Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM682UV)

• Drug Name: PD-158771 Drug Info
• Synonyms: PD 158771; N-[4-[2-(4-phenylpiperazin-1-yl)ethyl]cyclohexyl]pyrimidin-2-amine; Trans-N-(4-(2-(4-Phenyl-1-piperazinyl)ethyl)cyclohexyl)-2-pyrimidinamine

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 3075615
  CAS Number: CAS 189152-50-9
  TTD Drug ID: DM682UV

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D3 receptor (D3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cariprazine	DMJYDVK	Bipolar disorder	6A60	Approved	[2]
Pramipexole	DMNMW9R	Parkinson disease	8A00.0	Approved	[3]
Ropinirole	DMA6S1D	Parkinson disease	8A00.0	Approved	[3]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[4]
P2B-001	DM9PVHX	Parkinson disease	8A00.0	Phase 3	[5]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[6]
ONC201	DMM5SCF	Endometrial cancer	2C76	Phase 2	[7]
TAK-906	DMBQD9H	Diabetic gastroparesis	DA41.00	Phase 2	[8]
GSK598809	DMGU05N	Drug abuse	6C4G.1Z	Phase 2	[9]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[9]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[10]
Haloperidol	DM96SE0	Delirium		Approved	[11]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[12]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[13]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[14]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[15]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[16]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[17]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[18]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[19]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[3]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[20]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[21]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[22]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[2]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[23]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[24]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[25]
Treximet	DMU54QB	Migraine	8A80	Approved	[9]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Antagonist	[1]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Antagonist	[1]
Dopamine D3 receptor (D3R)	TT4C8EA	DRD3_HUMAN	Antagonist	[1]

References

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• [17] [The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome]. Nervenarzt. 2007 Mar;78(3):264, 266-8, 270-1.
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• [20] Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204.
• [21] Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9.
• [22] 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
• [23] Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
• [24] Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).
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