Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9OEJT)

• Drug Name: 2'-deoxythymidine triphosphate Drug Info
• Synonyms: Thymidine-5'-triphosphate; dTTP; thymidine 5'-triphosphate; Deoxy-TTP; Deoxythymidine 5'-triphosphate; 2'-Deoxythymidine triphosphate; 5'-TTP; THYMIDINE-5'-TRIPHOSPHATE; thymidine 5'-(tetrahydrogen triphosphate); TTP (nucleotide); thymidine triphosphate; pppdT; TTP; UNII-QOP4K539MU; 5-Methyl-dUTP; dThd5'PPP; CHEBI:18077; EINECS 206-669-7; QOP4K539MU; CHEMBL363559; 2'-Deoxythymidine 5'-triphosphate; 18423-43-3; [hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate; DEOXYTHYMIDINE_TRIPHOSPHATE; Thymidine-5'-Triphosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2] , [3]

• Cross-matching ID:
  PubChem CID: 64968
  ChEBI ID: CHEBI:18077
  CAS Number: CAS 365-08-2
  TTD Drug ID: DM9OEJT

Molecule-Related Drug Atlas

Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[5]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[6]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[7]
Tenofovir	DM1IS6U	Human immunodeficiency virus infection	1C62	Approved	[5]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[8]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[9]
Delavirdine	DM3NF5G	Human immunodeficiency virus infection	1C62	Approved	[8]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[8]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[10]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[11]

Drug(s) Targeting Thymidine kinase 1 (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penciclovir	DMOUMDV	Human immunodeficiency virus infection	1C62	Approved	[4]
DEOXYCYTIDINE	DMYE5LJ	Acute myeloid leukaemia	2A60	Approved	[12]
TK-DLI	DM26I8H	Graft-versus-host disease	4B24	Preregistration	[13]
FV-100	DMZARP1	Varicella zoster virus infection	1E91	Phase 3	[14]
Radiosensitizer gene therapy	DMN1ZEU	Pancreatic cancer	2C10	Phase 3	[15]
RP101	DMNIYSZ	Infectious disease	1A00-CA43.1	Phase 2/3	[16]
HQK-1004	DM3WX0K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[17]
Rilapladib	DMB9861	Arteriosclerosis	BD40	Phase 1	[18]
Ad-OC-hsvTK/valacyclovir	DM9GLHO	Prostate cancer	2C82.0	Phase 1	[19]
Thymidine kinase-expressing adenovirus and ganciclovir suicide gene therapy	DMO8SGD	Solid tumour/cancer	2A00-2F9Z	Phase 1	[20]

Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Aciclovir	DMYLOVR	Virus infection	1A24-1D9Z	Approved	[8]
Ganciclovir	DM1MBYQ	Virus infection	1A24-1D9Z	Approved	[22]
Valaciclovir	DMHKS94	Virus infection	1A24-1D9Z	Approved	[23]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[8]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[24]
Penciclovir	DMOUMDV	Human immunodeficiency virus infection	1C62	Approved	[25]
Famciclovir	DMJHLSD	Virus infection	1A24-1D9Z	Approved	[26]
Valacyclovir Hydrochloride	DM5I1CE	Herpes simplex virus infection	1F00	Approved	[8]
Foscavir	DM9KJLZ	Cytomegalovirus retinitis	9B72.00	Approved	[24]

Drug(s) Targeting Mycobacterium Thymidine monophosphate kinase (MycB tmk)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[4]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[27]
Deoxythymidine	DMR90HY	Discovery agent	N.A.	Investigative	[4]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[4]
Thymidine-5'-Phosphate	DMKM6NQ	Discovery agent	N.A.	Investigative	[4]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate	DMM4VWD	Discovery agent	N.A.	Investigative	[16]
3'-Azido-3'-Deoxythymidine-5'-Monophosphate	DMU08MN	Discovery agent	N.A.	Investigative	[4]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate	DMWVCJ1	Discovery agent	N.A.	Investigative	[4]
CHLORODEOXYURIDINE	DMQT3WJ	Discovery agent	N.A.	Investigative	[28]
BROMODEOXYURIDINE	DM0D7LA	Discovery agent	N.A.	Investigative	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[2]
Human immunodeficiency virus Reverse transcriptase (HIV RT)	TT84ETX	POL_HV1B1	Inhibitor	[3]
Mycobacterium Thymidine monophosphate kinase (MycB tmk)	TT5B8AX	KTHY_MYCTU	Inhibitor	[4]
Thymidine kinase 1 (TK1)	TTP3QRF	KITH_HUMAN	Inhibitor	[4]

References

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• [22] Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81.
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• [28] Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85.