mem. 2018 Nov;155:173-179. doi: 10.1016/j.nlm.2018.07.009. Epub 2018 Jul 24.
472 Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1(+/-) mice.Pharmacol Rep. 2018 Aug;70(4):777-783. doi: 10.1016/j.pharep.2018.02.021. Epub 2018 Jun 23.
473 The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons.Hum Mol Genet. 2019 Feb 15;28(4):584-597. doi: 10.1093/hmg/ddy370.