Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDO175)

• Drug Name: 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione Drug Info
• Synonyms: 1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)-; 108774-82-9; ACMC-20mbs9; CHEMBL381099; CTK0G2626; DTXSID90449388

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10946795
  CAS Number: CAS 108774-82-9
  TTD Drug ID: DMDO175

Molecule-Related Drug Atlas

Drug(s) Targeting Protein kinase C epsilon (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meprobamate	DMHM93Y	Anxiety disorder	6B00-6B0Z	Approved	[2]
Bryostatin-1	DM1ZOCK	Alzheimer disease	8A20	Phase 2	[3]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
CDE-6960	DMA0DKI	Inflammation	1A00-CA43.1	Terminated	[6]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[1]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PD-0183812	DMWYP86	Retinoblastoma	2D02.2	Terminated	[9]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[10]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[1]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[11]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[1]
aloisine A	DM5U1LN	Discovery agent	N.A.	Investigative	[12]
3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol	DMJZK40	Discovery agent	N.A.	Investigative	[10]
(2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime	DMGXRSZ	Discovery agent	N.A.	Investigative	[13]
(2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime	DMZ0V6G	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABT-263	DMNE56X	Myelofibrosis	2A20.2	Phase 3	[14]
Briciclib	DMK7BND	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[10]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[1]
7-hydroxycoumarin	DMTMNO7	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting Protein kinase C alpha (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[17]
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[18]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[19]
ISIS 3521	DMZFS69	N. A.	N. A.	Discontinued in Phase 2	[20]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[21]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[22]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[23]

Drug(s) Targeting Protein kinase C gamma (PRKCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[24]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[21]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[25]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[1]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[26]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[24]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[26]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[27]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[28]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[26]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[29]
Oxazolyl methylthiothiazole derivative 1	DMZM6FW	N. A.	N. A.	Patented	[30]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[31]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[32]

Drug(s) Targeting Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[33]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[34]
Gefitinib	DM15F0X	Solid tumour/cancer	2A00-2F9Z	Approved	[35]
Erlotinib	DMCMBHA	Non-small-cell lung cancer	2C25.Y	Approved	[36]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[24]
Dacomitinib	DMOH8VY	Non-small-cell lung cancer	2C25.Y	Approved	[37]
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[38]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[39]
Epidermal growth factor	DMVONE6	Vulnerary	ND56.Z	Approved	[37]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[40]

Drug(s) Targeting Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[26]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[24]
PHA848125	DMS2Q9G	Thymic cancer	2C27	Phase 2	[41]
TG02	DMZFIGQ	Anaplastic astrocytoma	2A00.0	Phase 1/2	[42]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[28]
FN-1501	DM7BMD6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[43]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[26]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[29]
SNS-032	DMEITAS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[44]
CYC065	DM9ODT6	Lymphoma	2A80-2A86	Phase 1	[14]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[45]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[46]
Regorafenib	DMHSY1I	Metastatic colorectal cancer	2B91	Approved	[47]
Sunitinib	DMCBJSR	Gastrointestinal cancer	2C11	Approved	[48]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[49]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[24]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[50]
Cabozantinib	DMIYDT4	Thyroid cancer	2D10	Approved	[51]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[52]
Lenvatinib	DMB1IU4	Thyroid cancer	2D10	Approved	[53]

Drug(s) Targeting Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[54]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[56]
Ribociclib succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[57]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[58]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[59]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[24]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[26]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[60]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[14]

Drug(s) Targeting Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[54]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[56]
Ribociclib succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[57]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[58]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[59]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[14]
GLR2007	DM7DWLY	Glioblastoma of brain	2A00.00	Phase 1/2	[61]
FCN-437	DMQ8VUW	Breast cancer	2C60-2C65	Phase 1/2	[62]
FN-1501	DM7BMD6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[43]

Drug(s) Targeting Angiopoietin 1 receptor (TEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AKB-9778	DMKNRYH	Diabetic macular edema	9B71.02	Phase 2	[63]
DCC-2036	DMJKFNU	Chronic myeloid leukaemia	2A20	Phase 1/2	[14]
Altiratinib	DMUJCBT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
CEP-11981	DMYDTJ6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[65]
ARRY-614	DMXD93K	Arthritis	FA20	Discontinued in Phase 1	[66]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[1]
PMID21561767C8h	DMABZH6	Discovery agent	N.A.	Investigative	[67]
(4-Phenoxy-phenyl)-quinazolin-4-yl-amine	DMFO8DR	Discovery agent	N.A.	Investigative	[68]

Drug(s) Targeting ERBB2 messenger RNA (HER2 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HKI-272	DM6QOVN	Breast cancer	2C60-2C65	Phase 3	[69]
BMS-690514	DMX302C	Chronic pain	MG30	Phase 2	[70]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[1]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[11]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[1]
PMID24915291C38	DMBXT9J	Discovery agent	N.A.	Investigative	[71]
Geldanamycin-estradiol hybrid	DMUSJ96	Discovery agent	N.A.	Investigative	[72]
CL-387785	DMLKFZC	Discovery agent	N.A.	Investigative	[73]
HDS-029	DMLRUVA	Discovery agent	N.A.	Investigative	[73]

Drug(s) Targeting G2/mitotic-specific cyclin B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[32]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[74]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[74]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[1]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[1]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[1]
AZAKENPAULLONE	DM61H07	Discovery agent	N.A.	Investigative	[75]
Thieno analogue of kenpaullone	DMIOTHG	Discovery agent	N.A.	Investigative	[75]
3,4-bis(indol-3-yl)maleimide derivative	DMEQ1HC	Discovery agent	N.A.	Investigative	[74]
4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine	DMDW3SX	Discovery agent	N.A.	Investigative	[76]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiopoietin 1 receptor (TEK)	TT9VGXW	TIE2_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 1 (CDK1)	TTH6V3D	CDK1_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 2 (CDK2)	TT7HF4W	CDK2_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 4 (CDK4)	TT0PG8F	CDK4_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 6 (CDK6)	TTO0FDJ	CDK6_HUMAN	Inhibitor	[1]
Epidermal growth factor receptor (EGFR)	TTGKNB4	EGFR_HUMAN	Inhibitor	[1]
ERBB2 messenger RNA (HER2 mRNA)	TTR5TV4	ERBB2_HUMAN	Inhibitor	[1]
G1/S-specific cyclin-D1 (CCND1)	TTFCJ7S	CCND1_HUMAN	Inhibitor	[1]
G1/S-specific cyclin-E1 (CCNE1)	TTCEJ4F	CCNE1_HUMAN	Inhibitor	[1]
G2/mitotic-specific cyclin B1 (CCNB1)	TT9P6OW	CCNB1_HUMAN	Inhibitor	[1]
Protein kinase C alpha (PRKCA)	TTFJ8Q1	KPCA_HUMAN	Inhibitor	[1]
Protein kinase C epsilon (PRKCE)	TTBZ7OD	KPCE_HUMAN	Inhibitor	[1]
Protein kinase C gamma (PRKCG)	TTRFOXJ	KPCG_HUMAN	Inhibitor	[1]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]

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