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Mitomycin FDA Label
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| 2 |
Thiotepa FDA Label
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Valrubicin FDA Label
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Prospective Validation of an mRNA-based Urine Test for Surveillance of Patients with Bladder Cancer.Eur Urol. 2019 May;75(5):853-860. doi: 10.1016/j.eururo.2018.11.055. Epub 2018 Dec 12.
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Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta-analysis.Cancer Med. 2019 Jun;8(6):2717-2729. doi: 10.1002/cam4.2152. Epub 2019 Apr 5.
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CCL18 enhances migration, invasion and EMT by binding CCR8 in bladder cancer cells.Mol Med Rep. 2019 Mar;19(3):1678-1686. doi: 10.3892/mmr.2018.9791. Epub 2018 Dec 24.
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CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status.Clin Cancer Res. 2019 Jan 1;25(1):390-402. doi: 10.1158/1078-0432.CCR-18-0685. Epub 2018 Sep 21.
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Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.J Exp Med. 2019 Nov 4;216(11):2635-2652. doi: 10.1084/jem.20190251. Epub 2019 Sep 10.
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High-soluble CGA levels are associated with poor survival in bladder cancer.Endocr Connect. 2019 May 1;8(5):625-633. doi: 10.1530/EC-19-0068.
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| 10 |
Multiple recurrences and risk of disease progression in patients with primary low-grade (TaG1) non-muscle-invasive bladder cancer and with low and intermediate EORTC-risk score.PLoS One. 2019 Feb 27;14(2):e0211721. doi: 10.1371/journal.pone.0211721. eCollection 2019.
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Caspase recruitment domain family member 10 regulates carbamoyl phosphate synthase 1 and promotes cancer growth in bladder cancer cells.J Cell Mol Med. 2019 Dec;23(12):8128-8138. doi: 10.1111/jcmm.14683. Epub 2019 Sep 29.
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Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer.Clin Cancer Res. 2019 Jun 15;25(12):3689-3701. doi: 10.1158/1078-0432.CCR-18-1515. Epub 2019 Mar 7.
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Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.Arch Environ Occup Health. 2015;70(1):19-26. doi: 10.1080/19338244.2013.853646.
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Soluble HER3 predicts survival in bladder cancer patients.Oncol Lett. 2018 Feb;15(2):1783-1788. doi: 10.3892/ol.2017.7470. Epub 2017 Nov 22.
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Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis.J Urol. 2000 Jul;164(1):209-13.
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Genoproteomic mining of urothelial cancer suggests {gamma}-glutamyl hydrolase and diazepam-binding inhibitor as putative urinary markers of outcome after chemotherapy.Am J Pathol. 2009 Nov;175(5):1824-30. doi: 10.2353/ajpath.2009.090155. Epub 2009 Oct 8.
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Activation of type 4 metabotropic glutamate receptor promotes cell apoptosis and inhibits proliferation in bladder cancer.J Cell Physiol. 2019 Mar;234(3):2741-2755. doi: 10.1002/jcp.27089. Epub 2018 Aug 26.
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Does phosphorylation of cofilin affect the progression of human bladder cancer?.BMC Cancer. 2013 Feb 1;13:45. doi: 10.1186/1471-2407-13-45.
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GSTO1*C/GSTO2*G haplotype is associated with risk of transitional cell carcinoma of urinary bladder.Int Urol Nephrol. 2015 Apr;47(4):625-30. doi: 10.1007/s11255-015-0933-0. Epub 2015 Feb 26.
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Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer.FEBS Open Bio. 2019 Feb 21;9(4):693-706. doi: 10.1002/2211-5463.12600. eCollection 2019 Apr.
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Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer.J Clin Invest. 2020 Jan 2;130(1):404-421. doi: 10.1172/JCI130892.
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HtrA1 in human urothelial bladder cancer: a secreted protein and a potential novel biomarker.Int J Cancer. 2013 Dec 1;133(11):2650-61. doi: 10.1002/ijc.28280. Epub 2013 Jul 9.
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Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers.Carcinogenesis. 2014 Dec;35(12):2698-705. doi: 10.1093/carcin/bgu203. Epub 2014 Sep 19.
