Details of the Drug Combination

General Information of Drug Combination (ID: DCVW2A9)

Drug Combination Name
Anastrozole Dactinomycin
Indication
Disease Entry Status REF
Clear cell renal cell carcinoma Investigative [1]
Component Drugs Anastrozole   DMNP60F Dactinomycin   DM2YGNW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: CAKI-1
Zero Interaction Potency (ZIP) Score: 6.19
Bliss Independence Score: 6.2
Loewe Additivity Score: 7.15
LHighest Single Agent (HSA) Score: 6.72

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Anastrozole
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [2]
Estrogen-receptor positive breast cancer N.A. Approved [3]
Obesity 5B81 Approved [3]
Anastrozole Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [6]
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Anastrozole Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7) DT2EGUN S38A7_HUMAN Substrate [7]
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Anastrozole Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [8]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [8]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [8]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [8]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [8]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [8]
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⏷ Show the Full List of 6 DME(s)
Anastrozole Interacts with 6 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Adenylate kinase isoenzyme 1 (AK1) OT614AR3 KAD1_HUMAN Increases ADR [9]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Decreases Expression [10]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Activity [11]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Decreases Activity [12]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Decreases Expression [13]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [14]
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⏷ Show the Full List of 6 DOT(s)
Indication(s) of Dactinomycin
Disease Entry ICD 11 Status REF
Adult kidney Wilms tumor N.A. Approved [4]
Advanced cancer 2A00-2F9Z Approved [4]
Beckwith-Wiedemann syndrome N.A. Approved [4]
Childhood kidney Wilms tumor N.A. Approved [4]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [4]
Hamartoma N.A. Approved [4]
Solid tumour/cancer 2A00-2F9Z Approved [5]
Wilms tumor N.A. Approved [4]
Dactinomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [18]
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Dactinomycin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [19]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [20]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [21]
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Dactinomycin Interacts with 85 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [22]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [23]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [15]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Increases Expression [15]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [15]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Increases Expression [15]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Increases Expression [15]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [15]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [15]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [15]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [15]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [15]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [15]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Increases Expression [15]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [15]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [15]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [15]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [15]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Increases Expression [15]
Endonuclease III-like protein 1 (NTHL1) OTPQXPT1 NTH_HUMAN Decreases Expression [15]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [15]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [15]
Kinesin-like protein KIF1A (KIF1A) OT3JVEGV KIF1A_HUMAN Increases Expression [15]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [15]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [15]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Increases Expression [15]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [15]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [15]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [15]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Increases Expression [15]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Increases Expression [15]
Mitochondria-eating protein (SPATA18) OTOEHTHU MIEAP_HUMAN Increases Expression [15]
Phospholipase ABHD3 (ABHD3) OTH8P977 ABHD3_HUMAN Increases Expression [15]
Homer protein homolog 3 (HOMER3) OTQ6D9X1 HOME3_HUMAN Increases Expression [15]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [15]
Stathmin-3 (STMN3) OT20F289 STMN3_HUMAN Increases Expression [15]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [15]
Fatty acid desaturase 3 (FADS3) OT9RVXGE FADS3_HUMAN Increases Expression [15]
Protein O-mannosyl-transferase 1 (POMT1) OTGQSHL5 POMT1_HUMAN Increases Expression [15]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [24]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Decreases Expression [25]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [26]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [27]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [28]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [29]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [28]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [30]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Response To Substance [31]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [32]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Increases Expression [28]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [33]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [34]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [32]
