Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTGT38E3)

DOT Name Transcription factor SOX-30 (SOX30)
Gene Name SOX30
Related Disease
Neoplasm ( )
Adenocarcinoma ( )
Advanced cancer ( )
Bladder cancer ( )
Colon cancer ( )
Colon carcinoma ( )
Hepatocellular carcinoma ( )
Lung adenocarcinoma ( )
Lung carcinoma ( )
Male infertility ( )
Non-small-cell lung cancer ( )
Squamous cell carcinoma ( )
Urinary bladder cancer ( )
Urinary bladder neoplasm ( )
Lung cancer ( )
Lung neoplasm ( )
Lymphoma ( )
UniProt ID
SOX30_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
7JJK
Pfam ID
PF00505
Sequence
MERARPEPPPQPRPLRPAPPPLPVEGTSFWAAAMEPPPSSPTLSAAASATLASSCGEAVA
SGLQPAVRRLLQVKPEQVLLLPQPQAQNEEAAASSAQARLLQFRPDLRLLQPPTASDGAT
SRPELHPVQPLALHVKAKKQKLGPSLDQSVGPRGAVETGPRASRVVKLEGPGPALGYFRG
DEKGKLEAEEVMRDSMQGGAGKSPAAIREGVIKTEEPERLLEDCRLGAEPASNGLVHGSA
EVILAPTSGAFGPHQQDLRIPLTLHTVPPGARIQFQGAPPSELIRLTKVPLTPVPTKMQS
LLEPSVKIETKDVPLTVLPSDAGIPDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANP
AANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGKRKRFPLSV
SNVFSGTTQNIISTNPTTVYPYRSPTYSVVIPSLQNPITHPVGETSPAIQLPTPAVQSPS
PVTLFQPSVSSAAQVAVQDPSLPVYPALPPQRFTGPSQTDTHQLHSEATHTVKQPTPVSL
ESANRISSSASTAHARFATSTIQPPREYSSVSPCPRSAPIPQASPIPHPHVYQPPPLGHP
ATLFGTPPRFSFHHPYFLPGPHYFPSSTCPYSRPPFGYGNFPSSMPECLSYYEDRYPKHE
GIFSTLNRDYSFRDYSSECTHSENSRSCENMNGTSYYNSHSHSGEENLNPVPQLDIGTLE
NVFTAPTSTPSSIQQVNVTDSDEEEEEKVLRDL
Function
Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4.

Molecular Interaction Atlas (MIA) of This DOT

17 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Neoplasm DISZKGEW Definitive Altered Expression [1]
Adenocarcinoma DIS3IHTY Strong Altered Expression [2]
Advanced cancer DISAT1Z9 Strong Biomarker [2]
Bladder cancer DISUHNM0 Strong Altered Expression [3]
Colon cancer DISVC52G Strong Altered Expression [4]
Colon carcinoma DISJYKUO Strong Altered Expression [4]
Hepatocellular carcinoma DIS0J828 Strong Biomarker [5]
Lung adenocarcinoma DISD51WR Strong Biomarker [2]
Lung carcinoma DISTR26C Strong Biomarker [6]
Male infertility DISY3YZZ Strong Genetic Variation [7]
Non-small-cell lung cancer DIS5Y6R9 Strong Altered Expression [2]
Squamous cell carcinoma DISQVIFL Strong Altered Expression [2]
Urinary bladder cancer DISDV4T7 Strong Altered Expression [3]
Urinary bladder neoplasm DIS7HACE Strong Altered Expression [3]
Lung cancer DISCM4YA Disputed Biomarker [6]
Lung neoplasm DISVARNB Disputed Biomarker [8]
Lymphoma DISN6V4S Limited Biomarker [9]
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⏷ Show the Full List of 17 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Transcription factor SOX-30 (SOX30). [10]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Transcription factor SOX-30 (SOX30). [15]
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5 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Estradiol DMUNTE3 Approved Estradiol decreases the expression of Transcription factor SOX-30 (SOX30). [11]
Quercetin DM3NC4M Approved Quercetin increases the expression of Transcription factor SOX-30 (SOX30). [12]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide increases the expression of Transcription factor SOX-30 (SOX30). [13]
Decitabine DMQL8XJ Approved Decitabine increases the expression of Transcription factor SOX-30 (SOX30). [14]
Deguelin DMXT7WG Investigative Deguelin increases the expression of Transcription factor SOX-30 (SOX30). [16]
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References

1 SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer.Endocr Relat Cancer. 2019 Mar;26(3):303-319. doi: 10.1530/ERC-18-0529.
2 SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients.Respir Res. 2018 Dec 4;19(1):241. doi: 10.1186/s12931-018-0952-3.
3 Decreased expression of SRY-box containing gene 30 is related to malignant phenotypes of human bladder cancer and correlates with poor prognosis.BMC Cancer. 2018 Jun 7;18(1):642. doi: 10.1186/s12885-018-4560-x.
4 MicroRNA-645 is an oncogenic regulator in colon cancer.Oncogenesis. 2017 May 15;6(5):e335. doi: 10.1038/oncsis.2017.37.
5 MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation.Int J Biol Macromol. 2019 Jan;121:214-222. doi: 10.1016/j.ijbiomac.2018.10.032. Epub 2018 Oct 9.
6 SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of -Catenin in Lung Cancer.EBioMedicine. 2018 May;31:253-266. doi: 10.1016/j.ebiom.2018.04.026. Epub 2018 May 5.
7 Epigenetic Inactivation of SOX30 Is Associated with Male Infertility and Offers a Therapy Target for Non-obstructive Azoospermia.Mol Ther Nucleic Acids. 2020 Mar 6;19:72-83. doi: 10.1016/j.omtn.2019.10.038. Epub 2019 Nov 14.
8 SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma.J Exp Clin Cancer Res. 2018 May 31;37(1):111. doi: 10.1186/s13046-018-0778-3.
9 Different expressions of miR-125b and SOX30 in malignant lymphomas and their significance.J BUON. 2018 Jul-Aug;23(4):1179-1184.
10 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
11 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
12 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
13 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
14 SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer. Oncogene. 2015 Aug 13;34(33):4391-402. doi: 10.1038/onc.2014.370. Epub 2014 Dec 1.
15 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
16 Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway. Cancer Prev Res (Phila). 2009 Nov;2(11):942-50. doi: 10.1158/1940-6207.CAPR-08-0232. Epub 2009 Oct 27.