Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9LRKB)

Drug Name
Nicotinamide-Adenine-Dinucleotide Drug Info
Synonyms
NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM); AC1NRCGS; [[(2R,3S,4R,5R)-5-(6-amino-7H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
Cross-matching ID
PubChem CID
5892
ChEBI ID
CHEBI:44215
CAS Number
CAS 53-84-9
TTD Drug ID
DM9LRKB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenosylhomocysteinase (AHCY) TTE2KUJ SAHH_HUMAN Inhibitor [1]
Alpha-glucosidase (GLA) TTHCF4J LYAG_HUMAN; GANAB_HUMAN; GANC_HUMAN Inhibitor [1]
Bacterial Dehydroquinate synthase (Bact aroB) TTPS7KA AROB_ECOLI Inhibitor [1]
Bacterial Fatty acid synthetase I (Bact inhA) TTVTX4N INHA_MYCTU Inhibitor [1]
Bacterial Flavohemoglobin (Bact hmp) TTNAW8S HMP_ECOLI Inhibitor [1]
Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE) TT8WCXO NADE_ECOLI Inhibitor [1]
Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD) TT1NFO3 NADD_ECOLI Inhibitor [1]
Biliverdin reductase A (BLVRA) TTJBPN3 BIEA_HUMAN Inhibitor [1]
Deoxyhypusine synthase (DHPS) TTBO2A9 DHYS_HUMAN Inhibitor [1]
Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2) TTJS7O4 ADH2_ENTHI Inhibitor [1]
Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) TTIWB6L DHB1_HUMAN Inhibitor [1]
Estradiol 17 beta-dehydrogenase 4 (HSD17B4) TTL1WGS DHB4_HUMAN Inhibitor [1]
Glutathione reductase (GR) TTEP6RV GSHR_HUMAN Inhibitor [1]
Haemophilus influenzae NadR protein (Hae-influ nadR) TTWUDYC NADR_HAEIN Inhibitor [1]
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [1]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) TTTB4UP IMDH2_HUMAN Inhibitor [1]
Intestinal maltase-glucoamylase (MGAM) TTXWASR MGA_HUMAN Inhibitor [1]
L-lactate dehydrogenase (LDH) TTAZHU0 LDHA_HUMAN; LDHB_HUMAN; LDHC_HUMAN Inhibitor [1]
Mitochondrial aldehyde dehydrogenase (ALDH2) TTFLN4T ALDH2_HUMAN Inhibitor [1]
Plasmodium Enoyl-ACP reductase (Malaria fabI) TTNX2CS Q965D5_PLAFA Inhibitor [1]
Pseudomonas Nicotinate-nucleotide adenylyltransferase (Pseudo nadD) TTKVNRF NADD_PSEAE Inhibitor [1]
Sorbitoldehydrogenase (SORD) TTLSRBZ DHSO_HUMAN Inhibitor [1]
Trypanosoma Dihydrolipoamide dehydrogenase (Trypano LPD) TTBKQL3 DLDH_TRYCR Inhibitor [1]
UDP-glucose 4-epimerase (GALE) TTGRHIB GALE_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
HMG-CoA reductase (HMGCR) DTT HMGCR 6.357 6.256 5.17 6.85
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
HMG-CoA reductase (HMGCR) DTT HMGCR 1.01E-05 0.65 1.53
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.