Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKAEQW)

• Drug Name: Phenyltoloxamine Drug Info
• Synonyms: Bristamin hydrochloride; Phenyltoloxamine hydrochloride; HL 2153; (2-(Dimethylamino)ethyl) (o-benzylphenoxy)ether hydrochloride; N,N-Dimethyl-2-(alpha-phenyl-o-toloxy)-ethylamine hydrochloride; ETHYLAMINE, 2-(o-BENZYLPHENOXY)-N,N-DIMETHYL-, HYDROCHLORIDE; Ethylamine, N,N-dimethyl-2-((alpha-phenyl-o-tolyl)oxy)-, hydrochloride; N-(2'-Dimethylaminoaethyl)-(o-benzylphenol)-aether hydrochlorid [German]; AC1L2KJQ; 92-12-6 (Parent); LS-67923; 2-(2-benzylphenoxy)ethyl-dimethylazanium chloride

Indication

Disease Entry	ICD 11	Status	REF
Allergy	4A80-4A85	Approved	[1]

• Cross-matching ID:
  PubChem CID: 7077
  ChEBI ID: CHEBI:135047
  CAS Number: CAS 92-12-6
  TTD Drug ID: DMKAEQW

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D1 receptor (D1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pergolide	DM14MAE	Parkinson disease	8A00.0	Approved	[3]
Methylergonovine	DMBEX4O	Spontaneous abortion	JA00.0	Approved	[4]
Fenoldopam	DMFAOKP	Hypertension	BA00-BA04	Approved	[5]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[6]
Ecopipam	DMS9R43	Cocaine addiction	6C45.2	Phase 3	[7]
DAS-431	DMM3BPL	Dementia	6D80-6D86	Phase 2	[8]
Dihydrexidine	DMACPQO	Psychotic disorder	6A20-6A25	Phase 1/2	[9]
Lu AF28996	DMY572G	Parkinson disease	8A00.0	Phase 1	[10]
BAM-1110	DMPMKUF	Parkinson disease	8A00.0	Discontinued in Phase 2	[11]
CY-208243	DMP8TKA	Pain	MG30-MG3Z	Discontinued in Phase 2	[12]

Drug(s) Targeting Dopamine D4 receptor (D4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[3]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[13]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[14]
L-745,870	DMTGR25	Psychotic disorder	6A20-6A25	Phase 2	[15]
NGD 94-1	DMM1Y8F	Schizophrenia	6A20	Phase 1	[16]
ABT-724	DMDQVY4	Erectile dysfunction	HA01.1	Discontinued in Phase 2	[17]
Lu-35138	DMQ7A35	Psychotic disorder	6A20-6A25	Discontinued in Phase 2	[18]
NGD-94-4	DMZ9WLO	Schizophrenia	6A20	Discontinued in Phase 1	[19]
PD-165167	DMD0GB4	Schizophrenia	6A20	Preclinical	[16]
SPI-376	DMC1WAJ	Schizophrenia	6A20	Preclinical	[16]

Drug(s) Targeting Dopamine D5 receptor (D5R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LE-300	DMGJL16	Schizophrenia	6A20	Preclinical	[16]
ZD-3638	DM6M9GC	Schizophrenia	6A20	Terminated	[16]
GMC-283	DMT1RH6	Schizophrenia	6A20	Terminated	[16]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[20]
ISOCLOZAPINE	DM52CPU	Discovery agent	N.A.	Investigative	[21]
FLUMEZAPINE	DMW0HOG	Discovery agent	N.A.	Investigative	[22]
ISOLOXAPINE	DMH1BN4	Discovery agent	N.A.	Investigative	[23]
1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine	DMOL2Y0	Discovery agent	N.A.	Investigative	[21]
1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine	DMD2NXL	Discovery agent	N.A.	Investigative	[2]
STEPHOLIDINE	DMGMXQC	Discovery agent	N.A.	Investigative	[24]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[25]
Haloperidol	DM96SE0	Delirium		Approved	[26]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[27]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[28]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[29]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[30]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[31]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[32]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[33]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[34]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D1 receptor (D1R)	TTZFYLI	DRD1_HUMAN	Inhibitor	[2]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Inhibitor	[2]
Dopamine D4 receptor (D4R)	TTE0A2F	DRD4_HUMAN	Inhibitor	[2]
Dopamine D5 receptor (D5R)	TTS2PH3	DRD5_HUMAN	Inhibitor	[2]

References

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