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Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene.Arch Toxicol. 2012 Feb;86(2):195-203. doi: 10.1007/s00204-011-0747-5. Epub 2011 Sep 3.
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Immune analysis of expression of IL-17 relative ligands and their receptors in bladder cancer: comparison with polyp and cystitis.BMC Immunol. 2016 Oct 3;17(1):36. doi: 10.1186/s12865-016-0174-8.
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Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer.Br J Cancer. 2006 May 22;94(10):1465-71. doi: 10.1038/sj.bjc.6603099.
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N(6)-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer.EBioMedicine. 2019 Sep;47:195-207. doi: 10.1016/j.ebiom.2019.07.068. Epub 2019 Aug 10.
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Large-scale profiling of serum metabolites in African American and European American patients with bladder cancer reveals metabolic pathways associated with patient survival.Cancer. 2019 Mar 15;125(6):921-932. doi: 10.1002/cncr.31890. Epub 2019 Jan 2.
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Inhibition of autophagy enhances the anticancer effect of enzalutamide on bladder cancer.Biomed Pharmacother. 2019 Dec;120:109490. doi: 10.1016/j.biopha.2019.109490. Epub 2019 Sep 28.
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LIMK2 acts as an oncogene in bladder cancer and its functional SNP in the microRNA-135a binding site affects bladder cancer risk.Int J Cancer. 2019 Mar 15;144(6):1345-1355. doi: 10.1002/ijc.31757. Epub 2018 Nov 4.
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Lymphotoxin receptor activation promotes bladder cancer in a nuclear factor-B-dependent manner.Mol Med Rep. 2015 Feb;11(2):783-90. doi: 10.3892/mmr.2014.2826. Epub 2014 Oct 30.
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Inhibition of MELK produces potential anti-tumour effects in bladder cancer by inducing G1/S cell cycle arrest via the ATM/CHK2/p53 pathway.J Cell Mol Med. 2020 Jan;24(2):1804-1821. doi: 10.1111/jcmm.14878. Epub 2019 Dec 10.
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TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer.Br J Cancer. 2019 Mar;120(5):555-564. doi: 10.1038/s41416-019-0397-6. Epub 2019 Feb 15.
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Neural precursor cell expressed, developmentally downregulated 8 promotes tumor progression and predicts poor prognosis of patients with bladder cancer.Cancer Sci. 2019 Jan;110(1):458-467. doi: 10.1111/cas.13865. Epub 2018 Dec 10.
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Long non-coding RNA ARAP1-AS1 promotes the progression of bladder cancer by regulating miR-4735-3p/NOTCH2 axis.Cancer Biol Ther. 2019;20(4):552-561. doi: 10.1080/15384047.2018.1538613. Epub 2018 Nov 7.
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Upregulation of lncRNA snoRNA host gene 6 regulates NUAK family SnF1-like kinase-1 expression by competitively binding microRNA-125b and interacting with Snail1/2 in bladder cancer.J Cell Biochem. 2019 Jan;120(1):357-367. doi: 10.1002/jcb.27387. Epub 2018 Aug 30.
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MiR-34b-3p Represses the Multidrug-Chemoresistance of Bladder Cancer Cells by Regulating the CCND2 and P2RY1 Genes.Med Sci Monit. 2019 Feb 19;25:1323-1335. doi: 10.12659/MSM.913746.
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Canine urothelial carcinoma: genomically aberrant and comparatively relevant.Chromosome Res. 2015 Jun;23(2):311-31. doi: 10.1007/s10577-015-9471-y. Epub 2015 Mar 18.
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Prohibitin gene is overexpressed but not mutated in rat bladder carcinomas and cell lines.Cancer Lett. 1994 Aug 15;83(1-2):201-7. doi: 10.1016/0304-3835(94)90320-4.
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PPAR activation serves as therapeutic strategy against bladder cancer via inhibiting PI3K-Akt signaling pathway.BMC Cancer. 2019 Mar 7;19(1):204. doi: 10.1186/s12885-019-5426-6.
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Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M.Cell Mol Life Sci. 2018 Mar;75(5):939-963. doi: 10.1007/s00018-017-2681-z. Epub 2017 Oct 25.
