Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2KEW6)

• Drug Name: 3R14S-OCHRATOXIN A Drug Info
• Synonyms: Ochratoxin A; OCHRATOXIN A; Antibiotic 9663; 303-47-9; Phenylalanine - ochratoxin A; NCI-C56586; C20H18ClNO6; CHEBI:7719; RWQKHEORZBHNRI-BMIGLBTASA-N; Ochratoxin A, aspergillus ochraceus; Ochratoxin A-BSA conjugate from Aspergillus ochraceus; N-(((3R)-5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl-L-alanine; (-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine; NSC 201422; UNII-1779SX6LUY; OTA; ochratoxin A

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2]

• Cross-matching ID:
  PubChem CID: 442530
  ChEBI ID: CHEBI:7719
  CAS Number: CAS 303-47-9
  TTD Drug ID: DM2KEW6
  VARIDT Drug ID: DR00229

Molecule-Related Drug Atlas

Drug(s) Transported By Organic anion transporter 1 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[6]
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[7]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[8]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[9]
Aciclovir	DMYLOVR	Virus infection	1A24-1D9Z	Approved	[9]
Ganciclovir	DM1MBYQ	Virus infection	1A24-1D9Z	Approved	[9]
Cefazolin	DMPDYFR	Bacterial infection	1A00-1C4Z	Approved	[10]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[11]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[12]
Fluorescein	DMQTFAO	Ocular disease	1F00.1Z	Approved	[13]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[14]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[8]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[9]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[15]
Pravastatin	DM6A0X7	Hypercholesterolaemia	5C80.0	Approved	[16]
L-tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[17]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Pitavastatin calcium	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[19]
Rosuvastatin	DMMIQ7G	Hypercholesterolaemia	5C80.0	Approved	[20]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[21]

Drug(s) Transported By Organic anion transporter 4 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[8]
L-glutamic acid	DM4PUDW	Schizophrenia	6A20	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[9]
Pravastatin	DM6A0X7	Hypercholesterolaemia	5C80.0	Approved	[24]
Tetracycline	DMZA017	Bacterial infection	1A00-1C4Z	Approved	[25]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[26]
Estrone sulfate	DMVBIZL	Menopausal and postmenopausal disorder	GA30	Approved	[27]
Levocetirizine	DMQYLGP	Allergy	4A80-4A85	Approved	[28]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[8]

Drug(s) Transported By ATP-binding cassette sub-family A member 8 (ABCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone sulfate	DMVBIZL	Menopausal and postmenopausal disorder	GA30	Approved	[3]
Sodium taurocholate	DM3GO0J	Type-2 diabetes	5A11	Phase 1/2	[3]
Aminohippuric acid	DMUN54G	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Solute carrier family 22 member 8 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorescein	DMQTFAO	Ocular disease	1F00.1Z	Approved	[2]
Probenecid	DMMFWOJ	Gout	FA25	Approved	[29]
Buproprion+zonisamide	DMZC4V0	Obesity	5B81	Phase 2	[30]
Aminohippuric acid	DMUN54G	Discovery agent	N.A.	Investigative	[2]
Glutarate	DMPUFDS	Discovery agent	N.A.	Investigative	[2]
Adipate	DM2XI09	Discovery agent	N.A.	Investigative	[2]
HEPTANOATE	DMGEO8N	Discovery agent	N.A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 22 member 8 (SLC22A8)	TTTQR47	S22A8_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
ATP-binding cassette sub-family A member 8 (ABCA8)	DT9NXMV	ABCA8_HUMAN	Substrate	[3]
Organic anion transporter 4 (SLC22A11)	DT06JWZ	S22AB_HUMAN	Substrate	[4]
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[5]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4672).
• [2] Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17;282(33):23841-53.
• [3] Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5.
• [4] Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75.
• [5] Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35.
• [6] The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002 Jan;30(1):13-9.
• [7] Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9.
• [8] Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8.
• [9] Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
• [10] Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7.
• [11] Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76.
• [12] Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2.
• [13] Apical expression or expression in a non polarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1. Cell Physiol Biochem. 2004;14(3):177-86.
• [14] Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 2004 Oct;19(5):369-74.
• [15] Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86.
• [16] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8.
• [17] Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites. Am J Physiol Cell Physiol. 2005 Nov;289(5):C1075-84.
• [18] Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs. J Neurochem. 2004 Aug;90(4):931-41.
• [19] Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11.
• [20] The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. J Pharmacol Exp Ther. 2007 Sep;322(3):1221-7.
• [21] Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat. Drug Metab Dispos. 2014 Jun;42(6):996-1007.
• [22] Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71.
• [23] The role of the intracellular glutamate gradient in driving organic anion transporter function.
• [24] Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans. Xenobiotica. 2007 Apr;37(4):416-26.
• [25] Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
• [26] Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9.
• [27] Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. J Pharm Pharmacol. 2006 Nov;58(11):1499-505.
• [28] Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. J Pharm Sci. 2017 Sep;106(9):2895-2898.
• [29] Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158.
• [30] Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.