Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMK7XU)

• Drug Name: [3H]kainate Drug Info
• Synonyms: (2S,3S,4S)-3-(Carboxylatomethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylate; (2S,3S,4S)-3-(carboxylatomethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylate; GTPL4231; (2S,3S,4S)-3-(Carboxylatomethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylate; GTPL4085; KAINATE

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2]

• Cross-matching ID:
  PubChem CID: 73755076
  ChEBI ID: CHEBI:156548
  TTD Drug ID: DMMK7XU

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor AMPA 1 (GRIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[11]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[12]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[13]
Farampator	DM76GRQ	Major depressive disorder	6A70.3	Discontinued in Phase 1	[14]
GYKI-52466	DM3YG5P	Alzheimer disease	8A20	Terminated	[15]
GYKI-53655	DMC0JN8	N. A.	N. A.	Terminated	[16]
Zonampanel	DM70HZD	N. A.	N. A.	Terminated	[13]
SORETOLIDE	DMTDLHG	Convulsion	8A68.Z	Terminated	[17]
DNQX	DMQXPA5	Discovery agent	N.A.	Investigative	[18]
RPR-118723	DMLDWCB	Discovery agent	N.A.	Investigative	[19]

Drug(s) Targeting Adenosine A3 receptor (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IB-MECA	DM9G5XD	Psoriasis vulgaris	EA90	Phase 3	[20]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[21]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[22]
CF102	DMP56WJ	Hepatocellular carcinoma	2C12.02	Phase 2	[23]
SCH-442416	DMQ2K1V	N. A.	N. A.	Phase 1	[24]
BEMESETRON	DMSPJX9	N. A.	N. A.	Discontinued in Phase 3	[3]
BAY 60-6583	DMTEJV1	Myocardial ischemia	BA6Z	Preclinical	[25]
CF602	DM0ULO2	Inflammation	1A00-CA43.1	Preclinical	[23]
CF502	DMQSJ20	Inflammation	1A00-CA43.1	Preclinical	[23]
Methylthioadenosine	DMC8J6F	Multiple sclerosis	8A40	Terminated	[26]

Drug(s) Targeting Glutamate receptor AMPA (GRIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[27]
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[28]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[29]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[30]
Enflurane	DM0YJSB	Anaesthesia	9A78.6	Approved	[31]
Isoflurane	DMY6T31	Anaesthesia	9A78.6	Approved	[32]
Bromazepam	DMY9TCW	Anxiety disorder	6B00-6B0Z	Approved	[33]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[34]
Dihydroergotoxine	DM5D6WZ	Alzheimer disease	8A20	Approved	[35]
Barbiturate	DMJIA6T	Anaesthesia	9A78.6	Approved	[36]

Drug(s) Targeting Glutamate receptor ionotropic kainate 2 (GRIK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SYM2081	DM30WDL	Discovery agent	N.A.	Investigative	[7]
dysiherbaine	DM0EBAF	Discovery agent	N.A.	Investigative	[7]
domoic acid	DMYPVO0	Discovery agent	N.A.	Investigative	[7]
2,4-epi-neodysiherbaine	DMZRY0Q	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting Glutamate receptor ionotropic kainate 3 (GluK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SYM2081	DM30WDL	Discovery agent	N.A.	Investigative	[8]
dysiherbaine	DM0EBAF	Discovery agent	N.A.	Investigative	[8]
UBP310	DMVQL3J	Discovery agent	N.A.	Investigative	[37]

Drug(s) Targeting Glutamate receptor ionotropic kainate 1 (GRIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[38]
LY293558	DM4N6EK	Pain	MG30-MG3Z	Phase 2	[39]
NS 1209	DM9EFH0	Epilepsy	8A60-8A68	Phase 2	[40]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[41]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[41]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[6]
SYM2081	DM30WDL	Discovery agent	N.A.	Investigative	[5]
DNQX	DMQXPA5	Discovery agent	N.A.	Investigative	[18]
dysiherbaine	DM0EBAF	Discovery agent	N.A.	Investigative	[5]
domoic acid	DMYPVO0	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Glutamate receptor ionotropic kainate 4 (GluK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SYM2081	DM30WDL	Discovery agent	N.A.	Investigative	[9]
dysiherbaine	DM0EBAF	Discovery agent	N.A.	Investigative	[9]
domoic acid	DMYPVO0	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Glutamate receptor ionotropic kainate 5 (GRIK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SYM2081	DM30WDL	Discovery agent	N.A.	Investigative	[10]
dysiherbaine	DM0EBAF	Discovery agent	N.A.	Investigative	[10]
domoic acid	DMYPVO0	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A3 receptor (ADORA3)	TTJFY5U	AA3R_HUMAN	Inhibitor	[3]
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Inhibitor	[4]
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Inhibitor	[4]
Glutamate receptor ionotropic kainate 1 (GRIK1)	TT0MYE2	GRIK1_HUMAN	Agonist	[5] , [6]
Glutamate receptor ionotropic kainate 2 (GRIK2)	TT0K5RG	GRIK2_HUMAN	Agonist	[7]
Glutamate receptor ionotropic kainate 3 (GluK3)	TTNP6O2	GRIK3_HUMAN	Agonist	[8]
Glutamate receptor ionotropic kainate 4 (GluK4)	TTQV6BO	GRIK4_HUMAN	Agonist	[9]
Glutamate receptor ionotropic kainate 5 (GRIK5)	TTO6LI7	GRIK5_HUMAN	Agonist	[10]

References

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