Details of the Drug Combination

General Information of Drug Combination (ID: DCX2QXA)

• Drug Combination Name: Anastrozole + Plicamycin
• Indication: Cutaneous melanoma; Status: Investigative [1]
• Component Drugs:
  Anastrozole (DMNP60F): Small molecular drug
  Plicamycin (DM7C8YV): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: SK-MEL-28
  Zero Interaction Potency (ZIP) Score: 5.65
  Bliss Independence Score: 5.37
  Loewe Additivity Score: 5.4
  LHighest Single Agent (HSA) Score: 5.05

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Anastrozole

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[2]
Estrogen-receptor positive breast cancer	N.A.	Approved	[3]
Obesity	5B81	Approved	[3]

Anastrozole Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Aromatase (CYP19A1)	TTSZLWK	CP19A_HUMAN	Inhibitor	[7]

Anastrozole Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7)	DT2EGUN	S38A7_HUMAN	Substrate	[8]

Anastrozole Interacts with 6 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[9]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[9]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[9]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[9]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Metabolism	[9]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Metabolism	[9]

Anastrozole Interacts with 6 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Adenylate kinase isoenzyme 1 (AK1)	OT614AR3	KAD1_HUMAN	Increases ADR	[10]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Decreases Expression	[11]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Decreases Activity	[12]
NADPH--cytochrome P450 reductase (POR)	OTVIDOCH	NCPR_HUMAN	Decreases Activity	[13]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Decreases Expression	[14]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[15]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[4]
Testicular cancer	2C80	Approved	[4]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[5]
Lung cancer	2C25.0	Investigative	[6]
Ovarian cancer	2C73	Investigative	[6]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[17]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[18]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[19]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[19]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[19]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[20]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[20]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[21]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[16]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[22]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[23]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[24]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[16]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[25]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[22]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[26]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[27]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DCYE4A6	DU-145	Investigative	[1]
Adenocarcinoma	DCYXCKT	A549	Investigative	[1]
Adenocarcinoma	DCIYDZ7	HT29	Investigative	[1]
Adenocarcinoma	DCUXZEP	HCC-2998	Investigative	[1]
Adenocarcinoma	DC90XQF	SW-620	Investigative	[1]
Adult acute myeloid leukemia	DCYY65A	HL-60(TB)	Investigative	[1]
Adult T acute lymphoblastic leukemia	DCZ5850	MOLT-4	Investigative	[1]
Amelanotic melanoma	DCGG84H	M14	Investigative	[1]
Childhood T acute lymphoblastic leukemia	DCUUUNL	CCRF-CEM	Investigative	[1]
Chronic myelogenous leukemia	DCQSU79	K-562	Investigative	[1]
Clear cell renal cell carcinoma	DCH73NY	A498	Investigative	[1]
Clear cell renal cell carcinoma	DCROOSX	786-0	Investigative	[1]
Glioblastoma	DC85V8S	SNB-75	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCF7GQ8	OVCAR-8	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCVNK5E	OVCAR-5	Investigative	[1]
Large cell lung carcinoma	DCNNX8T	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DCLLGQC	HOP-62	Investigative	[1]
Lung adenocarcinoma	DC3PUDI	MDA-MB-231	Investigative	[1]
Lung adenocarcinoma	DCKOAP8	NCI-H522	Investigative	[1]
Malignant melanoma	DCGXC2H	LOX IMVI	Investigative	[1]
Melanoma	DCD8ZMI	MALME-3M	Investigative	[1]
Melanoma	DCD1H8M	SK-MEL-2	Investigative	[1]
Melanoma	DCM3WX3	UACC-257	Investigative	[1]
Mixed endometrioid and clear cell carcinoma	DCOI9KK	IGROV1	Investigative	[1]
Ovarian serous cystadenocarcinoma	DC0S7IC	SK-OV-3	Investigative	[1]
Plasma cell myeloma	DC3UO3N	RPMI-8226	Investigative	[1]
Prostate carcinoma	DCJNKPH	PC-3	Investigative	[1]
Renal cell carcinoma	DC0Q76N	UO-31	Investigative	[1]
Breast adenocarcinoma	DC0L9MR	MDA-MB-468	Investigative	[28]
Carcinoma	DC2PVBM	RXF 393	Investigative	[28]
Carcinoma	DC6HWDC	MCF7	Investigative	[28]
Colon adenocarcinoma	DC2OUMY	COLO 205	Investigative	[28]
Invasive ductal carcinoma	DCKXCM0	HS 578T	Investigative	[28]
Invasive ductal carcinoma	DCK29HU	BT-549	Investigative	[28]

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