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NFB2 p52 stabilizes rhogdi mRNA by inhibiting AUF1 protein degradation via a miR-145/Sp1/USP8-dependent axis.Mol Carcinog. 2019 May;58(5):777-793. doi: 10.1002/mc.22970. Epub 2019 Jan 29.
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RalBP1 is necessary for metastasis of human cancer cell lines. Neoplasia. 2010 Dec;12(12):1003-12.
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Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotubes.Sci Adv. 2019 Sep 25;5(9):eaaw6499. doi: 10.1126/sciadv.aaw6499. eCollection 2019 Sep.
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RSPO3 promotes the aggressiveness of bladder cancer via Wnt/-catenin and Hedgehog signaling pathways.Carcinogenesis. 2019 Apr 29;40(2):360-369. doi: 10.1093/carcin/bgy140.
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Sphingosine 1 phosphate receptor-1 (S1P1) promotes tumor-associated regulatory T cell expansion: leading to poor survival in bladder cancer.Cell Death Dis. 2019 Jan 18;10(2):50. doi: 10.1038/s41419-018-1298-y.
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Semaphorin 4D promotes the proliferation and metastasis of bladder cancer by activating the PI3K/AKT pathway.Tumori. 2019 Jun;105(3):231-242. doi: 10.1177/0300891618811280. Epub 2019 Jan 24.
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Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection.Biochem Biophys Res Commun. 2011 Oct 22;414(2):344-9. doi: 10.1016/j.bbrc.2011.09.073. Epub 2011 Sep 17.
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Mitogenic signal transduction caused by monomethylarsonous acid in human bladder cells: role in arsenic-induced carcinogenesis. Toxicol Sci. 2007 Feb;95(2):321-30.
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TACC3 transcriptionally upregulates E2F1 to promote cell growth and confer sensitivity to cisplatin in bladder cancer.Cell Death Dis. 2018 Jan 22;9(2):72. doi: 10.1038/s41419-017-0112-6.
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Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines.Eur J Med Chem. 2020 Jan 1;185:111832. doi: 10.1016/j.ejmech.2019.111832. Epub 2019 Oct 31.
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Four novel biomarkers for bladder cancer identified by weighted gene coexpression network analysis.J Cell Physiol. 2019 Aug;234(10):19073-19087. doi: 10.1002/jcp.28546. Epub 2019 Mar 29.
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Expression of the fluoropyrimidine-metabolizing enzymes in bladder cancers as measured by the Danenberg tumor profile.Oncol Res. 2009;18(4):153-62. doi: 10.3727/096504009790217371.
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Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer.Cancer Med. 2013 Aug;2(4):488-95. doi: 10.1002/cam4.95. Epub 2013 Jun 10.
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RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling.Cancer Res. 2020 Jan 15;80(2):219-233. doi: 10.1158/0008-5472.CAN-18-2796. Epub 2019 Sep 24.
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Mutations in CDKN2A and the FGFR3 genes on bladder cancer diagnosis: a systematic review and meta-analysis.World J Urol. 2019 Oct;37(10):2001-2007. doi: 10.1007/s00345-019-02779-7. Epub 2019 Apr 27.
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The clinical significance of PINX1 expression in papillary thyroid carcinoma.Hum Pathol. 2018 Nov;81:176-183. doi: 10.1016/j.humpath.2018.07.004. Epub 2018 Jul 17.
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Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.Mol Carcinog. 2018 May;57(5):606-618. doi: 10.1002/mc.22784. Epub 2018 Feb 1.
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ACR Appropriateness Criteria Post-Treatment Surveillance of Bladder Cancer.J Am Coll Radiol. 2019 Nov;16(11S):S417-S427. doi: 10.1016/j.jacr.2019.05.026.
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Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.Oncogene. 2020 Oct;39(40):6265-6285. doi: 10.1038/s41388-019-0902-7. Epub 2019 Aug 5.
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The significance of calprotectin, CD147, APOA4 and DJ-1 in non-invasive detection of urinary bladder carcinoma.Neoplasma. 2019 Nov;66(6):1019-1023. doi: 10.4149/neo_2019_190124N74. Epub 2019 Oct 8.
