Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK209P)

• Drug Name: 1-(2-isopropylphenoxy)-3-morpholinopropan-2-ol Drug Info
• Synonyms: CHEMBL1083668; 1-(2-isopropylphenoxy)-3-morpholinopropan-2-ol; Oprea1_740178; AC1N31P0; 1-morpholin-4-yl-3-(2-propan-2-ylphenoxy)propan-2-ol; BDBM50318979

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4080436
  TTD Drug ID: DMK209P

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[2]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[3]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[4]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[5]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[5]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[5]
Timolol	DM3NXRU	High blood pressure	BA00	Approved	[6]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[7]
Betaxolol	DM6EUL5	Hypertension	BA00-BA04	Approved	[8]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[9]

Drug(s) Targeting Adrenergic receptor beta-3 (ADRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mirabegron	DMS1GYT	Overactive bladder	GC50.0	Approved	[10]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[11]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[12]
Bopindolol	DMIFYLX	Hypertension	BA00-BA04	Approved	[13]
Mepindolol	DMUDWP9	Angina pectoris	BA40	Approved	[14]
Rimiterol	DMA47C6	Asthma	CA23	Approved	[15]
Bitolterol	DMK6XAV	Chronic obstructive pulmonary disease	CA22	Approved	[16]
Nipradilol	DMA65ER	Angina pectoris	BA40	Approved	[17]
Vibegron	DMFR201	Overactive bladder	GC50.0	Approved	[18]
ONO-2506	DMCA2PJ	Stroke	8B20	Phase 2/3	[19]

Drug(s) Targeting Adrenergic receptor beta-2 (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indacaterol	DMQJHR7	Chronic obstructive pulmonary disease	CA22	Approved	[20]
Formoterol	DMSOURV	Allergic asthma	CA23.0	Approved	[21]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[22]
Arformoterol	DMYM974	Chronic obstructive pulmonary disease	CA22	Approved	[23]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[7]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[24]
Clenbuterol	DMCKYZ5	Chronic breathing disorder	7A4Z	Approved	[25]
Ritodrine	DM4V6RL	Premature labour	JB00	Approved	[26]
Olodaterol	DM62B78	Chronic obstructive pulmonary disease	CA22	Approved	[27]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Inhibitor	[1]
Adrenergic receptor beta-2 (ADRB2)	TT2CJVK	ADRB2_HUMAN	Inhibitor	[1]
Adrenergic receptor beta-3 (ADRB3)	TTMXGCW	ADRB3_HUMAN	Inhibitor	[1]

References

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• [17] Actions of nipradilol (K-351), a new alpha- and beta-adrenoceptor blocker, on the rabbit portal vein. Jpn J Pharmacol. 1984 Aug;35(4):359-69.
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• [19] FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus. Jpn J Pharmacol. 1997 May;74(1):109-12.
• [20] Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94.
• [21] Long-acting beta2-agonists for chronic obstructive pulmonary disease patients with poorly reversible airflow limitation. Cochrane Database Syst Rev. 2002;(3):CD001104.
• [22] Potential of beta2-adrenoceptor agonists as add-on therapy for multiple sclerosis: focus on salbutamol (albuterol). CNS Drugs. 2002;16(1):1-8.
• [23] Arformoterol tartrate in the treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease. Drugs Today (Barc). 2009 Jan;45(1):3-9.
• [24] Pharmacogenetic tests in asthma therapy. Clin Lab Med. 2008 Dec;28(4):645-65.
• [25] Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Anesth Analg. 2009 Jan;108(1):280-7.
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• [27] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [28] Functional alpha1- and beta2-adrenergic receptors in human osteoblasts. J Cell Physiol. 2009 Jul;220(1):267-75.