Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMOFKD)

• Drug Name: NU-6102 Drug Info
• Synonyms: nu6102; 444722-95-6; NU 6102; O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE; Cdk1/2 Inhibitor II, NU6102; 6-Cyclohexylmethoxy-2-(4& -sulfamoylanilino)purine; 4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}benzenesulfonamide; 4SP; 1h1s; 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]benzenesulfonamide; 4-{[6-(cyclohexylmethoxy)-7h-purin-2-yl]amino}benzenesulfonamide; 4-[[6-(cyclohexylmethoxy)-9h-purin-2-yl]amino]benzenesulfonamide; 4eor; 4eok; 2iw9; 2c6o; 2iw8; AC1L1IGA; SCHEMBL2170816; CHEMBL319467

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4566
  CAS Number: CAS 444722-95-6
  TTD Drug ID: DMMOFKD

Molecule-Related Drug Atlas

Drug(s) Targeting PDK-1 messenger RNA (PDK-1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one	DM27WDP	Discovery agent	N.A.	Investigative	[3]
BX-517	DMBQIEF	Discovery agent	N.A.	Investigative	[3]
ISIS 29475	DMEBQUN	Discovery agent	N.A.	Investigative	[4]
ISIS 29233	DMGV4O7	Discovery agent	N.A.	Investigative	[4]
ISIS 29471	DMG4RMZ	Discovery agent	N.A.	Investigative	[4]
ISIS 29470	DMPCK7Y	Discovery agent	N.A.	Investigative	[4]
ISIS 29477	DMKQMXV	Discovery agent	N.A.	Investigative	[4]
ISIS 29239	DMHQF1J	Discovery agent	N.A.	Investigative	[4]
SU-6689	DMDNA23	Discovery agent	N.A.	Investigative	[3]
ISIS 29257	DMUM2H1	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Checkpoint kinase-1 (CHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY2603618	DMCXRZF	Pancreatic cancer	2C10	Phase 2	[5]
UCN-01	DMUNJZB	Non-small-cell lung cancer	2C25.Y	Phase 2	[6]
SCH-900776	DM67EMK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
LY2606368	DM4XMF7	Ovarian cancer	2C73	Phase 2	[8]
LY2880070	DMADEHZ	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[9]
RG7741	DMK6P9J	Lymphoma	2A80-2A86	Phase 1	[10]
GDC-0425	DMDZ26X	Lymphoma	2A80-2A86	Phase 1	[11]
AZD7762	DM1FW0C	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
MK-8776	DMAS1RB	Hodgkin lymphoma	2B30	Phase 1	[13]
Diamidothiazole derivative 1	DM02V5Q	N. A.	N. A.	Patented	[14]

Drug(s) Targeting Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[15]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[16]
PHA848125	DMS2Q9G	Thymic cancer	2C27	Phase 2	[17]
TG02	DMZFIGQ	Anaplastic astrocytoma	2A00.0	Phase 1/2	[18]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[19]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[20]
FN-1501	DM7BMD6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[21]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[22]
SNS-032	DMEITAS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[23]

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[24]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[25]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[26]
Tideglusib	DME4LA1	Alzheimer disease	8A20	Phase 2	[27]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[28]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[29]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[30]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[31]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[32]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[33]

Drug(s) Targeting Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[34]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[35]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[36]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[37]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[38]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[39]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[16]
P276-00	DM9DJL2	Mantle cell lymphoma	2A85.5	Phase 2	[15]
P-276	DMMJUHD	Breast cancer	2C60-2C65	Phase 2	[40]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Checkpoint kinase-1 (CHK1)	TTTU902	CHK1_HUMAN	Inhibitor	[2]
Cyclin-dependent kinase 2 (CDK2)	TT7HF4W	CDK2_HUMAN	Inhibitor	[1]
Cyclin-dependent kinase 4 (CDK4)	TT0PG8F	CDK4_HUMAN	Inhibitor	[1]
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[2]
PDK-1 messenger RNA (PDK-1 mRNA)	TTYMGWX	PDPK1_HUMAN	Inhibitor	[2]

References

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