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Implication of RAF and RKIP genes in urinary bladder cancer.Pathol Oncol Res. 2011 Jun;17(2):181-90. doi: 10.1007/s12253-010-9295-1. Epub 2010 Sep 18.
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Expression of bone morphogenetic protein-10 (BMP10) in human urothelial cancer of the bladder and its effects on the aggressiveness of bladder cancer cells in vitro.Anticancer Res. 2013 May;33(5):1917-25.
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The Immune Checkpoint Molecule CD200 Is Associated with Tumor Grading and Metastasis in Bladder Cancer.Anticancer Res. 2018 May;38(5):2749-2754. doi: 10.21873/anticanres.12517.
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Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer.Cancer Res. 2004 Dec 15;64(24):8932-8. doi: 10.1158/0008-5472.CAN-04-0505.
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Granulocyte colony-stimulating factor receptor signals for beta1-integrin expression and adhesion in bladder cancer.Urology. 2004 Jan;63(1):177-83. doi: 10.1016/s0090-4295(03)00786-6.
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Collaborative response to arsenic-contaminated soil in an Appalachian Kentucky neighborhood.J Toxicol Environ Health A. 2019;82(12):697-701. doi: 10.1080/15287394.2019.1641872. Epub 2019 Jul 15.
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Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.Oncol Lett. 2019 Jul;18(1):219-226. doi: 10.3892/ol.2019.10310. Epub 2019 May 3.
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Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture.Cancer Sci. 2019 Sep;110(9):2806-2821. doi: 10.1111/cas.14118. Epub 2019 Jul 23.
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Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.Nat Med. 2019 Jul;25(7):1073-1081. doi: 10.1038/s41591-019-0499-y. Epub 2019 Jul 3.
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EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival.Oncogene. 2006 Feb 2;25(5):769-80. doi: 10.1038/sj.onc.1209108.
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BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1.Int J Mol Sci. 2018 Apr 8;19(4):1116. doi: 10.3390/ijms19041116.
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Discovery of a nanomolar inhibitor of the human glyoxalase-I enzyme using structure-based poly-pharmacophore modelling and molecular docking.J Comput Aided Mol Des. 2019 Sep;33(9):799-815. doi: 10.1007/s10822-019-00226-8. Epub 2019 Oct 19.
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Downregulation of HDGF inhibits the tumorigenesis of bladder cancer cells by inactivating the PI3K-AKT signaling pathway.Cancer Manag Res. 2019 Aug 22;11:7909-7923. doi: 10.2147/CMAR.S215341. eCollection 2019.
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Correlation of IL-31 gene polymorphisms with susceptibility and clinical recurrence of bladder cancer.Fam Cancer. 2018 Oct;17(4):577-585. doi: 10.1007/s10689-017-0060-4.
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IMP3 overexpression occurs in various important cancer types and is linked to aggressive tumor features: A tissue microarray study on 8,877 human cancers and normal tissues.Oncol Rep. 2018 Jan;39(1):3-12. doi: 10.3892/or.2017.6072. Epub 2017 Nov 2.
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MiR-652-3p promotes bladder cancer migration and invasion by targeting KCNN3.Eur Rev Med Pharmacol Sci. 2019 Oct;23(20):8806-8812. doi: 10.26355/eurrev_201910_19275.
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Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1.Oncogene. 2017 Jul 6;36(27):3868-3877. doi: 10.1038/onc.2017.13. Epub 2017 Mar 6.
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Upregulation of JMJD2A promotes migration and invasion in bladder cancer through regulation of SLUG.Oncol Rep. 2019 Oct;42(4):1431-1440. doi: 10.3892/or.2019.7246. Epub 2019 Jul 23.
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KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo.Dis Markers. 2019 Jul 3;2019:4824902. doi: 10.1155/2019/4824902. eCollection 2019.
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Carcinogenic role of K-Ras-ERK1/2 signaling in bladder cancer via inhibition of H1.2 phosphorylation at T146.J Cell Physiol. 2019 Nov;234(11):21135-21144. doi: 10.1002/jcp.28716. Epub 2019 Apr 29.
