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Pemetrexed FDA Label
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Somatic mutation of the Caspase-5 gene in human lung cancer.Int J Mol Med. 2003 Oct;12(4):443-6. doi: 10.3892/ijmm.12.4.443.
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Systemic transduction of p16(INK4a) antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice.Oncol Lett. 2019 Jan;17(1):1203-1210. doi: 10.3892/ol.2018.9655. Epub 2018 Nov 1.
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Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells.Oncol Rep. 2013 Jul;30(1):269-75. doi: 10.3892/or.2013.2436. Epub 2013 Apr 29.
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Oncogenic Potential of CYP24A1 in Lung Adenocarcinoma.J Thorac Oncol. 2017 Feb;12(2):269-280. doi: 10.1016/j.jtho.2016.10.010. Epub 2016 Oct 26.
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Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells.Oncotarget. 2016 Aug 16;7(33):52710-52728. doi: 10.18632/oncotarget.10348.
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Desmoglein 3 as a prognostic factor in lung cancer.Hum Pathol. 2007 Feb;38(2):276-83. doi: 10.1016/j.humpath.2006.08.006. Epub 2006 Nov 3.
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ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas.Cancer Res. 2015 Mar 15;75(6):1035-45. doi: 10.1158/0008-5472.CAN-13-1625. Epub 2015 Jan 16.
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GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer.Mol Cancer. 2016 Mar 18;15:25. doi: 10.1186/s12943-016-0508-4.
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Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years.BMC Cancer. 2008 Feb 25;8:60. doi: 10.1186/1471-2407-8-60.
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IMP3 expression in small-intestine neuroendocrine neoplasms: a new predictor of recurrence.Endocrine. 2017 Nov;58(2):360-367. doi: 10.1007/s12020-017-1249-x. Epub 2017 Feb 17.
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Diesel exhaust particle promotes tumor lung metastasis via the induction of BLT1-mediated neutrophilic lung inflammation.Cytokine. 2018 Nov;111:530-540. doi: 10.1016/j.cyto.2018.05.024. Epub 2018 Jun 5.
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Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.J Toxicol Sci. 2009 Apr;34(2):163-74. doi: 10.2131/jts.34.163.
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Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking -catenin and MAPK signaling.Oncotarget. 2017 Aug 27;8(41):69264-69280. doi: 10.18632/oncotarget.20566. eCollection 2017 Sep 19.
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Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells.J Immunol. 2019 Feb 1;202(3):991-1002. doi: 10.4049/jimmunol.1800736. Epub 2018 Dec 19.
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Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of 1-antitrypsin in lung cancer.Mol Oncol. 2012 Aug;6(4):405-17. doi: 10.1016/j.molonc.2012.03.005. Epub 2012 Apr 2.
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SLC27A4 regulate ATG4B activity and control reactions to chemotherapeutics-induced autophagy in human lung cancer cells.Tumour Biol. 2016 May;37(5):6943-52. doi: 10.1007/s13277-015-4587-4. Epub 2015 Dec 11.
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Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells. Toxicol Appl Pharmacol. 2016 Jan 1;290:74-85.
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Expression of telomeric repeat binding factor 1 protein in nonsmall cell lung cancer with human telomerase reverse transcriptase positive. Int J Surg Pathol. 2008 Oct;16(4):414-8.
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Expression of cell proliferating genes in patients with non-small cell lung cancer by immunohistochemistry and cDNA profiling.Oncol Rep. 2005 May;13(5):837-46.
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Asbestos-associated genome-wide DNA methylation changes in lung cancer.Int J Cancer. 2017 Nov 15;141(10):2014-2029. doi: 10.1002/ijc.30897. Epub 2017 Aug 2.
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Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.Sci Rep. 2017 Dec 13;7(1):17530. doi: 10.1038/s41598-017-17836-7.
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Ku80 is differentially expressed in human lung carcinomas and upregulated in response to irradiation in mice.DNA Cell Biol. 2011 Dec;30(12):987-94. doi: 10.1089/dna.2010.1196. Epub 2011 Jun 11.
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Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity.Front Immunol. 2019 Jun 18;10:1379. doi: 10.3389/fimmu.2019.01379. eCollection 2019.
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Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population.DNA Cell Biol. 2008 Aug;27(8):443-8. doi: 10.1089/dna.2007.0719.
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An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers.Clin Cancer Res. 2006 Mar 1;12(5):1507-14. doi: 10.1158/1078-0432.CCR-05-2049.
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Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.Nat Genet. 2014 Jul;46(7):736-41. doi: 10.1038/ng.3002. Epub 2014 Jun 1.
