Details of the Drug Combination

General Information of Drug Combination (ID: DCD0K4Q)

Drug Combination Name
Vemurafenib Dactinomycin
Indication
Disease Entry Status REF
Large cell lung carcinoma Investigative [1]
Component Drugs Vemurafenib   DM62UG5 Dactinomycin   DM2YGNW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: NCI-H460
Zero Interaction Potency (ZIP) Score: 29.89
Bliss Independence Score: 29.98
Loewe Additivity Score: 28.43
LHighest Single Agent (HSA) Score: 27.9

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Vemurafenib
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [2]
Vemurafenib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Serine/threonine-protein kinase B-raf (BRAF) TTWCGQT BRAF_HUMAN Modulator [7]
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Vemurafenib Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [8]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [9]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [9]
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Vemurafenib Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [10]
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Vemurafenib Interacts with 19 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Microphthalmia-associated transcription factor (MITF) OT6XJCZH MITF_HUMAN Affects Expression [5]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [11]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [12]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [13]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [12]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [6]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Decreases Expression [14]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [12]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Decreases Expression [15]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Increases Expression [5]
Melanoma-associated antigen 1 (MAGEA1) OTXAO193 MAGA1_HUMAN Decreases Expression [5]
Thyroxine 5-deiodinase (DIO3) OTNTITOT IOD3_HUMAN Decreases Expression [16]
Melanoma antigen recognized by T-cells 1 (MLANA) OT1N2S2K MAR1_HUMAN Increases Expression [5]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [13]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Affects Response To Substance [17]
Serine/threonine-protein kinase B-raf (BRAF) OT7S81XQ BRAF_HUMAN Increases Response To Substance [18]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Decreases Response To Substance [19]
GTPase NRas (NRAS) OTVQ1DG3 RASN_HUMAN Affects Response To Substance [17]
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⏷ Show the Full List of 19 DOT(s)
Indication(s) of Dactinomycin
Disease Entry ICD 11 Status REF
Adult kidney Wilms tumor N.A. Approved [3]
Advanced cancer 2A00-2F9Z Approved [3]
Beckwith-Wiedemann syndrome N.A. Approved [3]
Childhood kidney Wilms tumor N.A. Approved [3]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [3]
Hamartoma N.A. Approved [3]
Solid tumour/cancer 2A00-2F9Z Approved [4]
Wilms tumor N.A. Approved [3]
Dactinomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [23]
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Dactinomycin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [24]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [25]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [26]
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Dactinomycin Interacts with 85 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [27]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [28]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [20]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Increases Expression [20]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [20]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Increases Expression [20]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Increases Expression [20]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [20]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [20]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [20]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [20]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [20]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [20]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Increases Expression [20]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [20]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [20]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [20]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [20]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Increases Expression [20]
Endonuclease III-like protein 1 (NTHL1) OTPQXPT1 NTH_HUMAN Decreases Expression [20]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [20]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [20]
Kinesin-like protein KIF1A (KIF1A) OT3JVEGV KIF1A_HUMAN Increases Expression [20]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [20]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [20]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Increases Expression [20]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [20]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [20]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [20]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Increases Expression [20]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Increases Expression [20]
Mitochondria-eating protein (SPATA18) OTOEHTHU MIEAP_HUMAN Increases Expression [20]
Phospholipase ABHD3 (ABHD3) OTH8P977 ABHD3_HUMAN Increases Expression [20]
Homer protein homolog 3 (HOMER3) OTQ6D9X1 HOME3_HUMAN Increases Expression [20]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [20]
Stathmin-3 (STMN3) OT20F289 STMN3_HUMAN Increases Expression [20]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [20]
Fatty acid desaturase 3 (FADS3) OT9RVXGE FADS3_HUMAN Increases Expression [20]
