Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2D947)

• Drug Name: Phosphoenolpyruvate Drug Info
• Synonyms: phosphoenolpyruvate; Phosphoenolpyruvic acid; 138-08-9; 2-(phosphonooxy)prop-2-enoic acid; Phosphopyruvic acid; 2-Propenoic acid, 2-(phosphonooxy)-; PEP; UNII-545YL308OW; 2-Phosphonooxyprop-2-enoic acid; 2-Dihydroxyphosphinoyloxyacrylic acid; CHEBI:44897; DTBNBXWJWCWCIK-UHFFFAOYSA-N; 545YL308OW; P-enol-pyruvate; Barium silver 2-(phosphonatooxy)acrylate; 2-phosphonooxyprop-2-enoate; 2-(phosphonooxy)-2-propenoic acid; 923-14-8; P-enolpyruvate; 1nhx; EINECS 213-089-8; EINECS 205-312-2; AC1L1AIQ; Phospho(enol)pyruvic acid; bmse000107

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1005
  ChEBI ID: CHEBI:44897
  CAS Number: CAS 138-08-9
  TTD Drug ID: DM2D947
  INTEDE Drug ID: DR2123

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Phosphoglyceric Acid	DMX6GH5	Discovery agent	N.A.	Investigative	[2]
Ribose-5-Phosphate	DMRKO49	Discovery agent	N.A.	Investigative	[2]
Arabinose-5-Phosphate	DMAM619	Discovery agent	N.A.	Investigative	[2]
1-Deoxy-Ribofuranose-5'-Phosphate	DMH9WFD	Discovery agent	N.A.	Investigative	[2]
3-Fluoro-2-(Phosphonooxy)Propanoic Acid	DMTY92S	Discovery agent	N.A.	Investigative	[2]
Erythose-4-Phosphate	DMLT7FQ	Discovery agent	N.A.	Investigative	[2]
2-(Phosphonooxy)Butanoic Acid	DM4V2ZO	Discovery agent	N.A.	Investigative	[7]

Drug(s) Metabolized By Phosphoenolpyruvate carboxykinase (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
oxalacetic acid	DMPZSV1	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Selenium	DM25CGV	N. A.	N. A.	Approved	[9]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[11]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[12]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[17]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[9]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[26]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA)	TTVNA43	KDSA_ECOLI	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Phosphoenolpyruvate carboxykinase (PCK1)	DEPLH5Z	PCKGC_HUMAN	Substrate	[3]
Red cell/liver pyruvate kinase (PKLR)	DETH24K	KPYR_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Protein Interaction/Cellular Processes	[5]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Regulation of Drug Effects	[6]

References

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• [19] Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
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