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Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis.Cancers (Basel). 2019 Mar 6;11(3):320. doi: 10.3390/cancers11030320.
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Clinical implications of microsomal prostaglandin e synthase-1 overexpression in human non-small-cell lung cancer.Ann Surg Oncol. 2006 Sep;13(9):1224-34. doi: 10.1245/s10434-006-9001-4. Epub 2006 Sep 3.
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The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo.J Cell Mol Med. 2008 Dec;12(6B):2781-9. doi: 10.1111/j.1582-4934.2008.00215.x. Epub 2008 Jan 11.
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Expression of maspin in non-small-cell lung cancer: correlation with clinical features.Clin Lung Cancer. 2008 Nov;9(6):361-6. doi: 10.3816/CLC.2008.n.052.
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The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.Leukemia. 2010 Sep;24(9):1641-55. doi: 10.1038/leu.2010.138. Epub 2010 Jun 24.
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Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma.J Biol Chem. 2006 Sep 15;281(37):26943-50. doi: 10.1074/jbc.M604145200. Epub 2006 Jul 11.
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Identification of polymorphisms in the XIAP gene and analysis of association with lung cancer risk in a Korean population.Cancer Genet Cytogenet. 2008 Jan 1;180(1):6-13. doi: 10.1016/j.cancergencyto.2007.07.021.
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Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.Cell Death Differ. 2015 May;22(5):719-30. doi: 10.1038/cdd.2014.159. Epub 2014 Oct 10.
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Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence.J Biol Chem. 2018 Feb 2;293(5):1794-1809. doi: 10.1074/jbc.M117.815902. Epub 2017 Dec 15.
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Lung tumourigenesis in a conditional Cul4A transgenic mouse model.J Pathol. 2014 Jun;233(2):113-23. doi: 10.1002/path.4352.
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Epigenetic silencing of cell cycle regulatory genes during 3-methylcholanthrene and diethylnitrosamine-induced multistep rat lung cancer.Mol Carcinog. 2010 Jun;49(6):556-65. doi: 10.1002/mc.20621.
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Use of C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer.Mol Med Rep. 2015 May;11(5):3285-90. doi: 10.3892/mmr.2015.3200. Epub 2015 Jan 14.
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Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy.Clin Cancer Res. 2018 May 1;24(9):2138-2147. doi: 10.1158/1078-0432.CCR-17-3555. Epub 2018 Feb 6.
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Decreased expression of cytochrome p450 1B1 in non-small cell lung cancer.Biomed Pharmacother. 2017 Nov;95:339-345. doi: 10.1016/j.biopha.2017.08.056. Epub 2017 Sep 12.
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Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.PLoS One. 2015 Jul 1;10(7):e0126113. doi: 10.1371/journal.pone.0126113. eCollection 2015.
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Nuclear overexpression of the E2F3 transcription factor in human lung cancer.Lung Cancer. 2006 Nov;54(2):155-62. doi: 10.1016/j.lungcan.2006.07.005. Epub 2006 Aug 30.
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The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor.Am J Respir Cell Mol Biol. 2003 Dec;29(6):694-701. doi: 10.1165/rcmb.2003-0061OC. Epub 2003 Jun 19.
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CADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis.Cancer Sci. 2019 Jul;110(7):2284-2295. doi: 10.1111/cas.14040. Epub 2019 May 29.
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Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer.Mol Cancer. 2014 Oct 24;13:240. doi: 10.1186/1476-4598-13-240.
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MAP3K3 expression in tumor cells and tumor-infiltrating lymphocytes is correlated with favorable patient survival in lung cancer.Sci Rep. 2015 Jun 19;5:11471. doi: 10.1038/srep11471.
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Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases.Cancer Med. 2018 Jun;7(6):2654-2664. doi: 10.1002/cam4.1518. Epub 2018 May 7.
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Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.Cancer Res. 2007 Sep 1;67(17):8051-7. doi: 10.1158/0008-5472.CAN-07-1022.
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Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines.J Pathol. 2003 Jul;200(3):336-47. doi: 10.1002/path.1367.
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The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.J Cell Biol. 2017 Mar 6;216(3):641-656. doi: 10.1083/jcb.201604025. Epub 2017 Feb 13.
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Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4336-44. doi: 10.1158/1078-0432.CCR-07-0015.
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Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer.Chest. 2008 Sep;134(3):582-588. doi: 10.1378/chest.08-0600.
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Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas.PLoS One. 2014 Oct 15;9(10):e110094. doi: 10.1371/journal.pone.0110094. eCollection 2014.
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