Protein O-mannosyl-transferase 1 (POMT1) OTGQSHL5 POMT1_HUMAN Increases Expression [20]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [29]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Decreases Expression [30]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [31]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [32]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [33]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [34]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [33]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [35]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Response To Substance [36]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [37]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Increases Expression [33]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [38]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [39]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [37]
Proto-oncogene tyrosine-protein kinase ROS (ROS1) OTDSKUGE ROS1_HUMAN Increases Expression [33]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [40]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [41]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [42]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [43]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [44]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [45]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [34]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [33]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [33]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [33]
rRNA 2'-O-methyltransferase fibrillarin (FBL) OTRODIE5 FBRL_HUMAN Affects Localization [46]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Decreases Phosphorylation [47]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [48]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [33]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [33]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [49]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Expression [33]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Decreases Expression [33]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [50]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [51]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [52]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Decreases Expression [33]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [33]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Increases Degradation [53]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [33]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [43]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Expression [40]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [54]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [34]
Hyaluronidase-1 (HYAL1) OT2SJN0X HYAL1_HUMAN Increases ADR [55]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Decreases Response To Substance [56]
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⏷ Show the Full List of 85 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Breast adenocarcinoma DC6WQSH MDA-MB-468 Investigative [57]
Carcinoma DCJF6IN RXF 393 Investigative [57]
Carcinoma DC8D3U0 MCF7 Investigative [57]
Colon adenocarcinoma DC2W0GH COLO 205 Investigative [57]
Colon carcinoma DCOGS3X KM12 Investigative [57]
Invasive ductal carcinoma DCYYZEV T-47D Investigative [57]
Invasive ductal carcinoma DCI3XU9 BT-549 Investigative [57]
Invasive ductal carcinoma DCCQAKR HS 578T Investigative [57]
Adenocarcinoma DC06LVW DU-145 Investigative [1]
Adenocarcinoma DCTSATO OVCAR3 Investigative [1]
Adenocarcinoma DCPJ0XN A549 Investigative [1]
Adenocarcinoma DCJYKYD NCIH23 Investigative [1]
Adenocarcinoma DCU71LX SW-620 Investigative [1]
Adenocarcinoma DCZIV2U HT29 Investigative [1]
Adenocarcinoma DC1759N HCC-2998 Investigative [1]
Adenocarcinoma DC0JR1W HCT-15 Investigative [1]
Adenocarcinoma DCBVANE HCT116 Investigative [1]
Adult acute myeloid leukemia DC6PGIV HL-60(TB) Investigative [1]
Adult T acute lymphoblastic leukemia DCD2XPX MOLT-4 Investigative [1]
Amelanotic melanoma DC9N6KJ M14 Investigative [1]
Amelanotic melanoma DCRX5AE MDA-MB-435 Investigative [1]
Anaplastic large cell lymphoma DC418ZG SR Investigative [1]
Astrocytoma DCZEUS1 U251 Investigative [1]
Astrocytoma DCZYNAD SNB-19 Investigative [1]
Childhood T acute lymphoblastic leukemia DCH0Q6L CCRF-CEM Investigative [1]
Chronic myelogenous leukemia DCJ0OT5 K-562 Investigative [1]
Clear cell renal cell carcinoma DCEIRZE TK-10 Investigative [1]
Clear cell renal cell carcinoma DCGKDPT 786-0 Investigative [1]
Clear cell renal cell carcinoma DC4F423 A498 Investigative [1]
Clear cell renal cell carcinoma DCJUC4L CAKI-1 Investigative [1]
Cutaneous melanoma DCS9E15 SK-MEL-5 Investigative [1]
Cutaneous melanoma DCHBIXH SK-MEL-28 Investigative [1]
Glioblastoma DCF32YH SNB-75 Investigative [1]
Glioma DCDHD51 SF-539 Investigative [1]
Glioma DC8B8KR SF-268 Investigative [1]
Glioma DC1QIQU SF-295 Investigative [1]
High grade ovarian serous adenocarcinoma DCQBQHU OVCAR-5 Investigative [1]
High grade ovarian serous adenocarcinoma DCN2VFE OVCAR-8 Investigative [1]
High grade ovarian serous adenocarcinoma DC8KH3Z OVCAR-4 Investigative [1]
Lung adenocarcinoma DCMHSOQ MDA-MB-231 Investigative [1]
Lung adenocarcinoma DCY3LH0 EKVX Investigative [1]
Lung adenocarcinoma DCC8BIS HOP-62 Investigative [1]
Lung adenocarcinoma DCKBA62 NCI-H522 Investigative [1]
Malignant melanoma DC9XVRI UACC62 Investigative [1]
Malignant melanoma DCG6ZHM LOX IMVI Investigative [1]
Melanoma DCRGZD3 UACC-257 Investigative [1]
Melanoma DCCVCA4 SK-MEL-2 Investigative [1]
Melanoma DCCDFJ8 MALME-3M Investigative [1]
Minimally invasive lung adenocarcinoma DCHM46W NCI-H322M Investigative [1]
Mixed endometrioid and clear cell carcinoma DCVFE4B IGROV1 Investigative [1]
Non-small cell lung carcinoma DC15OQ6 HOP-92 Investigative [1]
Ovarian serous cystadenocarcinoma DCFUQ92 SK-OV-3 Investigative [1]
Papillary renal cell carcinoma DCOHQ47 ACHN Investigative [1]
Plasma cell myeloma DCQGRQW RPMI-8226 Investigative [1]
Pleural epithelioid mesothelioma DCE65UG NCI-H226 Investigative [1]
Prostate carcinoma DCY3WUG PC-3 Investigative [1]
Renal cell carcinoma DCRSXZV SN12C Investigative [1]
Renal cell carcinoma DCJ24KS UO-31 Investigative [1]
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⏷ Show the Full List of 58 DrugCom(s)

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