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BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway.Free Radic Biol Med. 2010 Sep 15;49(6):1072-81. doi: 10.1016/j.freeradbiomed.2010.06.023. Epub 2010 Jun 28.
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The RNA binding protein Musashi1 regulates apoptosis, gene expression and stress granule formation in urothelial carcinoma cells.J Cell Mol Med. 2011 May;15(5):1210-24. doi: 10.1111/j.1582-4934.2010.01090.x. Epub 2010 May 14.
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Long noncoding RNA NNT-AS1 enhances the malignant phenotype of bladder cancer by acting as a competing endogenous RNA on microRNA-496 thereby increasing HMGB1 expression.Aging (Albany NY). 2019 Dec 17;11(24):12624-12640. doi: 10.18632/aging.102591. Epub 2019 Dec 17.
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Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility.Nat Commun. 2019 May 29;10(1):2356. doi: 10.1038/s41467-019-10241-w.
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Aberrantly expressed PLOD1 promotes cancer aggressiveness in bladder cancer: a potential prognostic marker and therapeutic target.Mol Oncol. 2019 Sep;13(9):1898-1912. doi: 10.1002/1878-0261.12532. Epub 2019 Jun 27.
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Overexpression of exchange protein directly activated by cAMP-1 (EPAC1) attenuates bladder cancer cell migration.Biochem Biophys Res Commun. 2018 Jan 1;495(1):64-70. doi: 10.1016/j.bbrc.2017.10.142. Epub 2017 Oct 28.
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Gene promoter methylation and cancer: An umbrella review.Gene. 2019 Aug 20;710:333-340. doi: 10.1016/j.gene.2019.06.023. Epub 2019 Jun 13.
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Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer.Int J Biol Sci. 2019 Jun 4;15(8):1610-1617. doi: 10.7150/ijbs.32518. eCollection 2019.
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SLC14A1: a novel target for human urothelial cancer.Clin Transl Oncol. 2017 Dec;19(12):1438-1446. doi: 10.1007/s12094-017-1693-3. Epub 2017 Jun 6.
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Validation of survivin and HMGA2 as biomarkers for cisplatin resistance in bladder cancer.Urol Oncol. 2019 Nov;37(11):810.e7-810.e15. doi: 10.1016/j.urolonc.2019.04.015. Epub 2019 Apr 30.
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USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer.J Exp Clin Cancer Res. 2019 Jun 14;38(1):259. doi: 10.1186/s13046-019-1262-4.
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Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p.J Biol Chem. 2018 May 4;293(18):6693-6706. doi: 10.1074/jbc.RA118.001689. Epub 2018 Mar 16.
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Intercellular transfer of P-glycoprotein mediates the formation of stable multi-drug resistance in human bladder cancer BIU-87 cells.Biol Open. 2019 May 1;8(5):bio041889. doi: 10.1242/bio.041889.
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Long non-coding RNA GHET1 contributes to chemotherapeutic resistance to Gemcitabine in bladder cancer.Cancer Chemother Pharmacol. 2019 Jul;84(1):187-194. doi: 10.1007/s00280-019-03873-8. Epub 2019 May 21.
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Long noncoding RNA FOXD2-AS1 accelerates the gemcitabine-resistance of bladder cancer by sponging miR-143.Biomed Pharmacother. 2018 Jul;103:415-420. doi: 10.1016/j.biopha.2018.03.138. Epub 2018 Apr 24.
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Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer.PLoS Pathog. 2014 Oct 30;10(10):e1004485. doi: 10.1371/journal.ppat.1004485. eCollection 2014 Oct.
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Autophagy induction enhances tetrandrine-induced apoptosis via the AMPK/mTOR pathway in human bladder cancer cells.Oncol Rep. 2017 Nov;38(5):3137-3143. doi: 10.3892/or.2017.5988. Epub 2017 Sep 21.
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Induction of Mitotic Catastrophe via Inhibition of Aurora B by Ionizing Radiation With Additive of Mulberry Water Extract in Human Bladder Cancer Cells.Integr Cancer Ther. 2019 Jan-Dec;18:1534735418808586. doi: 10.1177/1534735418808586. Epub 2018 Nov 15.
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