Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP5I47)

• Drug Name: Dimethylallyl Diphosphate Drug Info
• Synonyms: di-CH3-allyl-PPi; dimethylallyl-PP; prenyl diphosphate trianion; delta-Prenyl diphosphate; prenyl-diphosphate; delta2-isopentenyl-diphosphate; prenyl diphosphate(3-); prenyl pyrophosphate trianion; polycis-polyprenyl diphosphate; GTPL3049; CHEBI:83374; CHEBI:57623; CTK4H5497; CHEBI:58914; CBIDRCWHNCKSTO-UHFFFAOYSA-K; Dimethylallyl pyrophosphate trianion; an all-trans-polyprenyl diphosphate; 3-methylbut-2-en-1-yl diphosphate; all-cis-polyprenyl diphosphate(3-); poly-cis-polyprenyl diphosphate(3-); all-trans-polyprenyl diphospha

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 647
  ChEBI ID: CHEBI:16057
  CAS Number: CAS 358-72-5
  TTD Drug ID: DMP5I47

Molecule-Related Drug Atlas

Drug(s) Targeting Geranyltranstransferase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[5]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[6]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[5]
Alendronate	DMY2KX9	Bone Paget disease		Approved	[5]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[7]
Incadronate	DM3DSVJ	Hypercalcaemia	5B91.0	Approved	[8]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[9]
NERIDRONIC ACID	DMMPG5V	Bone disease	FC0Z	Approved	[10]
Zarnestra	DMF30HL	Acute myeloid leukaemia	2A60	Phase 3	[11]
GERANYLGERANYL DIPHOSPHATE	DMJZ0AM	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Mevalonate kinase (MVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[12]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[13]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[14]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[20]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[21]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[25]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[26]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[28]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[29]

Drug(s) Affected By Interleukin-12 receptor subunit beta-1 (IL12RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[32]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[34]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[37]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interleukin-12 receptor subunit beta-1 (IL12RB1)	OTM1IJO2	I12R1_HUMAN	Gene/Protein Processing	[3]
Mevalonate kinase (MVK)	OTHJCUKT	KIME_HUMAN	Gene/Protein Processing	[4]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Gene/Protein Processing	[3]

References

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