Proto-oncogene tyrosine-protein kinase ROS (ROS1) OTDSKUGE ROS1_HUMAN Increases Expression [28]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [35]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [36]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [37]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [38]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [39]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [40]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [29]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [28]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [28]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [28]
rRNA 2'-O-methyltransferase fibrillarin (FBL) OTRODIE5 FBRL_HUMAN Affects Localization [41]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Decreases Phosphorylation [42]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [43]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [28]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [28]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [44]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Expression [28]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Decreases Expression [28]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [45]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [46]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [47]
Son of sevenless homolog 1 (SOS1) OTTCWXC3 SOS1_HUMAN Decreases Expression [28]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [28]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Increases Degradation [48]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [28]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [38]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Expression [35]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [49]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [29]
Hyaluronidase-1 (HYAL1) OT2SJN0X HYAL1_HUMAN Increases ADR [9]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Decreases Response To Substance [50]
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⏷ Show the Full List of 85 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DCERD1A DU-145 Investigative [1]
Adenocarcinoma DCHT8KY OVCAR3 Investigative [1]
Adenocarcinoma DCI9SJR A549 Investigative [1]
Adenocarcinoma DCXX35R NCIH23 Investigative [1]
Adenocarcinoma DCBVQFF SW-620 Investigative [1]
Adenocarcinoma DC2R9YV HCT116 Investigative [1]
Adenocarcinoma DCZC27R HCT-15 Investigative [1]
Adenocarcinoma DC6RPBF HCC-2998 Investigative [1]
Adenocarcinoma DC2GX7U HT29 Investigative [1]
Adult acute myeloid leukemia DC8AVFE HL-60(TB) Investigative [1]
Adult T acute lymphoblastic leukemia DCNBZ89 MOLT-4 Investigative [1]
Amelanotic melanoma DCHW0LI MDA-MB-435 Investigative [1]
Amelanotic melanoma DCYVK0R M14 Investigative [1]
Anaplastic large cell lymphoma DC42IQJ SR Investigative [1]
Astrocytoma DCT2QVV U251 Investigative [1]
Astrocytoma DCYWZPX SNB-19 Investigative [1]
Childhood T acute lymphoblastic leukemia DCA5LL7 CCRF-CEM Investigative [1]
Chronic myelogenous leukemia DCB8GD1 K-562 Investigative [1]
Clear cell renal cell carcinoma DC0WT1V A498 Investigative [1]
Clear cell renal cell carcinoma DC87DRU TK-10 Investigative [1]
Clear cell renal cell carcinoma DCHPZX2 786-0 Investigative [1]
Cutaneous melanoma DCPAJ4F SK-MEL-5 Investigative [1]
Cutaneous melanoma DCJQ3WP SK-MEL-28 Investigative [1]
Glioma DCI6ZZ2 SF-539 Investigative [1]
Glioma DCH5Y4R SF-295 Investigative [1]
Glioma DCL7RX4 SF-268 Investigative [1]
High grade ovarian serous adenocarcinoma DCKHGX6 OVCAR-5 Investigative [1]
High grade ovarian serous adenocarcinoma DCAN74L OVCAR-4 Investigative [1]
High grade ovarian serous adenocarcinoma DC903VE OVCAR-8 Investigative [1]
Large cell lung carcinoma DC3TRJB NCI-H460 Investigative [1]
Lung adenocarcinoma DCZOFNI EKVX Investigative [1]
Lung adenocarcinoma DC5WR25 MDA-MB-231 Investigative [1]
Lung adenocarcinoma DC7M074 HOP-62 Investigative [1]
Lung adenocarcinoma DCCI0RM NCI-H522 Investigative [1]
Malignant melanoma DCYB742 LOX IMVI Investigative [1]
Malignant melanoma DCRQQY4 UACC62 Investigative [1]
Melanoma DCVSM5U SK-MEL-2 Investigative [1]
Melanoma DCB3PFH UACC-257 Investigative [1]
Melanoma DC748SE MALME-3M Investigative [1]
Mixed endometrioid and clear cell carcinoma DC31K8Z IGROV1 Investigative [1]
Non-small cell lung carcinoma DC7CJFL HOP-92 Investigative [1]
Ovarian serous cystadenocarcinoma DCYCAHR SK-OV-3 Investigative [1]
Papillary renal cell carcinoma DC723OM ACHN Investigative [1]
Plasma cell myeloma DC3OJL9 RPMI-8226 Investigative [1]
Prostate carcinoma DCLZCCG PC-3 Investigative [1]
Renal cell carcinoma DCA9OJ6 UO-31 Investigative [1]
Renal cell carcinoma DC7195S SN12C Investigative [1]
Breast adenocarcinoma DCJA5N1 MDA-MB-468 Investigative [51]
Carcinoma DCHI90F RXF 393 Investigative [51]
Carcinoma DCF7EU5 MCF7 Investigative [51]
Colon adenocarcinoma DCEFNPL COLO 205 Investigative [51]
Colon carcinoma DCZESJD KM12 Investigative [51]
Invasive ductal carcinoma DCKXSIF BT-549 Investigative [51]
Invasive ductal carcinoma DCZSLQP HS 578T Investigative [51]
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⏷ Show the Full List of 54 DrugCom(s)

References

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