Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM75WZ)

• Drug Name: Chloroxylenol Drug Info
• Synonyms: Benzytol; Chloro-xylenol; Chloroxylenolum; Chlorxylenolum; Clorossilenolo; Cloroxilenol; Desson; Dettol; Dettol, liquid antiseptic; Espadol; Husept Extra; Nipacide MX; Ottasept; Ottasept Extra; Parametaxylenol; Phenol, 4-chloro-3,5-dimethyl-; RBA 777; Septiderm-Hydrochloride; Willenol V; chloroxylenol; p-Chloro-3,5-xylenol; p-Chloro-m-xylenol; parachlorometaxylenol; 2-Chloro-5-hydroxy-m-xylene; 2-Chloro-m-xylenol; 3,5-Dimethyl-4-chlorophenol; 4-Chloro-3,5-dimethylphenol; 4-Chloro-3,5-xylenol; 4-Chloro-m-xylenol; 88-04-0; PCMX
• Cross-matching ID:
  PubChem CID: 2723
  ChEBI ID: CHEBI:34393
  CAS Number: CAS 88-04-0
  TTD Drug ID: DMM75WZ
  INTEDE Drug ID: DR0302

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[3]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[5]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[1]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[6]
Metronidazole	DMTIVEN	Abscess		Approved	[7]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[8]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[10]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[11]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[5]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[14]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[15]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[16]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[17]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[18]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[22]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[23]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[1]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[24]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[26]

Drug(s) Affected By Sodium channel protein type 4 subunit alpha (SCN4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[32]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[1]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[1]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Sodium channel protein type 4 subunit alpha (SCN4A)	OT0MYDHC	SCN4A_HUMAN	Gene/Protein Processing	[2]

References

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