Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1AGXN)

Drug Name
Paromomycin Drug Info
Synonyms
Aminosidin; Catenulin; Humatin; Hydroxymycin sulfate; Paramomycin Sulfate; Paromomycin I; Paromomycin sulfate Rx346208; Aminosidine, sulfate; HATT & Paromomycin; Humatin (TN); Paromomycin (INN); Paromomycin (TN); Paromomycin (complex); PA1-PA2-PA3-PA4; Human .alpha.-1-antitrypsin & Paromomyin; PAROMOMYCIN I, AMMINOSIDIN, CATENULIN, CRESTOMYCIN, MONOMYCIN A, NEOMYCIN E; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside; (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol; O-2-Amino-2-deoxy-.alpha.-D-glucopyranosyl-(1->4)-O-[O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1->3)-.beta.D-ribofuranosyl(1->5)]-2-deoxy-D-streptamine
Indication
Disease Entry ICD 11 Status REF
Intestinal amebiasis 1A36 Approved [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
165580
ChEBI ID
CHEBI:7934
CAS Number
CAS 7542-37-2
TTD Drug ID
DM1AGXN
ACDINA Drug ID
D00510

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetracycline DMZA017 Bacterial infection 1A00-1C4Z Approved [4]
Framycetin DMF8DNE Acute liver failure DB91 Approved [5]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [6]
Amikacin DM5PDRB Bacterial infection 1A00-1C4Z Approved [7]
Clomocycline DM0ZRMQ Bacterial infection 1A00-1C4Z Approved [8]
Spectinomycin DM0MQ35 Bacterial infection 1A00-1C4Z Approved [9]
Lymecycline DMOMLHJ Bacterial infection 1A00-1C4Z Approved [10]
Rolitetracycline DMBR5Q7 Acne vulgaris ED80 Approved [11]
Meclocycline DMSFQ8I Bacterial infection 1A00-1C4Z Approved [12]
Minocycline DMVN5OH Bacterial infection 1A00-1C4Z Approved [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [2] , [3]

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 064171.
2 Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
3 30S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli. Antimicrob Agents Chemother. 2002 May;46(5):1546-9.
4 The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
5 Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
6 Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6.
7 Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
8 Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
9 Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
10 Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
11 Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.
12 Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.
13 Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66.