Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM38MU1)

• Drug Name: CD3254 Drug Info
• Synonyms: CD 3254; CD-3254

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44566110
  CAS Number: CAS 196961-43-0
  TTD Drug ID: DM38MU1

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[5]
2-chloro-5-nitro-N-phenylbenzamide	DMUGQIV	Discovery agent	N.A.	Investigative	[6]
AGN-34	DM5ECDM	Discovery agent	N.A.	Investigative	[7]
LG100754	DMEK4FY	Discovery agent	N.A.	Investigative	[8]
(5BETA)-PREGNANE-3,20-DIONE	DMVQ6RN	Discovery agent	N.A.	Investigative	[6]
phytanic acid	DMSZ1RB	Discovery agent	N.A.	Investigative	[9]
UVI3003	DM95UI1	Discovery agent	N.A.	Investigative	[10]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[6]
methoprene acid	DM58A0W	Discovery agent	N.A.	Investigative	[11]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[12]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[13]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[16]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[13]
Fructose	DM43AN2	Vomiting	MD90	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[13]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[20]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[12]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[27]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[12]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[28]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[31]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor RXR-alpha (RXRA)	TT6PEUO	RXRA_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Gene/Protein Processing	[3]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Gene/Protein Processing	[3]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Gene/Protein Processing	[3]

References

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• [21] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [22] Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice. J Pharmacol Exp Ther. 2018 Mar;364(3):452-461. doi: 10.1124/jpet.117.243105. Epub 2018 Jan 9.
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• [25] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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• [27] Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
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