Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHOG7W)

• Drug Name: SAG Drug Info
• Synonyms: 1-stearoyl-2-arachidonoyl-sn-glycerol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5284330
  ChEBI ID: CHEBI:138438
  CAS Number: CAS 364590-63-6
  TTD Drug ID: DMHOG7W

Molecule-Related Drug Atlas

Drug(s) Targeting Short transient receptor potential channel 2 (TRPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[2]
OAG	DMOP8IJ	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Short transient receptor potential channel 6 (TRPC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[5]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[5]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[5]
OAG	DMOP8IJ	Discovery agent	N.A.	Investigative	[3]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[5]
flufenamate	DMN8AP0	Discovery agent	N.A.	Investigative	[5]
ML9	DMP13VE	Discovery agent	N.A.	Investigative	[5]
hyp 9	DM0U8IV	Discovery agent	N.A.	Investigative	[6]
SLG	DMEBPCO	Discovery agent	N.A.	Investigative	[3]
20-HETE	DM5BAJ9	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By Zinc finger protein GLI1 (GLI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[9]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[14]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[15]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[16]

Drug(s) Affected By Paired box protein Pax-6 (PAX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[19]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[18]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[20]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[18]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[18]

Drug(s) Affected By Isocitrate dehydrogenase , mitochondrial (IDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[31]

Drug(s) Affected By Sonic hedgehog protein (SHH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[35]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Short transient receptor potential channel 2 (TRPC2)	TTSJ9E7	Q3C1U7_HUMAN	Activator	[2]
Short transient receptor potential channel 6 (TRPC6)	TTRBT3W	TRPC6_HUMAN	Activator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Isocitrate dehydrogenase , mitochondrial (IDH2)	OTTQA4PB	IDHP_HUMAN	Gene/Protein Processing	[4]
Paired box protein Pax-6 (PAX6)	OTOC9876	PAX6_HUMAN	Gene/Protein Processing	[4]
Sonic hedgehog protein (SHH)	OTOG2BXF	SHH_HUMAN	Gene/Protein Processing	[4]
Zinc finger protein GLI1 (GLI1)	OT1BTAJO	GLI1_HUMAN	Gene/Protein Processing	[4]

References

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